|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | S.J. Kalil F. Maugeri M.I. Rodrigues | 2000 | Process Biochemistry2000，，6： | 3 |
| 3 | Pseudomelanosis duodeni associated with chronic renal failure显示文摘Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different drugs.We report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin index.Gastroduodenal endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the moment.In addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological study.Even though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined. | Marcia Henriques de Magalhes Costa Maria da Gloria Fernandes Pegado Cleber Vargas Maria Elizabeth C Castro Kalil Madi Tiago Nunes Cyrla Zaltman | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Response surface analysis and sinulation as tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 5 | Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis显示文摘 | Barton P Kalil AC Nadel S | 2004 | Pediatrics2004，113，11： | 1 |
| 6 | Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia显示文摘 | Berton D C Kalil A C Teixeira P J | 2014 | Cochrane Database Syst Rev2014，30，00： | 1 |
| 7 | Ischemic Preconditioning Protects the Pig Liver by Preserving the Mitochondrial Structure and Downregulating Caspase-3 Activity显示文摘 | Rafael Omar Giovanardi Ernani Luis Rhoden Carlos Thadeu Cerski Miriam Salvador Antonio Nocchi Kalil | 2009 | Investigative Surgery2009，，2： | 1 |
| 8 | Effects ofprolonged use of azithromycin in patients with cystic fibrosis : ameia-analysis 显示文摘 | FLORKSCU D F MURPHY P J KALIL A C | 2009 | Pulm Pharmacol Ther2009，22，6： | 1 |
| 9 | Presence of apolipoprotein E epsilon4 allele in cerebral palsy 显示文摘 | MeireUes Kalil Pessoa de Barr Rodrigues CJ de Barros TE Bevilacqua RG | 2000 | Pediatric Orthop2000，20，6： | 1 |
| 10 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 11 | Experimental model of gene transfection in healthy canine myocardium : perspectives of gene therapy for ischemic heart disease 显示文摘 | Kalil RA Teixeira LA Mastalir ET | 2002 | Arq Bras Cardiol2002，79，3： | 1 |
| 12 | Response surface analysis and simulation as a tool for bioproeess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Pro- gress Biochemistry2000，35，6： | 1 |
| 13 | Axon branching requires interactions be- tween dynamic microtubules and actin filaments 显示文摘 | Dent EW Kalil K | 2001 | J Neuro- sci2001，21，24： | 1 |
| 14 | Safety,pharmacokinetics and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis显示文摘 | Barton P Kalil AC Nadel S | 2004 | Pediatrics2004，113，11： | 1 |
| 15 | Randomized study of surgi-eal isolation of the pulmonary veins for correction of permanent at- rial fibrillation associated with mitral valve disease 显示文摘 | Albrecht A Kalil R A Schuch L | 2009 | J Thorac Cardiovasc Surg2009，138，2： | 1 |
| 16 | Rethinking the multiple roles of B cells in organ transplantation 显示文摘 | Coelho V Saitovitch D Kalil J | 2013 | Curt Opin Organ Transplant2013，18，1： | 1 |
| 17 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil J Maugeri F Rodrigues M I | 2000 | Process Biochem2000，35，： | 1 |
| 18 | Malignancy in pigmented villonodular synovitis显示文摘 | KALIL R K UNNI K K | 1998 | Skeletal Rsdial1998，27，39： | 1 |
| 19 | Rheumatic heart disease : mediation by com- plex immune events显示文摘 | Guilherme L Khler KF Kalil J | 2011 | Adv Clin Chem2011，53，： | 1 |
| 20 | Rheumatic heart disease: molecules involved in valve tissue inflammation leading to the autoimmune process and anti-s, pyogenes vaccine 显示文摘 | GUILHERME L KALIL J | 2013 | Front Immunol2013，4，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员