|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chaperone-mediated autophagy: roles in disease and aging显示文摘这评论集中于调停女伴的 autophagy (CMA ) ,在 lysosomes 贡献细胞内部的蛋白质的降级的解朊的系统之一。CMA 底层蛋白质有选择地通过在膜和奉献蛋白质 translocation 建筑群的双方定位的女伴的协调行动被指向到 lysosomes 和 translocated 进 lysosomal 腔。CMA 许可证的选择与在细胞的 transcriptional 程序的酶的新陈代谢的进程和子集为 CMA 支持一个调节角色的规章的目的预定了特定的蛋白质的降级。另外, CMA 通过移动贡献细胞的质量控制损坏或失灵蛋白质。这里,我们在 CMA 的分子的动力学,规定和生理学的理解描述最近的进展,并且在对象 neurodegeneration 和癌症那样的严重人的混乱的 CMA 机能障碍的贡献的支持讨论证据。 | Ana Maria Cuervo Esther Wong | 2014 | Cell Research2014，24，1： | 57 |
| 2 | Physical exercise in the prevention and treatment of Alzheimer’s disease显示文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. | Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera | 2020 | Journal of Sport and Health Science2020，9，5： | 32 |
| 3 | 卫生经济学评价报告标准共识2022(CHEERS 2022):卫生经济学评价报告指导意见更新版显示文摘卫生经济学评价是对备选行动方案的成本和结果的比较分析。2013年发表的《卫生经济学评价报告标准共识》(CHEERS)提出了卫生经济学评价的特点,确保结果正确阐释,以支持决策制订。2013版CHEERS旨在指导研究报告撰写者准确报告卫生干预和对照措施、背景、过程、结果等评价细节,使审稿人理解文章内容,帮助读者使用研究结果。本版共识将取代2013版共识,其更加适用于各类卫生经济学评价,结合学科发展和方法更新的需要,更注重患者、公众等相关利益方的参与。本共识适用多种个体或人群健康干预措施(简单或复杂)在不同政策场景的应用分析,包括医疗服务、公共卫生、教育、社会服务等。本文概要介绍了CHEERS 2022共识中包含的28个检查项及每一个检查项的相关建议。CHEERS 2022共识主要用于指导研究人员撰写拟投递同行评议学术期刊的卫生经济学评价文章,亦可用于期刊编辑和审稿专家对待发表文章的评价。熟悉了解本共识要求,还有助于研究人员规划评价研究。随着决策透明度要求提高,本共识可支持卫生技术评估机构建立评价报告标准。 | Don Husereau Michael Drummond Federico Augustovski Esther de Bekker-Grob Andrew H Briggs Chris Carswell Lisa Caulley Nathorn Chaiyakunapruk Dan Greenberg Elizabeth Loder Josephine Mauskopf C Daniel Mullins Stavros Petrou Raoh-Fang Pwu Sophie Staniszewska on behalf of CHEERSISPOR Good Research Practices Task Force 肖月(译) 邱英鹏(译) 史黎炜(译) 张治国(译) 张歆(译) 王海银(译) 翟铁民(译) | 2022 | 英国医学杂志中文版2022，25，8： | 31 |
| 4 | 师生互动的实证研究:中芬法澳四国中学数学课堂中的师生互动显示文摘师生互动是中学数学课堂中的关键教学行为。通过选取中国、芬兰、法国和澳大利亚四个国家中学数学课堂录像进行实证研究,探寻出中芬法澳课堂中师生互动模式的可能形态:整体态势上中国课堂中的师生互动较为静态,并表现出教师主导性;而芬法澳三国的师生互动更为动态。互动模式1:教师提问-学生回答是各国主导的师生互动模式,中国尤甚;中国的互动模式1与芬法澳迥异,主要表现在互动对象上;互动模式2:学生提问-教师回答在中国课堂几乎缺失;互动模式3:教师讲解-学生听讲是各国课堂知识传输的主要媒介,中国课堂中尤甚;互动模式4:学生做题-教师辅导中的教师辅导,在中国主要表现为全班集中讲解,体现出集体主义色彩,在芬法澳课堂中主要是个性化、针对性的小组或个别辅导;互动模式5:课堂管理在芬法澳课堂是重要的师生互动形式,中国课堂缺失。 | 于国文 曹一鸣 David Clarke Man Ching Esther Chan | 2019 | 全球教育展望2019，48，1： | 27 |
| 5 | Current status of laparoscopic and robotic ventral mesh rectopexy for external and internal rectal prolapse显示文摘External and internal rectal prolapse with their affiliated rectocele and enterocele, are associated with debilitating symptoms such as obstructed defecation, pelvic pain and faecal incontinence. Since perineal procedures are associated with a higher recurrence rate, an abdominal approach is commonly preferred. Despite the description of greater than three hundred different procedures, thus far no clear superiority of one surgical technique has been demonstrated. Ventral mesh rectopexy(VMR) is a relatively new and promising technique to correct rectal prolapse. In contrast to the abdominal procedures of past decades, VMR avoids posterolateral rectal mobilisation and thereby minimizes the risk of postoperative constipation. Because of a perceived acceptable recurrence rate, good functional results and low mesh-related morbidity in the short to medium term, VMR has been popularized in the past decade. Laparoscopic or