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| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK显示文摘Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia(T-ALL) cells and potential molecular mechanisms. Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. Western blotting was performed for detecting changes of apoptosis-associated proteins, cell cycle regulatory proteins and state of activation of Akt, mTOR, p70S6K, 4E-BP1, and p38-MAPK. Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase(CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. Western blotting revealed that resveratrol significantly decreased the expression of antiapoptotic proteins(Mcl-1 and Bcl-2) and increased the expression of proapoptotic proteins(Bax, Bim, and Bad), and induced cleaved-caspase-3 in a time-dependent manner. Significant increase in ratio of LC3-II/LC3-I and Beclin 1 was also detected. Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced.Conclusion Our findings have suggested that resveratrol induces cell cycle arrest,apoptosis,and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways.Autophagy might play a role as a self-defense mechanism in T-ALL cells treated by resveratrol.Therefore,the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. | GE Jiao LIU Yan LI Qiang GUO Xia GU Ling MA Zhi Gui ZHU Yi Ping | 2013 | Biomedical and Environmental Sciences2013，26，11： | 38 |
| 3 | Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions显示文摘AIM:To evaluate whether celecoxib,a selective cyclooxygenase 2(COX-2) inhibitor,could reduce the severity of gastric precancerous lesions following Helicobacter pylori(H pylori) eradication.METHODS:H pylori-eradicated patients with gastric precancerous lesions randomly received either celecoxib(n=30) or placebo(n=30) for up to 3 mo.COX-2 expression and activity was determined by immunostaining and prostaglandin E2(PGE2) assay,cell proliferation by Ki-67 immunostaining,apoptosis by TUNEL staining and angiogenesis by microvascular density(MVD) assay using CD31 staining.RESULTS:COX-2 protein expression was significantly increased in gastric precancerous lesions(atrophy,intestinal metaplasia and dysplasia,respectively) compared with chronic gastritis,and was concomitant with an increase in cell proliferation and angiogenesis.A significant improvement in precancerous lesions was observed in patients who received celecoxib compared with those who received placebo(P<0.001).Of these three changes,84.6% of sites with dysplasia regressed in patients treated with celecoxib(P=0.002) compared with 60% in the placebo group,suggesting that celecoxib was effective on the regression of dysplasia.COX-2 protein expression(P<0.001) and COX-2 activity(P<0.001) in the gastric tissues were consistently lower in celecoxib-treated patients compared with the placebo-treated subjects.Moreover,it was also shown that celecoxib suppressed cell proliferation(P<0.01),induced cell apoptosis(P<0.01) and inhibited angiogenesis with decreased MVD(P<0.001).However,all of these effects were not seen in placebo-treated subjects.Furthermore,COX-2 inhibition resulted in the up-regulation of PPARγ expression,a protective molecule with anti-neoplastic effects.CONCLUSION:H pylori eradication therapy followed by celecoxib treatment improves gastric precancerous lesions by inhibiting COX-2 activity,inducing apoptosis,and suppressing cell proliferation and angiogenesis. | Li-Jing Zhang Shi-Yan Wang Xiao-Hui Huo Zhen-Long Zhu Jian-Kun Chu Jin-Cheng Ma Dong-Sheng Cui Ping Gu Zeng-Ren Zhao Ming-Wei Wang Jun Yu | 2009 | World Journal of Gastroenterology2009，15，22： | 32 |
| 4 | Ultrahigh performance concrete–properties, applications and perspectives显示文摘Over the last twenty years,remarkable advances have taken place in the research and application of ultra-high performance concrete(UHPC),which exhibits outstanding mechanical properties and excellent durability.It has shown great potential for the next generation infrastructure construction from the sustainability point of view.This paper will give an overview on UHPC,with particular focus on the properties,applications and perspectives.After several decades of development,several types of commercial UHPC materials are available in the market,and the properties of UHPC have been characterized by numerous experimental and field tests.Generally speaking,the performance(e.g.mechanical properties and durability)of UHPC is much better than normal concrete(NC)and high performance concrete(HPC).Therefore,the uses of UHPC are growing all over the world,in both fields of new construction and retrofitting.Nevertheless,it is still a special material and technology,which is not worldwide accepted.So some application prospects of UHPC are briefly introduced in the paper,and the efforts,which have to be made to turn UHPC into a widespread‘regular’technology,are discussed.This paper aims to help designers,engineers,architects and infrastructure owners to know the capacities of UHPC and thus to increase the applications of this material. | GU Chun Ping YE Guang SUN Wei | 2015 | Science China(Technological Sciences)2015，58，4： | 28 |
