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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Protein kinase C alpha is required for endothelin-1-induced proliferation of human myometrial cells显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Reprod2002，66，： | 1 |
| 3 | Differential expression of proteins in response to the interaction between the pathogen Fusarium graminearum and its host, Hordeum vulgare 显示文摘 | GEDDES J EUDES F LAROCHE A | 2008 | Proteomics2008，8，： | 1 |
| 4 | Protein kinase C alpha is required for endothelin-l-induced proliferation of human myomet rial cells显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Repord2002，66，1： | 1 |
| 5 | A novel method to induce direct somatic embryos, secondary embryogeuesis and regeneration of fertile cereal plants显示文摘 | Eudes F Acbaryl S Larochel A | 2003 | Plant Cell Tiss Organ Cuh2003，73，： | 1 |
| 6 | Protein kinase C alpha is required for endothelin linduced proliferation of human myometrial cells显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Reprod2002，66，： | 1 |
| 7 | Differential expression of proteins in response to the interaction between the patho- gen Fusarium graminearum and its host, Hordeurn vulgare 显示文摘 | Geddes J Eudes F Laroche A | 2008 | Proteomics2008，8，54： | 1 |
| 8 | Protein kinase calpha is required for endothelin-1-induced proliferation of human myometrial cell显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Reprod2002，66，1： | 1 |
| 9 | Cell-penetrating peptides: Nanocarrier for macromolecule delivery in living cells 显示文摘 | CHUGH A EUDES F SHIM Y S | 2010 | IUBMB Life2010，62，3： | 1 |
| 10 | Differential expression of proteins in response to the interaction between the pathogen Fusarium graminearum and its host, Hordeum vulgare 显示文摘 | Geddes J Eudes F Laroeh A | 2008 | Proteomics2008，8，3： | 1 |
| 11 | Protein kinase C alpha is required for endothelin - 1 - induced proliferation of human myometrial cells 显示文摘 | Eude I Dallot E Ferre F | 2002 | Biol Reprod2002，66，1： | 1 |
| 12 | Surveying the nuclear caloric curve显示文摘 | Y.-G Ma A Siwek J Péter F Gulminelli R Dayras L Nalpas B Tamain E Vient G Auger Ch.O Bacri J Benlliure E Bisquer B Borderie R Bougault R Brou J.L Charvet A Chbihi J Colin D Cussol E De Filippo A Demeyer D Doré D Durand P Ecomard P Eudes E Gerlic D Gourio | 1997 | Physics Letters B1997，，1： | 1 |
| 13 | Ammonium nitrate improves direct somatic embryogenesis and biolistic transformation of Triticum aestivum 显示文摘 | GREER M S KOVALCHUK I EUDES F | 2009 | New Biotechnology2009，26，12： | 1 |
| 14 | Phenotypic and marker-assisted evaluation of spring and winter wheat germplasm for re- sistance to fusarium head blight 显示文摘 | Badea A Eudes F Graf R J | 2008 | Euphytica2008，164，： | 1 |
| 15 | Trichothecenes in cereal grains显示文摘 | Foroud N A Eudes F | 2009 | Mol Sci2009，，1： | 1 |
| 16 | Translocation and nuclear accumulation of monomer and dimer of HIV-1 Tat basic domain in triticale mesophyll protoplasts 显示文摘 | Chugh A Eudes F | 2007 | Biochim Biophys Acta2007，1768，3： | 1 |
| 17 | Protein kinase Calpha is required for endothelin-1-induced proliferation of human myometrial cells显示文摘 | Eude I Da llot E Ferre F | 2002 | B iol Reprod2002，66，1： | 1 |
| 18 | Identification of differentially regulated proteins in response to a compatible interaction between the pathogen Fusarium graminearum and its host, Triticum aestivum显示文摘 | ZHOU W EUDES F LAROCHE A | 2006 | Proteomics2006，6，16： | 1 |
| 19 | Identification of differentially regulated proteins in response to a compatible interaction between the pathogen Fusarium graminearum and its host,Triticum aestivum显示文摘 | ZHOU W EUDES F LAROCHE A | 2006 | Proteomics2006，6，： | 1 |
| 20 | Transient embryo-specific expression of anthocyanin in wheat显示文摘 | Doshi KM Eudes F Laroche A Gaudet D | | 0，，： | 1 |
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