robotic-assisted VMR is now being progressively performed internationally and several articles and guidelines propose the procedure as the treatment of choice for rectal prolapse. In this article, an outline of the current status of laparoscopic and robotic ventral mesh rectopexy for the treatment of internal and external rectal prolapse is presented. | Jan J van Iersel Tim JC Paulides Paul M Verheijen John W Lumley Ivo AMJ Broeders Esther CJ Consten | 2016 | World Journal of Gastroenterology2016，22，21： | 20 |
| 6 | Phase Transformation under Continuous Cooling Conditions in Medium Carbon Microalloyed Steels显示文摘Several 35CrMo4 and 38MnV7 steels with different additions of Ti and V were manufactured by electroslag remelting.The influence of the alloying and microalloying elements on phase transformation at different cooling rates was studied and the continuous cooling transformation diagrams were plotted.In order to optimize the heat treatment and improve the mechanical properties,the range of cooling rates leading to a fully bainitic microstructure(without ferrite,pearlite and especially without martensite)was determined.Bainite and martensite transformation start temperatures(B_s,M_s)were also established and compared with the values predicted by empirical equations.The important role of precipitates(especially V carbonitride particles)on final microstructure and mechanical properties was assessed. | Manuel Gomez Lucia Rancel Esther Escudero Sebastian F.Medina | 2014 | Journal of Materials Science & Technology2014，30，5： | 16 |
| 7 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 8 | 利用颜色的非刚性物体跟踪方法(英文)显示文摘提出了一个利用颜色特征实时跟踪非刚性物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具鲁棒性 ,对放缩和旋转具不变性 ,且计算简单 .对非刚体物体的实时鲁棒跟踪是一个非常有挑战性的课题 ,本文提出了利用颜色特征实时跟踪非刚体物体的方法 .首先 ,建立了一个颜色分布模型 ,该模型对部分遮挡具有鲁棒性 ,对放缩具有不变性 ,而且计算简单 .然后 ,采用粒子滤波的方法将颜色分布模型集成到一个动态状态估计的概率框架中 .为了处理光照变化等引起的外貌变化 ,进一步引入自适应模型更新过程 .同时 。 | Katja Nummiaro Esther Koller-Meier Luc Van Gool | 2003 | 自动化学报2003，29，3： | 15 |
| 9 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 10 | Apoptosis in skeletal muscle and its relevance to atrophy显示文摘Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal system. The role of apoptosis in post mitotic tissues, such as skeletal muscle, is less well defined. Apoptosis during muscle atrophy occurs in both myonuclei and other muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as -independent pathways have been implicated and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss. | Esther E Dupont-Versteegden | 2006 | World Journal of Gastroenterology2006，12，46： | 12 |
| 11 | Systemic treatment of hepatocellular carcinoma:Past,present and future显示文摘Hepatocellular carcinoma(HCC) is a common neoplasia which represents the second leading cause of cancer related death. Most cases occur in developing countries, but its incidence is rising in Western countries due to hepatitis C. Although hepatitis therapies have evolved and the HCC screening has increased in several areas, 40% present with advanced disease which is only amenable for palliative systemic treatment. HCC continues posing a challenge, in part due to the inherent chemoresistance of this neoplasia, the pharmacologic challenges due to an ill liver, difficulty