| 5 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 6 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 7 | Antisense to cyclin D1 reverses the transformed phenotype of human gastric cancer cells显示文摘INTRODUCTIONStudiesonthefunctionsofcelularprotooncogenesandtumorsuppresorgenesindicatethatmostofthesegenesmediatesignaltrans... | CHEN Bing 1, ZHANG Xue Yong 2, ZHANG Yu Jing 3, ZHOU Ping 3, GU Yan 4 and FAN Dai Ming 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 23 |
| 8 | LHD1,an Allele of DTH8/Ghd8,Controls Late Heading Date in Common Wild Rice (Oryza rufipogon)显示文摘Flowering at suitable time is very important for plants to adapt to complicated environments and produce their seeds successfully for reproduction.In rice (Oryza rufipogon Griff.) photoperiod regulation is one of the important factors for controlling heading date.Common wild rice,the ancestor of cultivated rice,exhibits a late heading date and a more sensitive photoperiodic response than cultivated rice.Here,through map-based cloning,we identified a major quantitative trait loci (QTL) LHD1 (Late Heading Date 1),an allele of DTH8/Ghd8,which controls the late heading date of wild rice and encodes a putative HAP3/NF-YB/CBF-A subunit of the CCAAT-box-binding transcription factor.Sequence analysis revealed that several variants in the coding region of LHD1 were correlated with a late heading date,and a further complementary study successfully rescued the phenotype.These results suggest that a functional site for LHD1 could be among those variants present in the coding region.We also found that LHD1 could down-regulate the expression of several floral transition activators such as Ehd1,Hd3a and RFT1 under long-day conditions,but not under short-day conditions.This indicates that LHD1 may delay flowering by repressing the expression of Ehd1,Hd3a and RFT1 under long-day conditions. | Xiaodong Dai Younian Ding Lubin Tan Yongcai Fu Fengxia Liu Zuofeng Zhu Xianyou Sun Xuewen Sun Ping Gu Hongwei Cai Chuanqing Sun | 2012 | Journal of Integrative Plant Biology2012，54，10： | 23 |
| 9 | The application of nanoparticles in cancer immunotherapy:Targeting tumor microenvironment显示文摘The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment(TME).Recently,TME modulation strategies have attracted much attention in cancer immunotherapy.Despite the preliminary success of immunotherapeutic agents,their therapeutic effects have been restricted by the limited retention time of drugs in TME.Compared with traditional delivery systems,nanoparticles with unique physical properties and elaborate design can efficiently penetrate TME and specifically deliver to the major components in TME.In this review,we briefly introduce the substitutes of TME including dendritic cells,macrophages,fibroblasts,tumor vasculature,tumor-draining lymph nodes and hypoxic state,then review various nanoparticles targeting these components and their applications in tumor therapy.In addition,nanoparticles could be combined with other therapies,including chemotherapy,radiotherapy,and photodynamic therapy,however,the nanoplatform delivery system may not be effective in all types of tumors due to the heterogeneity of different tumors and individuals.The changes of TME at various stages during tumor development are required to be further elucidated so that more individualized nanoplatforms could be designed. | Muyue Yang Jipeng Li Ping Gu Xianqun Fan | 2021 | Bioactive Materials2021，6，7： | 21 |
