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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 预防性水化对造影剂肾病高风险患者肾功能的保护作用——前瞻、随机、对照、开放、平行、非劣效性3期临床试验显示文摘血管内的碘化造影剂有损害肾功能风险,特别是原来就有肾功能损伤的患者。60多年前人们已经发现造影剂能够诱发肾病或急性肾损伤,并且是住院患者急性肾损伤的第三大常见原因。造影剂肾病(contrast—induced nephropathy,CIN)的特征是:患者通常在接受静脉或动脉内碘化造影剂2~5d后出现肾功能下降。虽然CIN与住院患者的死亡率增加相关,但其通常可以自动痊愈,只有不到1%的病例发生临床相关后遗症。全球每年有超过7500万次血管内碘化剂造影,考虑到慢性肾脏病(CKD)患病率为8%~16%,每年估计有600~1200万例CKD患者可能面对血管内碘化剂造影的风险,需要接受预防治疗。 | 王建中 Nijssen EC Rennenberg RJ Nelemans PJ | 2017 | 中华肾病研究电子杂志2017，6，2： | 38 |
| 3 | Radiation resistance and stem-like cells in brain tumors显示文摘The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding | Hambardzumyan D Squartro M Holland EC | 2006 | 中国神经肿瘤杂志2006，4，4： | 34 |
| 4 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 5 | Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence显示文摘BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom severity.AIM To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with autism.METHODS Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and wellbeing.RESULTS Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom severity was associated with maternal parenting competency with these relationships amplified among mothers with higher familial SES and who lived in areas of greater neighbourhood advantage.Increased adaptive functioning was associated with better maternal wellbeing,particularly among mothers who lived in areas of greater neighbourhood advantage. Contrastingly, paternal parenting competence was generally not influenced by child adaptive functioning or symptom severity, although for those in higher familial SES brackets, children's symptom severity and maladaptive symptoms were negatively related to paternal sense of parenting efficacy. There was a trend towards moderate relationships between lower familial SES and greater depression, stress and anxiety among fathers, but no relationship with their child's ASD symptom severity or functioning.CONCLUSION SES differentially impacts wellbeing and sense of parenting competence and its relationship to the impact of child symptoms for mothers and fathers of preschoolers with autism. | Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen | 2019 | World Journal of Psychiatry2019，9，2： | 6 |
| 6 | 风力机塔架的静载和动载显示文摘 | Klav.,EC 陈孝耀 | 1989 | 风力发电1989，6，3： | 5 |
| 7 | 急性心肌梗死后心脏康复训练的趋势和预测因素显示文摘急性心肌梗死后进行心脏康复训练已被证实能显著降低发病率和死亡率。从历史上看,患者参与心脏康复训练的比例一直很低,尽管最近的努力提高了宣传力度与参与率,但目前关于心脏康复参与率的相关研究数据仍有限。该研究利用疾病控制与预防中心进行的行为风险因素监测系统研究数据,对急性心肌梗死后参与心脏康复的对象进行了一项基于人群的横断面分析。应用单因素Logistic回归分析评估2005-2015年未经调整的参与率。 | 叶超毅 叶鹏 Peters AE Keeley EC | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 8 | 共用阿片类和苯二氮类药物与药物过量之间的关系:一项回顾性分析显示文摘目标确定同时使用苯二氮类药物和阿片类药物的趋势,确定这些趋势对阿片类药物过量导致的住院和急诊就诊的影响,提出修改建议。参与者:在研究期间,18~64岁的私人投保人连续参加医疗和药房福利健康计划的病人,并且至少接受过一张阿片类药物的处方。干预:同时使用苯二氮类药物/阿片类药物,定义为每种药物处方所涵盖的时间段内至少有一天重叠。