in assessing radiological responses accurately, etc. Traditional chemotherapy have shown some responses without clear survival benefit, however, sorafenib demonstrated advantages in survival in advanced HCC when liver function is kept and recently immunotherapy seems to be a promising approach for some patients. This article will briefly expose the most relevant systemic treatment modalities to offer a general view from the past to the future. | Esther Una Cidon | 2017 | World Journal of Hepatology2017，9，18： | 11 |
| 12 | Prospects for ASEAN-China Free Trade Area:A Qualitative and Quantitative Analysis显示文摘当前的全球金融、经济的危机把新生命正在给在东方亚洲国家之中支持更近经济的集成的行动。一个重要例子是 ASEAN 中国自由贸易区域(ACFTA ) ,它被设置在 2010 附近实行。ACFTA 试图增加在是象竞争者一样的搭挡的二经济之间的贸易:ASEAN 和中国。在现在的论文,我们在 ACFTA 是否将有益于双方的质的分析从习俗联合理论使用卓见。我们也使用一个可计算出来的一般平衡模型执行一样的问题的定量分析。两我们的质、量的分析为加强在 ASEAN 和中国之间的经济合伙作为车辆关于 ACFTA 的前景为看守乐观主义提供根据。 | Donghyun Park Innwon Park Gemma Esther B.Estrada | 2009 | China & World Economy2009，17，4： | 11 |
| 13 | From leaf to whole-plant water use efficiency(WUE)in complex canopies:Limitations of leaf WUE as a selection target显示文摘Plant water use efficiency(WUE) is becoming a key issue in semiarid areas, where crop production relies on the use of large volumes of water. Improving WUE is necessary for securing environmental sustainability of food production in these areas. Given that climate change predictions include increases in temperature and drought in semiarid regions,improving crop WUE is mandatory for global food production. WUE is commonly measured at the leaf level, because portable equipment for measuring leaf gas exchange rates facilitates the simultaneous measurement of photosynthesis and transpiration. However,when those measurements are compared with daily integrals or whole-plant estimates of WUE, the two sometimes do not agree. Scaling up from single-leaf to whole-plant WUE was tested in grapevines in different experiments by comparison of daily integrals of instantaneous water use efficiency [ratio between CO2assimilation(AN) and transpiration(E); AN/E] with midday AN/E measurements, showing a low correlation, being worse with increasing water stress. We sought to evaluate the importance of spatial and temporal variation in carbon and water balances at the leaf and plant levels. The leaf position(governing average light interception) in the canopy showed a marked effect on instantaneous and daily integrals of leaf WUE. Night transpiration and respiration rates were also evaluated, as well as respiration contributions to total carbon balance. Two main components were identified as filling the gap between leaf and whole plant WUE: the large effect of leaf position on daily carbon gain and water loss and the large flux of carbon losses by dark respiration. These results show that WUE evaluation among genotypes or treatments needs to be revised. | Hipólito Medrano Magdalena Tomás Sebastià Martorell aume Flexas Esther Hernández Joan Rosselló Alicia Pou José-Mariano Escalona Josefina Bota | 2015 | The Crop Journal2015，3，3： | 9 |
| 14 | Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice显示文摘AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in mice.METHODS: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation. | Alfredo Santana Carlos Medina Maria Cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero | 2006 | World Journal of Gastroenterology2006，12，40： | 9 |
