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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Molecular recognition in a propazine-imprinted polymer and its application to the determination of triazines in environmental samples 显示文摘 | Turiel E Esteban A M Fernández P | 2001 | Anal Chem2001，75，21： | 2 |
| 4 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 5 | On the measurement of polarization显示文摘 | ESTEBAN P RAY D | 1994 | Econometrica1994，，4： | 1 |
| 6 | Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy显示文摘 | Thille AW Esteban A Femdndez-Segoviano P | 2013 | Am J Respir Crit Care Med2013，187，7： | 1 |
| 7 | Therapeutics and vaccines against chikungunya virus 显示文摘 | Ahola T Couderc T Courderc T Ng LF Halleng/ird D Powers A Leeuit M Esteban M Merits A Roques P Liljestr6m P | 2015 | Vector Borne Zoonotic Dis2015，15，4： | 1 |
| 8 | A Continum Theory for Dynamic Recrystallization with Microstructure-related Length Scales 显示文摘 | Esteban Busso P | 1998 | International Journal of Plasticity1998，14，4： | 1 |
| 9 | Kinetics of mercury uptake by oilseed rape and white lupin:influence of Mn and Cu显示文摘 | Esteban E Deza MJ Zornoza P | 2013 | Acta Physiologiae Plantarum2013，35，7： | 1 |
| 10 | Biocatalysis : towards ever greener biodiesel production 显示文摘 | ROBLES - MEDINA A GONZ:LEZ - MORENO P A ESTEBAN - CERDAN L | 2009 | Biotechnol Adv2009，27，4： | 1 |
| 11 | STR genetic diversity in a Mediterranean population from the south of the Iberian Peninsula 显示文摘 | Gaibar M Esteban E Moral P | 2010 | Ann Hum Biol2010，37，2： | 1 |
| 12 | Nutritional value of edible insect from the state of Oaxaca, Mexico显示文摘 | JULIETA R E JOSE M P M ESTEBAN E P | 1997 | Journal of Food Composition and Analysis1997，10，2： | 1 |
| 13 | Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings显示文摘 | Esteban A Fernandez-Segoviano P Frutos-Vivar F | 2004 | Ann Intern Med2004，141，： | 1 |
| 14 | Multi-view stereo viavolumetric graph-cuts and occlusion robust photo-consistency显示文摘 | Vogiatzis G Esteban C H Torr P | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，12： | 1 |
| 15 | New therapeutic perspectives in HBV : when to stop NA s显示文摘 | Cristina Pérez‐Cameo Mònica Pons Rafael Esteban | 2014 | Liver Int2014，，： | 1 |
| 16 | An HIV-1 clade C DNA prime,NYVAC boost vaccine regimen induces reliable,polyfunctional,and long-lasting T cell responses显示文摘 | Harari A Bart PA St(o)hr W Tapia G Garcia M Medjitna-Rais E Burnet S Cellerai C Erlwein O Barber T Moog C Liljestrom P Wagner R Wolf H Kraehenbuhl JP Esteban M Heeney J Frachette MJ Tartaglia J McCormack S Babiker A Weber J Pantaleo G | 2008 | J Exp Med2008，205，1： | 1 |
| 17 | Break through Volumes increased by the assition of salt in the on - line solid - phase extraction and liquid chromatography of pesticides in environ - mental water 显示文摘 | Martin - Esteban A Fernandez P Cam atra C | | intern J Environ Ana]ytica Chemica Acta0，，： | 1 |
| 18 | Prosthetic mitral valve endocarditis due to Ochrobac- trumanthropi : ease report显示文摘 | Romero Gomez M P Peinado Esteban A M Sobrino Daza J A etal | 2004 | J Clin Mierobiol2004，42，7： | 1 |
| 19 | Situs inversus totalla and abdominal aortic aneurysm: Surgical repair of an extremely uncommon association显示文摘 | Riem Hem(mdez C Prez Rsmfrez P Esteban Graoia C | 2015 | Int J Surg Case Rep2015，10，： | 1 |
| 20 | Prevalence of sarcomcre protein gene mutations in preadolescent children with hypertro- phic cardiomyopathy 显示文摘 | Kaski JP Syrris P Esteban MT | 2009 | Circ Cardiovasc Genet2009，2，5： | 1 |
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