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| 1 | 预期寿命估计对脊柱转移瘤手术选择与预后预测的临床意义显示文摘背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤患者手术选择与预后预测的临床价值。方法:对2001年1月至2004年4月丹麦奥胡斯大学医院脊柱外科中心收治的169例硬膜外脊柱转移瘤入组患者,术前用Tokuhashi与Tomita评分系统进行评分以及估计预期寿命,并结合Tomita脊柱肿瘤分型,选择实施手术分级治疗。术后6个月、12个月以及24个月分别进行前瞻性随访观察。对在预期寿命为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的患者通过Tokuhashi与Tomita评分系统绘制受试者作业特征曲线(receiveroperatingcharacteristiccurves,ROC曲线),比较两个评分系统对预期寿命估计的准确性。同时采用Kaplan-Meier生存曲线分析法,计算Tokuhashi和Tomita评分系统各分数段患者术后的实际平均生存时间。结果:预期寿命分别为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的病例ROC曲线分析显示,Tomita评分系统与Tokuhashi评分系统之间的差异均无显著性(各组P值分别为0.16、0.47与0.38)。Kaplan-Meier生存曲线分析显示,Tomita评分系统在4~7分之间对预后估计过高,Tokuhashi评分系统在0~8分之间对预后估计过低。结论:Tokuhashi和Tomita评分系统均可成功地预测脊柱转移瘤患者术后预后的情况。Tokuhashi评分系统可较为准确地预测生存期较短的患者,从而避免对这类患者做不必要的大手术。 | 邹学农 Anders Grejs 李海声 Kristian Hφy Ebbe S Hansen Cody Bünger | 2006 | 癌症2006，25，11： | 18 |
| 2 | Phytoextration of cadmium and zinc from a contaminated soil显示文摘 | Ebbs S D Lasat M M Brady D J | 1997 | Journal of Environmental Quality1997，26，5： | 1 |
| 3 | Intestinal absorption of protein hydrolysis products: A Review J 显示文摘 | Ebb K E | 1990 | Amin Sci1990，68，： | 1 |
| 4 | A novel diagnostic test for prostate cancer emerges from the determination of alpha-methylacylcoenzyme a racemase in prostatic secretions显示文摘 | Zielie PJ Mobey JA Ebb RG | 2004 | J Urol2004，172，3： | 1 |
| 5 | Phytoextraction of cadmium and zinc from a contaminated soil 显示文摘 | Ebbs S D Lasat M M Brady D J | 1997 | J Environ Quality1997，26，5： | 1 |
| 6 | Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrnzole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial显示文摘 | Smith IE Dowsett M Ebbs SR | 2005 | J Clin Oncol2005，23，22： | 1 |
| 7 | Requirement of the NF-kap- paB subunit p65/RelA for K-Ras-indueed lung tumorigenesis 显示文摘 | Bass:res DS Ebbs A Levantini E | 2010 | Cancer Res2010，70，9： | 1 |
| 8 | Green Process Development of Voficonazole : A Novel Broad - Spectrum Triazole Antifungal Agent 显示文摘 | Mike Butters Julie Ebbs Stuart P | 2001 | Organic Process Research & Development2001，5，1： | 1 |
| 9 | Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastroz, ole, Tamoxifen, or Combined with Tamoxifen (IMPACT)multicenter double-blind randomized trial 显示文摘 | Smith IE Dowsett M Ebbs SR | 2005 | J Clin Oncol2005，23，22： | 1 |
| 10 | The role of anterior surgery for vertebralfractures with and with out cord com pression显示文摘 | Hamilton A W ebb JK | 1994 | C in Orthp RelateResearch1994，300，25： | 1 |
| 11 | Toxicity of zinc to Brassica species: implication for phytoremediation 显示文摘 | Ebbs S D Kochian L V | 1997 | Journal of Environmental Quality1997，26，： | 1 |
| 12 | Toxicity of zinc and copper to Brozsica species : implications for phytoremediation 显示文摘 | EBBS S D KOCHIANDEZ L V | 1997 | Journal of Environmental Quality1997，26，： | 1 |
| 13 | Strengths-based practice withfamily caregivers of the chronically ill: qualitative insights families in society 显示文摘 | Berg-Weger M Rubio DM q'ebb SS | 2001 | Fam Soc2001，82，3： | 1 |
| 14 | Long-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County显示文摘 | Karen V. Winther Tine Jess Ebbe Langholz Pia Munkholm Vibeke Binder | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
| 15 | The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens显示文摘 | PENCE S N LARSEN P B EBBS S D | 2000 | Proceedings of the National Academy of Science USA2000，97，： | 1 |
| 16 | A novel diagnostic test for prostate cancer emerges from the determination of alpha-methylacyl-coenzyme A racemase in prostatic secretions显示文摘 | Zielie PJ Mobley JA Ebb RG | 2004 | J Urol2004，172，3： | 1 |
| 17 | Cloud based infrastructure, the new business possibilities and barriers显示文摘 | Christian Kloch Ebbe B Petersen and Ole Brun Madsen | 2011 | Wireless Personal Communitions2011，58，1： | 1 |
| 18 | Biomarker changes during neoadjuvant anastrozole,tamoxifen,or the combination:influence of hormonal status and HER-2 in breast cancer-a study from the IMPACT trialists显示文摘 | Dowsett M Ebbs SR Dixon JM | 2005 | J Clin Oncol2005，23，11： | 1 |
| 19 | Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina显示文摘 | Tina Friis Mandana Haack-S?rensen Anders B. Mathiasen Rasmus S. Ripa Ulrik S. Kristoffersen Erik J?rgensen Louise Hansen Lene Bindslev Andreas Kj?r Birger Hesse Ebbe Dickmeiss Jens Kastrup | 2011 | Scandinavian Cardiovascular Journal2011，，3： | 1 |
| 20 | Long-term risk of cancer in ulcerative colitis: A population-based cohort study from Copenhagen County显示文摘 | Karen V. Winther Tine Jess Ebbe Langholz Pia Munkholm Vibeke Binder | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
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