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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 3 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 4 | Response of the newborn ureteropelvic iunction complex to indneed and later reversed partial ureteral obstruction in the rabbit model显示文摘 | Cheng EY Maizels M Chou P | 1993 | J Urol1993，150，2： | 1 |
| 5 | Suppression of human melanoma cell growth and metastasis by the melanoma- associated antigen CD63 ( MFA91 ) 显示文摘 | Radford K J Mallesch J Her~ey P | 1995 | Int J Cancer1995，62，5： | 1 |
| 6 | Optimization of carotenoid production by Rhodotorula glutinis using statistical experimental design显示文摘 | Park P K Cho DH Kim EY | 2005 | World Journal of Microbiology & Biotechnology2005，21，： | 1 |
| 7 | Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease 显示文摘 | Akerud P Canals JM Snyder EY | 2001 | J Neurosci2001，21，20： | 1 |
| 8 | Usefulness of anti-infective lock solutions for catheter-related bloodstream infections显示文摘 | Kim EY Saunders P Yousefzadeh N | 2010 | Mt Si- nai J Med2010，77，5： | 1 |
| 9 | Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease显示文摘 | Akerud P Canals JM Snyder EY | 2001 | J Neurosci2001，21，20： | 1 |
| 10 | Neuroprotection through delivery of glial cell linedrived neurotrophic factor by neural stem cells in a mouse of Parkinson′s disease显示文摘 | Akerud P Canals JM Snyder EY | 2001 | Neurosci2001，21，： | 1 |
| 11 | Estimates of global terreslrial isoprene emissions using MEGAN ( model of emissions of gases and aerosols from nature) 显示文摘 | GUENTHER A KARl T HARI EY P | 2006 | Atmospheric Chemistry and Physics Discussions2006，6，： | 1 |
| 12 | Chemorheology of t her mal: An overview显示文摘 | all ey P J Mackay M E | 1996 | Poly mer Engineeri ng and Science1996，36，5： | 1 |
| 13 | Synthesis of gra-phene aerogel with high electrical conductivity 显示文摘 | Wors|ey M A Pauzauskie P J Olson T Y | 2010 | Journal of the American Chemical Society2010，132，14： | 1 |
| 14 | Neural stem cellsconstitutively secrete neurotrophic factors and promote extensivehost axonal growth after spinal cord injury显示文摘 | Lu P Jones LL Snyder EY Tuszynski MH | 2003 | Exp Neurol2003，181，2： | 1 |
| 15 | Neuroprotection by taurine in ethanol --induced apoptosis in the developing cerebellum显示文摘 | Taranukhin AG Taranukhina EY Saransaari P Podkletnova IM Pelto--Huikko M Oja SS | 2010 | J Biomed Sci2010，，： | 1 |
| 16 | Fractal-based description of urban form显示文摘 | BAT/q( M LONGI EY P A | 1987 | Environment and planning B: Planning and Design1987，14，12： | 1 |
| 17 | Decolorization of vegetable oils:Chlorophyll-a adsorption by acid-activated sepiolite显示文摘 | Eyüp Sabah | 2007 | Journal of Colloid and interface science2007，310，： | 1 |
| 18 | Evidence linking the 68 kD antigen identified in progressive sensorineural hearing loss patient sera with hsp70显示文摘 | BILLINGS P B KEITHI EY E M HARRIS J P | 1995 | Ann Otol Rhinol Laryngol1995，104，3： | 1 |
| 19 | Division of Giardia osolates from humans into two genetically dis- tinct assemblages by electrophoretie analysis of en- zymes encoded at 27 loci and comparison with Giardia muris显示文摘 | Mayrhofer G Andrews R H Ey P L | 1995 | Parasitology1995，111，1： | 1 |
| 20 | Automated diagnosis and staging of Fuchs’endothelial cell corneal dystrophy using deep learning显示文摘Background:To describe the diagnostic performance of a deep learning algorithm in discriminating early-stage Fuchs’endothelial corneal dystrophy(FECD)without clinically evident corneal edema from healthy and late-stage FECD eyes using high-definition optical coherence tomography(HD-OCT).Methods:In this observational case-control study,104 eyes(53 FECD eyes and 51 healthy controls)received HDOCT imaging(Envisu R2210,Bioptigen,Buffalo Grove,IL,USA)using a 6 mm radial scan pattern centered on the corneal vertex.FECD was clinically categorized into early(without corneal edema)and late-stage(with corneal edema).A total of 18,720 anterior segment optical coherence tomography(AS-OCT)images(9180 healthy;5400 early-stage FECD;4140 late-stage FECD)of 104 eyes(81 patients)were used to develop and validate a deep learning classification network to differentiate early-stage FECD eyes from healthy eyes and those with clinical edema.Using 5-fold cross-validation on the dataset containing 11,340 OCT images(63 eyes),the network was trained with 80%of these images(3420 healthy;3060 early-stage FECD;2700 late-stage FECD),then tested with 20%(720 healthy;720 early-stage FECD;720 late-stage FECD).Thereafter,a final model was trained with the entire dataset consisting the 11,340 images and validated with a remaining 7380 images of unseen AS-OCT scans of 41 eyes(5040 healthy;1620 early-stage FECD 720 late-stage FECD).Visualization of learned features was done,and area under curve(AUC),specificity,and sensitivity of the prediction outputs for healthy,early and late-stage FECD were computed.Results:The final model achieved an AUC of 0.997±0.005 with 91%sensitivity and 97%specificity in detecting early-FECD;an AUC of 0.974±0.005 with a specificity of 92%and a sensitivity up to 100%in detecting late-stage FECD;and an AUC of 0.998±0.001 with a specificity 98%and a sensitivity of 99%in discriminating healthy corneas from all FECD.Conclusion:Deep learning algorithm is an accurate autonomous novel diagnostic tool of FECD with very high sensitivity and specificity that can be used to grade FECD severity with high accuracy. | Taher Eleiwa Amr Elsawy EyüpÖzcan Mohamed Abou Shousha | 2020 | Eye and Vision2020，7，1： | 1 |
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