| 10 | Multiple imaging techniques in the diagnosis of ampullary carcinoma显示文摘BACKGROUND:Ampullary carcinoma is a neoplasia with a good prognosis compared to pancreatic cancer. But it is difficult to early diagnose because it lacks clear clinical symptoms.This study aimed to evaluate the efficacy of abdominal ultrasonography(US),enhanced computed tomography(CT),magnetic resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)in detecting ampullary carcinoma. METHODS:Forty-one patients with ampullary carcinoma who had been confirmed pathologically among the inpatients at the First Affiliated Hospital of Zhejiang University School of Medicine from February 2003 to March 2007 were analyzed retrospectively.The accuracy of US,CT,MRCP and ERCP were compared in the diagnosis of ampullary carcinoma. RESULTS:The accurate rate for detection of ampullary carcinoma with US was 26.83%.The accuracy of CT and ERCP in detection of ampullary tumors was 84.62%and 100%,respectively,which were significantly higher than that of US(P<0.05).The accuracy of MRCP in detection of ampullary tumors was similar to that of US in spite of visualization of obstruction and dilatation of the pancreaticobiliary duct with MRCP. CONCLUSIONS:Because of the obscure and late onset of symptoms,ampullary carcinoma is difficult to diagnose early.Multiple imaging techniques should be carried out appropriately in order to early diagnose the disease and improve the prognosis. | Chen, Wei-Xing Xie, Qi-Gui Zhang, Wei-Fang Zhang, Xian Hu, Tian-Tian Xu, Ping Gu, Zhu-Ying | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 20 |
| 11 | Lightweight,Flexible Cellulose-Derived Carbon Aerogel@Reduced Graphene Oxide/PDMS Composites with Outstanding EMI Shielding Performances and Excellent Thermal Conductivities显示文摘In order to ensure the operational reliability and infor-mation security of sophisticated electronic components and to protect human health,efficient electromagnetic interference(EMI)shielding materials are required to attenuate electromagnetic wave energy.In this work,the cellulose solution is obtained by dissolving cotton through hydrogen bond driving self-assembly using sodium hydroxide(NaOH)/urea solution,and cellulose aerogels(CA)are prepared by gelation and freeze-drying.Then,the cellulose carbon aerogel@reduced graphene oxide aerogels(CCA@rGO)are prepared by vacuum impregnation,freeze-drying followed by thermal annealing,and finally,the CCA@rGO/polydimethylsiloxane(PDMS)EMI shielding composites are prepared by backfilling with PDMS.Owing to skin-core structure of CCA@rGO,the complete three-dimensional(3D)double-layer con-ductive network can be successfully constructed.When the loading of CCA@rGO is 3.05 wt%,CCA@rGO/PDMS EMI shielding composites have an excellent EMI shielding effectiveness(EMI SE)of 51 dB,which is 3.9 times higher than that of the co-blended CCA/rGO/PDMS EMI shielding composites(13 dB)with the same loading of fillers.At this time,the CCA@rGO/PDMS EMI shielding composites have excellent thermal stability(T_(HRI) of 178.3℃)and good thermal conductivity coefficient(λ of 0.65 W m^(-1) K^(-1)).Excellent comprehensive performance makes CCA@rGO/PDMS EMI shielding composites great prospect for applications in lightweight,flexible EMI shielding composites. | Ping Song Bei Liu Chaobo Liang Kunpeng Ruan Hua Qiu Zhonglei Ma Yongqiang Guo Junwei Gu | 2021 | Nano-Micro Letters2021，13，6： | 19 |
| 12 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 13 | The estimate of sea ice resources quantity in the Bohai Sea based on NOAA/AVHRR data显示文摘The research on sea ice resources is the academic base of sea ice exploitation in the Bohai Sea. According to the ice-water spectrum differences and the correlation between ice thickness and albedo, this paper comes up with a sea ice thickness inversion model based on the NOAA/AVHRR data. And then a sea ice resources quantity (SIQ) time series of Bohai Sea is established from 1987 to 2009. The results indicate that the average error of inversion sea ice thickness is below 30%. The maximum sea ice resources quantity is about 6 × 10 9 m 3 and the minimum is 1.3 × 10 9 m 3 . And a preliminary analysis has been made on the errors of the estimate of sea ice resources quantity (SIQ). | YUAN Shuai GU Wei XU Yingjun WANG Ping HUANG Shuqing LE Zhangyan CONG Jianou | 2012 | Acta Oceanologica Sinica2012，31，1： | 15 |
| 14 | Chromosomal level assembly and population sequencing of the Chinese tree shrew genome显示文摘Chinese tree shrews (Tupaia belangeri chinensis) have become an increasingly important experimental animal in biomedical research due to their close relationship to primates. An accurately sequenced and assembled genome is essential for understanding the genetic features and biology of this animal. In this study, we used long-read single-molecule sequencing and high-throughput chromosome conformation capture (Hi-C) technology to obtain a high-qualitychromosome-scale scaffolding of the Chinese tree shrew genome. The new reference genome (KIZ version 2: TS_2.0) resolved problems in presently available