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| 1 | 不同能量和营养浓度饲粮添加益生素对生长肥育猪生长性能、养分消化率、肉品质和血液指标的影响显示文摘本研究旨在测定添加益生素(枯草芽孢杆菌孢子和丁酸梭菌孢子混合物)以及不同能量和营养浓度对生长肥育猪生长性能、养分消化率和肉品质的影响。选择96头初始体重为(47.50±1.14)kg的生猪,试验期10周。 | Meng Q W Yan L Ao X(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 65 |
| 2 | Immunopathogenesis of inflammatory bowel disease显示文摘Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. | David Q Shih Stephan R Targan | 2008 | World Journal of Gastroenterology2008，14，3： | 44 |
| 3 | Immunopathology of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)results from a complex series of interactions between susceptibility genes,the environment,and the immune system.The host microbiome,as well as viruses and fungi,play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.New technologies have allowed researchers to be able to quantify the various components of the microbiome,which will allow for future developments in the etiology of IBD.Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells,innate lymphoid cells,cells of the innate(macrophages/monocytes,neutrophils,and dendritic cells)and adaptive(T-cells and B-cells)immune system,and their secreted mediators(cytokines and chemokines).Either a mucosal susceptibility or defect in sampling of gut luminal antigen,possibly through the process of autophagy,leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity.The antigen presenting cells then mediate the differentiation of na?ve T-cells into effector T helper(Th)cells,including Th1,Th2,and Th17,which alter gut homeostasis and lead to IBD.In this review,the effects of these components in the immunopathogenesis of IBD will be discussed. | Kori L Wallace Li-Bo Zheng Yoshitake Kanazawa David Q Shih | 2014 | World Journal of Gastroenterology2014，20，1： | 45 |
| 4 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 5 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘 | Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z | 2006 | 中国生物学文摘2006，20，8： | 30 |
| 6 | 高强钢筋对框架结构抗震破坏机制和性能控制的研究显示文摘本文针对钢筋混凝土框架结构,在柱中配置高强钢筋作为纵筋,以实现对结构抗震破坏机制和性能的控制,并利用其弹性恢复特性,减小结构震后的残余变形。论文采用弹塑性时程分析方法,通过普通配筋和高强配筋的两个3层框架结构的地震响应分析,研究了高强钢筋对框架结构抗震破坏机制和性能控制的效果,及其地震响应和震后残余变形。研究结果表明,采用高强钢筋配筋后,不仅提高了框架结构整体抗震承载力,而且完全避免了出现柱铰屈服机制,并且地震后结构具有很小的残余变形,结构的损伤仅发生于框架梁端,有利于震后的加固修复。 | 叶列平 Asad U Q 马千里 陆新征 | 2006 | 工程抗震与加固改造2006，28，1： | 27 |
| 7 | 非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞显示文摘【据Hepatology 2020年5月报道】题:非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞(作者Liu XL等)肝脏巨噬细胞可被多种因素如肠道菌群代谢物以及受损的肝细胞释放物等激活。在非酒精性脂肪性肝病(NAFLD)的发生发展中,巨噬细胞向促炎表型(M1)的极化是一个重要的病理生理过程。外泌体可传递多种生物学成分如microRNA、蛋白质以及脂质等,因此被作为细胞间通讯的重要媒介。在NAFLD的发生发展过程中,外泌体在肝细胞与巨噬细胞对话中的作用尚未明确。 | 刘晓琳 范建高 LIU XL PAN Q CAO HX | 2020 | 临床肝胆病杂志2020，36，10： | 28 |
| 8 | Cardiac remodeling and physical training post myocardial infarction显示文摘After myocardial infarction(MI), the heart undergoes extensive myocardial remodeling through the accumulation of fibrous tissue in both the infarcted and noninfarcted myocardium, which distorts tissue structure, increases tissue stiffness, and accounts for ventricular dysfunction. There is growing clinical consensus that exercise training may beneficially alter the course of post-MI myocardial remodeling and improve cardiac function. This review summarizes the present state of knowledge regarding the effect of post-MI exercise training on infarcted hearts. Due to the degree of difficulty to study a viable human heart at both protein and molecular levels, most of the detailed studies have been performed by using animal models. Although there are some negative reports indicating that post-MI exercise may further cause deterioration of the wounded hearts, a growing body of research from both human and animal experiments demonstrates that post-MI exercise may beneficially alter the course of wound healing and improve cardiac function. Furthermore, the improved function is likely due to exercise training-induced mitigation of reninangiotensin-aldosterone system, improved balance between matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, favorable myosin heavy chain isoform switch, diminished oxidative stress, enhanced antioxidant capacity, improved mitochondrial calcium handling, and boosted myocardial angiogenesis. Additionally, meta-analyses revealed that exercise-based cardiac rehabilitation has proven to be effective, and remains one of the least expensive therapies for both the prevention and treatment of cardiovascular disease, and prevents re-infarction. | Michael A Garza Emily A Wason John Q Zhang | 2015 | World Journal of Cardiology2015，7，2： | 28 |
| 9 | Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。 | AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi | 2006 | World Journal of Gastroenterology2006，12，28： | 22 |