主要观察结局指标:使用苯二氮类药物的阿片类药物使用者的年度百分比;每年发生的急诊就诊和阿片类药物过量住院事件。结果:阿片类药物使用者中在2001年使用苯二氮卓类药物的有9%,2013年增加到17%(相对增加80%)。这种增加主要是间断性阿片类药物使用者的增加,而非长期的阿片类药物使用者。与未使用苯二氮卓类药物的阿片类药物使用者相比,同时使用这两种药物与急诊室留观或阿片类药物过量住院相关的风险增加(校正比值比2.14,95%置信区间2.05-2.24;P<0.001)。间断性阿片类药物使用者的急诊室或住院病人阿片类药物过量的校正比值比为1.42(1.33-1.51;P<0.001),长期阿片类药物使用者为1.81(1.67-1.96;P<0.001)。如果这种关联是因果关系,那么消除同时使用两种药物的情况可以减少阿片类药物使用和阿片类药物过量住院病人因急诊就诊的风险,估计有15%(95%置信区间14-16)。结论:从2001年到2013年,在美国大量私人保险病人样本中,苯二氮类药物和阿片类药物的并用显着增加,并且导致总体人群阿片类药物过量使用的风险。 | Sun EC Dixit A Humphreys K 李楠琦 | 2018 | 中国疼痛医学杂志2018，24，6： | 5 |
| 9 | 恶性肿瘤的尸检诊断显示文摘 | Buton,EC 蔡松良 | 1999 | 美国医学会杂志(中文版)1999，18，3： | 4 |
| 10 | 混流式水轮机蜗壳周围混凝土应力分析显示文摘应用有限元法对混流式水轮机蜗壳周围混凝土作了位移和应力分析。所有工况中最小主应力为压应力,在卒环附近应力集中较高。最大主应力说明计算断面中曲面为拉应力区,并扩展到绕水轮机对称水平面各剖面的大多数中心区域。位移植小于蜗壳上涸青软木层的厚度。 | Kalk.,EC 王占臣 | 1996 | 国外大电机1996，，4： | 3 |
| 11 | 减低剂量预处理的异基因造血干细胞移植治疗复发性侵袭性非霍奇金淋巴瘤患者获长期存活显示文摘 | Thomson KJ Morris EC Bloor A 景晶 来晓瑜 | 2009 | 中华移植杂志(电子版)2009，3，3： | 3 |
| 12 | A comparison of postoperative complications in open versus robotic cystectomy显示文摘 | Ng CK Kauffman EC Lee MM | 2010 | European Urology2010，，02： | 2 |
| 13 | Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction:a quantitative review of 23 randomised trials显示文摘 | Keeley EC Boura JA Grines CL | | The Lancet0，，： | 2 |
| 14 | Effect of diclofenac sodium on the arachidonic acid cascade显示文摘 | Ku EC Lee W Kothari HV | 1986 | Am J Med1986，80，： | 2 |
| 15 | 哥伦比亚亚诺斯盆地山麓库西亚纳油田石油地质特征显示文摘库西亚纳油田位于哥伦比亚波哥大东北150英里(240千米)的亚诺斯山麓带。该油田的轻质油、天然气和凝析油出现在不对称背斜下盘圈闭内平均钻深15000英尺(4575米)处,中新世-全新世东科迪勒拉山脉形变时间,长15英里(25千米)、宽3-4英里(5-6千米)。渐新世卡沃内拉群的海相泥岩提供了顶部与侧向盖层,其烃柱超过1500英尺(460米),生物标记物资料说明海相泥岩源为土仑-科尼阿克加切塔组。 | Cazi.,EC 刘英爽 | 1998 | 石油勘探开发情报1998，，4： | 2 |
| 16 | Non-mutagenicity of KBT-1585, a novel ester of ampicillin显示文摘 | Yamabe S Mccoy EC Rosenkranz HS | 1984 | Chemotherapia1984，3，： | 2 |
| 17 | The occurrence of DBP in Utah drinking water显示文摘 | Nieminski EC Chaudhuri S Lamoreaux T | 1993 | JAWWA1993，85，： | 2 |
| 18 | WONCA研究论文摘要汇编——“以病人为中心的医疗团队”工作环境及满意度调查显示文摘目的探讨初级保健医疗机构中'以病人为中心的医疗团队'的改革对工作满意度的影响。方法2009—2011年,研究者收集罗得岛州和科罗拉多州参加'以病人为中心的医疗团队'试验项目的 20个初级保健机构的原始数据,就工作环境的质量(如:诊室噪声、交流、提供安全和优质服务的困难)及满意度进行从基线至30个月时的调查,同时就压力、倦怠、30个月时离开的意向进行调查;就试验项目的影响与机构领导进行访谈;评估工作环境及满意度的纵向变化,在项目的最后一年,检查工作环境与工作满意度、压力、倦怠、离开意向之间的横断面联系。结果从基线至30个月时,罗德岛州工作满意度有所改善(P=0.03),科罗拉多州未见明显改善。两个试点项目所报告的提供安全、高质量服务的困难有所减少(P<0.001),但诊室噪声水平及质量并无明显改善。横断面分析表明,更少的提供安全和优质服务的困难、优质服务和更加开放的沟通与工作满意度提高相关。更大的诊室噪声及加强电子信息与压力及倦怠增加相关。结论 '以病人为中心的医疗团队'的改革强调质量和开放式沟通,最大限度地降低诊室噪声有助于改善工作满意度。 | Alidina S Rosenthal MB Schneider EC 本刊编辑部 | 2014 | 中国全科医学2014，17，35： | 2 |
| 19 | Local drug and gene delivery through microbubbles 显示文摘 | Unger EC Hersh E Vannan M | 2001 | Prog Cardiovasc Dis2001，44，1： | 2 |
| 20 | 下湄公河流域国际组织机构及相应法律文件研究显示文摘本文回顾了下湄公河流域合作开发与管理的有关国际组织机构变化,分析了《下湄公河流域持续发展合作协定》诞生及新湄委会成立的背景;对比了该流域有关水资源及相关资源开发利用和管理的法律法规条款变化。 | 何大明 Chap.,EC | 1995 | 云南地理环境研究1995，7，1： | 2 |
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