tree shrew genomes and enabled accurate identification of large and complex repeat regions, gene structures, and species-specific genomic structural variants. In addition, by sequencing the genomes of six Chinese tree shrew individuals, we produced a comprehensive map of 12.8 M single nucleotide polymorphisms and confirmed that the major histocompatibility complex (MHC) loci and immunoglobulin gene family exhibited high nucleotide diversity in the tree shrew genome. We updated the tree shrew genome database (TreeshrewDB v2.0: http://gffzzb70c77447da74c53hnunuxc0vb5qf669n.ffgz.tsg.suse.edu.cn) to include the genome annotation information and genetic variations. The new high-quality reference genome of the Chinese tree shrew and the updated TreeshrewDB will facilitate the use of this animal in many different fields of research. | Yu Fan Mao-Sen Ye Jin-Yan Zhang Ling Xu Dan-Dan Yu Tian-Le Gu Yu-Lin Yao Jia-Qi Chen Long-Bao Lv Ping Zheng Dong-Dong Wu Guo-Jie Zhang Yong-Gang Yao | 2019 | Zoological Research2019，40，6： | 15 |
| 15 | Liver Enzymes Concentrations Are Closely Related to Pre-diabetes:Findings of the Shanghai Diabetes Study Ⅱ (SHDS Ⅱ)显示文摘Objective To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.Methods A total of 3 756 participants were enrolled.Each participant underwent an oral glucose tolerance test and completed a questionnaire.Anthropometric indices were recorded and serum samples were collected for measurement.Results Liver enzymes concentrations were independently associated with i-IGT,IFG+IGT,and diabetes.With the increase of ALT and GGT concentrations,ORs for i-IGT,IFG+IGT,and diabetes increased gradually.By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1),ORs for i-IGT,IFG+IGT,or diabetes was significant after adjustment.Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI):2.56 (1.51-4.34) P=0.00;GGT OR (95% CI):2.66 (1.53-4.65) P=0.00].Conclusion Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. | GAO Fei PAN Jie Min HOU Xu Hong FANG Qi Chen LU Hui Juan TANG Jun Ling GU Hui Lin PAN Zhi Jian YAO You Hua SHEN Wei Zhen JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 15 |
| 16 | Natural Variations at TIG1 Encoding a TCP Tran scription Factor Contribute to Plant Architecture Domestication in Rice显示文摘The modification of plant architecture is a crucial target in rice domestication and modern genetic improvement.Although several genes regulating rice plant architecture have been characterized,the molecular mechanisms underlying rice plant architecture domestication remain largely unclear.Here we show that the inclined tiller growth in wild rice is controlled by a single dominant gene,TILLER INCLINED GROWTH 1 (T/Gf),which is located on chromosome 8 and encodes a TCP transcriptional activator.TIG1 is primarily expressed in the adaxial side of the tiller base,promotes cell elongation,and enlarges the tiller angle in wild rice.Variations in the TIG1 promoter of indica cultivars {tig1 allele) resulted in decreased expression of TIG1 in the adaxial side of tiller base and reduced cell length and tiller angle,leading to the transition from inclined tiller growth in wild rice to erect tiller growth during rice domestication.TIG1 positively regulates the expression of EXP A3,EXPB5,and SAUR39 to promote cell elongation and increase the tiller angle.Selective sweep analysis revealed that the tig1 allele was selected in indica cultivars by human beings.The cloning and characterization of TIG1 supports a new scenario of plant architecture evolution in rice. | Weifeng Zhang Lubin Tan Hongying Sun Xinhui Zhao Fengxia Liu Hongwei Cai Yongcai Fu Xianyou Sun Ping Gu Zuofeng Zhu Chuanqing Sun | 2019 | Molecular Plant2019，12，8： | 13 |
| 17 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 18 | 3D Shapeable,Superior Electrically Conductive Cellulose Nanofibers/Ti_(3)C_(2)T_(x) MXene Aerogels/Epoxy Nanocomposites for Promising EMI Shielding显示文摘In this work,3D highly electrically conductive cellulose nanofibers(CNF)/Ti_(3)C_(2)T_(x) MXene aerogels(CTA)with aligned porous structures are fabricated by directional freezing followed by freeze-drying technique,and the thermally annealed CTA(TCTA)/epoxy nanocomposites are then fabricated by thermal annealing of CTA,subsequent vacuum-assisted impregnation and curing method.Results show that TCTA/epoxy nanocomposites possess 3D highly conductive networks with ultralow percolation threshold of 0.20 vol%Ti_(3)C_(2)T_(x).When the volume fraction of Ti_(3)C_(2)T_(x) is 1.38 vol%,the electrical conductivity(σ),electromagnetic