| 15 | 地下水人工回灌气相堵塞特征的试验研究显示文摘地下水人工回灌可以高效地利用雨季丰沛的水量来缓解地下水过量开采造成的海水入侵、泉水断流等环境水文地质问题,但回灌堵塞一直是制约人工回灌效率的关键问题。针对雨洪水回灌携带的大量气泡问题,设计室内砂柱试验模拟装置,利用曝气水进行人工回灌,定时记录试验过程中测压管读数及出流流量,利用达西定律计算各层渗透系数,研究气相堵塞的发展过程和规律。结果表明:回灌过程中由于气相堵塞导致含水层渗透系数随时间呈指数衰减,气相堵塞主要发生在介质浅表层(0~30 cm),且随时间有向下发展的趋势,堵塞速率随深度的增加逐渐减小,在回灌过程中适时停灌进行排气有利于减小气相堵塞对回灌效率的影响。 | 束龙仓 张永杰 许杨 吴佩鹏 Abunu Atlabachew Esther Chifuniro Mabedi | 2017 | 水科学进展2017，28，5： | 8 |
| 16 | Effects of Yiqi Huoxue Recipe (益气活血方) and Coxsackie Virus B Type 3 on the Expression of Ribosomal Protein S20 in Rat Cardiac Myocytes显示文摘<正>Objective:To study the effects of Yiqi Huoxue Recipe(益气活血方) and Coxsackie B virus type 3(CVB3) on the expression of ribosomal protein S20 in rat cardiac myocytes,to explore the pathogenesis of myocarditis induced by CVB3 and the mechanism of Yiqi Huoxue Recipe on gene level,and to further investigate whether Yiqi Huoxue Recipe is an effective prescription for CVB3 myocarditis.Methods:A modified suppression subtractive hybridization(SSH) was used to isolate differentially expressed genes between the CVB3 infection group and the treatment group with Yiqi Huoxue Recipe.The results were further verified by fluorescence RT-PCR.Results:The results of SSH showed that the gene expression of ribosomal protein S20 in the treatment group was higher than that in the CVB3 infection group(P<0.05),which agreed with the results of fluorescent RT-PCR.Conclusion:Down-regulation of ribosomal protein S20 mRNA expression might be one of the mechanisms in CVB3 myocarditis,and Yiqi Huoxue Recipe could achieve the treatment of viral myocarditis by regulating the expression of ribosomal protein S20. | ZHANG Ming-xue ZHANG Yu-mei Esther Jun HE Wei CHE Hong-hua GU Ping | 2011 | Chinese Journal of Integrative Medicine2011，17，5： | 8 |
| 17 | 摩擦堆焊法在Ti-6Al-4V表面制备的AA2124/4wt.%B4C纳米复合涂层的显微组织和磨损特性(英文)显示文摘为了提高Ti-6Al-4V的耐磨性,运用摩擦堆焊法在其表面制备AA2124/4wt.%B4C纳米复合涂层。采用传统搅拌铸造方法制备复合材料,然后用自主研发的摩擦堆焊机在不同的转速下进行涂覆。采用传统和先进显微技术对复合镀层的显微组织进行观察,采用销-盘装置对制备材料的滑动磨损性能进行评价。复合涂层的厚度和宽度均随转速的增加而增加。涂层与基体的界面呈直线,未观察到厚的金属间层。结果还表明,纳米B4C粒子在复合涂层中分布均匀,晶粒细小,铝基体与B4C颗粒的界面结合良好。总之,该复合涂层由于其较小的有效接触面积,较低的摩擦因数和良好的界面结合性能,使钛合金基体的耐磨性得到提高。 | I. ESTHER I. DINAHARAN N. MURUGAN | 2019 | Transactions of Nonferrous Metals Society of China2019，29，6： | 8 |
| 18 | AA1060铝合金和C1100工业纯铜搅拌摩擦点焊的演变性能(英文)显示文摘采用搅拌摩擦点焊技术连接纯铜(C11000)和纯铝(AA1060)板材,并表征了焊缝的演变性能。在不同转速和送入深度下,采用不同形状刀具制备点焊焊缝。在焊缝两边可观察到不同长度铜环,这表明铜向前挤压进入铝板,有助于得到高强焊缝。采用能量散射谱和X射线衍射研究手段可观察到在铝基体中存在铜粒子,且有各种不同的金属间化合物存在。除了在转速800 r/min下采用锥形销和凹形肩得到的焊缝外,最大的拉伸断裂载荷随着送入深度的增加而增大。在剪切-拉伸载荷条件下,所有的搅拌摩擦点焊接头产生了点焊熔核滑脱失效模式。在样品锁眼附近得到了峰值硬度,这同焊接搅拌区存在金属间化合物有关。 | Mukuna P.MUBIAYI Esther T.AKINLABI | 2016 | Transactions of Nonferrous Metals Society of China2016，26，7： | 7 |