| 10 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 11 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 12 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 13 | 越南农业生产概况显示文摘概述了越南的地理位置及气候条件,指出根据越南地形、土壤和气候条件,可将越南农业划分为红河平原、北部丘陵山区、中山部及中部沿海地区、西原地区、东南部、九龙江平原6个生态区,并介绍了越南农业结构以及玉米、水稻、木薯、红薯、甘蔗、花生、大豆、茶叶、咖啡、橡胶、胡椒、腰果、椰子等主要农作物的生产概况。 | 吕荣华 高国庆 李丹婷 TRAN V Q 刘开强 唐茂艳 唐其展 周行 刘忠 | 2011 | 南方农业学报2011，42，5： | 20 |
| 14 | 2001~2011年中国ST段抬高型心肌梗死(回顾性急性心肌梗死研究China PEACE):一项基于医院数据的回顾性研究显示文摘背景:尽管ST段抬高型心肌梗死十分危险,但是过去10年中国并没有国家级有代表性的研究来描述其临床特征、处理方案以及结局。 | Li J Li X Wang Q 李汭傧 | 2014 | 临床荟萃2014，29，11： | 20 |
| 15 | Malignant peritoneal mesothelioma显示文摘Malignant mesothelioma is a highly aggressive neoplasm.The incidence of malignant mesothelioma is increasing worldwide.Diffuse malignant peritoneal mesothelioma(DMPM) represents one-fourth of all mesotheliomas.Association of asbestos exposure with DMPM has been observed,especially in males.The great majority of patients present with abdominal pain and distension,caused by accumulation of tumors and ascitic ? uid.In the past,DMPM was considered a pre-terminal condition;therefore attracted little attention.Patients invariably died from their disease within a year.Recently,several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy.This remarkable improvement in survival has prompted new search into the medical science related to DMPM,a disease previously ignored as uninteresting.This review article focuses on the key advances in the epidemiology,diagnosis,staging,treatments and prognosis of DMPM that have occurred in the past decade. | Stine Munkholm-Larsen Christopher Q Cao Tristan D Yan | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 19 |
| 16 | The Zoulang Nanshan Caledonian Subduct ion Complex in the Northern Qilian Mountains and Its Dynamics显示文摘The front of the Zoulang Nanshan Caledonian volcanic island arc zone in the northern Qilian Mountains is a forearc accretionary terrane, composed of multiple accretionary volcanic island arcs, flysch accretionary wedges,high-pressure metamorphosed detachment zones and remnants of ophiolites. It resulted from the northeastward subduction of the Early Palaeozoic Qilan oceanic crust beneath the Alxa block. High-pressure metamorphism, which occurred during the subduction, progressed through three stages: the initial stage of medium T-high P,the main stage of temperature decrease and pressure increase, and the lag stage of pressure decrease and temperature increase. Finally the paper presents a retrotrench subduction dynamic model indicative of northward subduction of the central Qilian block and southward accretion of the Alxa block during the period of 450-500 Ma. | Xu Zhiqin, Xu Huifen, Zhang Jianxin, Li Haibing, Zhu Zhizhi, Qu Jingchuan,Institute of Geology, Chinese Academy of Geological Sciences, BeijingChen Daizhang, Chen Jinlu, China University of Geosciences, Beijingand Yang KaichunNo. 2 Q ilian Geological Party, Bureau of Geology and Mineral Resources of Q inghai Province, Q ilian County, Q inghai | 1994 | Acta Geologica Sinica(English Edition)1994，68，3： | 19 |
| 17 | 在允许缺货情况下的易变质产品供应商管理库存显示文摘本文首先通过解析推导给出了一个考虑一个供应商和多个不同的订货商,并且允许订货商缺货的易腐商品供应商管理库存VMI(VendorManagedInventory)模型;其次通过mathematica4.2软件计算,给出了算例及其最优解,并通过灵敏度分析讨论了单位缺货成本和变质率对库存决策的影响;最后给出了总结,说明了研究的意义。 | 余玉刚 熊燕 董雨 Huang George Q | 2005 | 运筹与管理2005，14，2： | 18 |
| 18 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 19 | Mechanisms underlying feed intolerance in the critically ill: Implications for treatment显示文摘Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to improve mortality in non-malnourished critically ill patients, early enteral feeding is considered best practice. However, enteral feeding is often limited by delayed gastric emptying. The best method to clinically identify delayed gastric emptying and feed intolerance is unclear. Gastric residual volume (GRV) measured at the bedside is widely used as a surrogate marker for gastric emptying, but the value of GRV measurement has recently been disputed. While the mechanisms underlying delayed gastric emptying require further investigation, recent research has given a better appreciation of the pathophysiology. A number of pharmacological strategies are available to improve the success of feeding. Recent data suggest a combination of intravenous metoclopramide and erythromycin to be the most successful treatment, but novel drug therapies should be explored. Simpler methods to access the duodenum and more distal small bowel for feed delivery are also under investigation. This review summarises current understanding of the factors responsible for, and mechanisms underlying feed intolerance in critical illness, together with the evidence for current practices. Areas requiring further research are also highlighted. | Adam Deane Marianne J Chapman Robert J Fraser Laura K Bryant Carly Burgstad Nam Q Nguyen | 2007 | World Journal of Gastroenterology2007，13，29： | 18 |
| 20 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
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