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| 1 | CD4 + T Cell Epitope Discovery and Rational Vaccine Design显示文摘 | Daniela Santoro Rosa Susan Pereira Ribeiro Edecio Cunha-Neto | 2010 | Archivum Immunologiae et Therapiae Experimentalis2010，，： | 1 |
| 2 | CD4 + T Cell Epitope Dis-covery and Rational Vaccine Design 显示文摘 | Daniela Santoro Rosa Susan Pereira Ribeiro Edecio Cunha-Neto | 2010 | Ar-chivum Immunologiae et Therapiae Experimen-talis2010，2，： | 1 |
| 3 | Myocardial gene and protein expression profiles after autoimmune injury in Chagas’ disease cardiomyopathy显示文摘 | Edecio Cunha-Neto Priscila C. Teixeira Simone G. Fonseca Angelina M. Bilate Jorge Kalil | 2010 | Autoimmunity Reviews2010，，3： | 1 |
| 4 | CHAGAS DISEASE CARDIOMYOPATHY: CURRENT CONCEPTS OF AN OLD DISEASE显示文摘 | Bilate Angelina M B Cunha-Neto Edecio | 2008 | Revista do Instituto de Medicina Tropical de S茫o Paulo2008，，2： | 1 |
| 5 | Cardiac Gene Expression Profiling Provides Evidence for Cytokinopathy as a Molecular Mechanism in Chagas’ Disease Cardiomyopathy显示文摘 | Edecio Cunha-Neto Victor J. Dzau Paul D. Allen Dimitri Stamatiou Luiz Benvenutti M. Lourdes Higuchi Natalia S. Koyama Joao S. Silva Jorge Kalil Choong-Chin Liew | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 6 | Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy显示文摘Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(T.cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of T.cruzi infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease. | Ludmila Rodrigues Pinto Ferreira Amanda Farage Frade Monique Andrade Baron Isabela Cunha Navarro Jorge Kalil Christophe Chevillard Edecio Cunha-Neto | 2014 | World Journal of Cardiology2014，6，8： | 1 |
| 7 | Pathogenesis of Chagas disease cardiomyopathy显示文摘Chagas disease, or American trypanosomiasis, is a parasitic infection caused by the flagellate protozoanTrypanosoma cruzi. Chagas disease is mainly affecting rural populations in Mexico and Central and South America. The World Health Organization estimates that 300 000 new cases of Chagas disease occur every year and approximately 20 000 deaths are attributable to Chagas. However, this organisation classified Chagas disease as a neglected tropical disease. The economic burden of this disease is significant. In many Latin American countries, the direct and indirect costs, including the cost of health care in dollars and loss of productivity, attributable to Chagas disease ranges from $40 million to in excess of $800 million per nation per annum. So, it remains a contemporary public health concern. In chronic phase, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy(CCC) due to the persistence presence of parasites in the heart tissue. Mechanisms underlying differential progression to CCC are still incompletely understood. In the last decades immunological proteomic genetic approaches lead to significant results which help to disperse the veil covering the knowledge of the pathogenic process. Here, we reported these significant progresses. | Priscila Camillo Teixeira Amanda Farrage Frade Luciana Gabriel Nogueira Jorge Kalil Christophe Chevillard Edecio Cunha-Neto | 2012 | World Journal of Clinical Infectious Diseases2012，2，3： | 0 |
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