| 19 | Comparative Transcriptomic Analysis of Salt Adaptation in Roots of Contrasting Medicago truncatula Genotypes显示文摘进化差异能被和不同环境的植物的相互作用驾驶。涉及生态的改编到不能生活的限制的分子的底能用 genomic 工具被探索。荚是世界范围的主要庄稼,土壤咸度是在这些植物影响产量的一个主要压力。我们在 Medicago truncatula 荚分析了让对比回答腌应力的二遗传型的根 transcriptome:TN1.11,在咸突尼斯的土壤,和参考 Jemalong A17 遗传型取样了。TN1.11 植物在盐应力以及钠离子的微分累积下面看增加的根生长是否与 A17 相比。Transcriptomic 分析揭示了盐优先地在 TN1.11 的根顶调整的特定的基因簇,尤其是那些与植物生长素小径有关并且到在 histone 变体 isoforms 的变化。编码抄写因素(TF ) 的许多基因也是响应盐在二遗传型之间调整的差别。在为功能的研究选择的那些之中,在大多数差别在遗传型之间调整了的 bHLH 类型 TF 的 A17 遗传型的根的 overexpression 显著地在盐应力下面改进了根生长。尽管有微分 transcriptional 回答的全球复杂性,我们建议这 bHLH TF 表情的增加可以被连接到 M 的改编。truncatula 到盐的土壤环境。 | Ons Zahaf Sandrine Blanchet Axel de Zelicourt Benoit Alunni Julie Plet Carole Laffont Laura de Lorenzo Sandrine Imbeaud Jean-Laurent lchante Anouck Diet Mounawer Badri Ana Zabalza Esther M. Gonzalez Herve Delacroix Veronique Gruber Florian Frugier Martin Crespi | 2012 | Molecular Plant2012，5，5： | 7 |
| 20 | Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia显示文摘AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and colorectal neoplasia tissues from Puerto Ricans.METHODS:Tissues from patients with IBD,colitisassociated colorectal cancer(CAC),sporadic dysplasia,and sporadic colorectal cancer(CRC),as well as normal controls,were identified at several centers in Puerto Rico.Archival formalin-fixed,paraffin-embedded tissues were de-identified and processed by immunohistochemistry for NK-1R,p EGFR,Cox-2,and VDR.Pictures of representative areas of each tissues diagnosis were taken and scored by three observers using a4-point scale that assessed intensity of staining.Tissues with CAC were further analyzed by photographing representative areas of IBD and the different grades of dysplasia,in addition to the areas of cancer,within each tissue.Differences in the average age between the five patient groups were assessed with one-way analysis of variance and Tukey-Kramer multiple comparisons test.The mean scores for normal tissues and tissues with IBD,dysplasia,CRC,and CAC were calculatedand statistically compared using one-way analysis of variance and Dunnett’s multiple comparisons test.Correlations between protein expression patterns were analyzed with the Pearson’s product-moment correlation coefficient.Data are presented as mean±SE.RESULTS:On average,patients with IBD were younger(34.60±5.81)than normal(63.20±6.13,P<0.01),sporadic dysplasia(68.80±4.42,P<0.01),sporadic cancer(74.80±4.91,P<0.001),and CAC(57.50±5.11,P<0.05)patients.NK-1R in cancer tissue(sporadic CRC,1.73±0.34;CAC,1.57±0.53)and sporadic dysplasia(2.00±0.45)were higher than in normal tissues(0.73±0.19).p EGFR was significantly increased in sporadic CRC(1.53±0.43)and CAC(2.25±0.47)when compared to normal tissue(0.07±0.25,P<0.05,P<0.001,respectively).Cox-2 was significantly increased in sporadic colorectal cancer(2.20±0.23 vs 0.80±0.37 for normal tissues,P<0.05).In comparison to normal(2.80±0.13)and CAC(2.50±0.33)tissues,VDR was significantly decreased in sporadic dysplasia(0.00±0.00,P<0.001 vs normal,P<0.001 vs CAC)and sporadic CRC(0.47±0.23,P<0.001 vs normal,P<0.001 vs CAC).VDR levels negatively correlated with NK-1R(r=-0.48)and p EGFR(r=-0.56)in normal,IBD,sporadic dysplasia and sporadic CRC tissue,but not in CAC.CONCLUSION:Immunohistochemical NK-1R and p EGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia.VDR immunoreactivity can distinguish CAC from sporadic cancer. | Raymond A Isidro Myrella L Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard | 2015 | World Journal of Gastroenterology2015，21，6： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员