interference shielding effectiveness(EMI SE),and SE divided by thickness(SE/d)values of the TCTA/epoxy nanocomposites reach 1672 Sm-1,74 dB,and 37 dBmm-1,respectively,which are almost the highest values compared to those of polymer nanocomposites reported previously at the same filler content.In addition,compared to those of the samples without Ti_(3)C_(2)T_(x),the storage modulus and heat-resistance index of TCTA/epoxy nanocomposites are enhanced to 9792.5 MPa and 310.7℃,increased by 62%and 6.9℃,respectively,presenting outstanding mechanical properties and thermal stabilities.The fabricated lightweight,easy-to-process,and shapeable TCTA/epoxy nanocomposites with superior EMI SE values,excellent mechanical properties,and thermal stabilities greatly broaden the applications of MXene-based polymer composites in the field of EMI shielding. | Lei Wang Ping Song Cheng-Te Lin Jie Kong Junwei Gu | 2020 | Research2020，，1： | 13 |
| 19 | High-Efficiency Electromagnetic Interference Shielding of rGO@FeNi/Epoxy Composites with Regular Honeycomb Structures显示文摘With the rapid development of fifth-generation mobile com-munication technology and wearable electronic devices,electromagnetic interference and radiation pollution caused by electromagnetic waves have attracted worldwide attention.Therefore,the design and development of highly efficient EMI shielding materials are of great importance.In this work,the three-dimensional graphene oxide(GO)with regular honeycomb structure(GH)is firstly constructed by sacrificial template and freeze-dry-ing methods.Then,the amino functionalized FeNi alloy particles(f-FeNi)are loaded on the GH skeleton followed by in-situ reduction to prepare rGH@FeNi aerogel.Finally,the rGH@FeNi/epoxy EMI shielding com-posites with regular honeycomb structure is obtained by vacuum-assisted impregnation of epoxy resin.Benefitting from the construction of regular honeycomb structure and electromagnetic synergistic effect,the rGH@FeNi/epoxy composites with a low rGH@FeNi mass fraction of 2.1 wt%(rGH and f-FeNi are 1.2 and 0.9 wt%,respectively)exhibit a high EMI shielding effectiveness(EMI SE)of 46 dB,which is 5.8 times of that(8 dB)for rGO/FeNi/epoxy composites with the same rGO/FeNi mass fraction.At the same time,the rGH@FeNi/epoxy composites also possess excellent thermal stability(heat-resistance index and temperature at the maximum decomposition rate are 179.1 and 389.0°C respectively)and mechanical properties(storage modulus is 8296.2 MPa). | Ping Song Zhonglei Ma Hua Qiu Yifan Ru Junwei Gu | 2022 | Nano-Micro Letters2022，14，3： | 13 |
| 20 | Clinical application of simultaneous detection of cystatin C,cathepsin S,and IL-1 in classification of coronary artery disease显示文摘Cystatin C,cathepsin S,and IL-1 are three important biomarkers of atherosclerosis.Previous studies emphasized the relationship between individual biomarkers in coronary artery disease(CAD) patients and severity of atherosclerostic lesions of the coronary arteries,while combined cystatin C,cathepsin S,and IL-1 have not been reported for clinical classification of CAD.We aimed to establish a link between cystatin C,cathepsin S,IL-1 and CAD in this cohort study.Totally 112 subjects were enrolled and divided into the stable angina pectoris group,the unstable angina pectoris group and the acute myocardial infarction(AMI) groups,and 50 healthy adults served as controls.The levels of the three biomarkers were detected by ELISA.The results showed that serum level of cystatin C(mg/L) was higher in CAD patients compared with those in the healthy controls(AMI vs.unstable angina pectoris vs.stable angina pectoris vs.controls:1.27±0.18 vs.1.09±0.19 vs.0.91±0.05 vs.0.78±0.07,all P<0.01).Cathepsin S(ng/mL) was also significantly different among the groups(AMI vs.unstable angina pectoris vs.stable angina pectoris vs.controls:67.30±8.36 vs.56.90±7.16 vs.49.8±2.72 vs.67.30±8.36,all P<0.01).IL-1(pg/mL) was significantly different among the groups as well(AMI vs.unstable angina pectoris vs.stable angina pectoris vs.controls:2.96±0.57 vs.2.46±0.24 vs.2.28±0.09 vs.2.02±0.13,all P<0.01).Spearman's correlation test revealed positive correlation between cystatin C,cathepsin S,IL-1 and Gensini score(r=0.451,0.491,0.397,respectively).It is suggested that simultaneous detection of cystatin C,cathepsin S,and IL-1 in serum may be useful in clinical classification and assessment of severity of CAD. | Ling Yan Shuang Ding Bing Gu Ping Ma | 2017 | The Journal of Biomedical Research2017，31，4： | 12 |
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