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| 1 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Existence of weak solutions for the motion of rigid bodies in a viscous fluid 显示文摘 | DESJARDINS B ESTEBAN M J | 1999 | Archive Rat Mech Anal1999，146，： | 1 |
| 4 | Introducing of apoptosis by the dsRNA dependent protein kinase (PKR): mechanism of action 显示文摘 | Gil J Esteban M | 2000 | Apoptosis2000，5，2： | 1 |
| 5 | Inflammation and angiotensin Ⅱ显示文摘 | Suzuki Y Ruiz-Ortega M Lorenzo O Ruperez M Esteban V Egido J | 2003 | Int J Biochem Cell Biol2003，35，： | 1 |
| 6 | Generation of induced pluripotent stem cell lines from tibetan miniature pig 显示文摘 | Esteban MA Xu J Yang J | 2009 | J Biol Chem2009，284，17： | 1 |
| 7 | Characterization of the surface tension of vegetable oils to be used as fuel in diesel engines 显示文摘 | Esteban B Riba J R Baquero G | 2012 | Fuel2012，102，2： | 1 |
| 8 | Conventional and molecular diagnostic strateg/es for prosthetic joint infections 显示文摘 | Esteban J Sorli L Alentorn-Geli E | 2014 | Expert Rev Mol Diagn2014，14，1： | 1 |
| 9 | Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal - cell carcinoma treated with first - line sunitinib : a muhicentre, observational, prospective study 显示文摘 | GARCIA - DONAS J ESTEBAN E LEANDRO - GARCIA L J | 2011 | Lancet Oncol2011，12，12： | 1 |
| 10 | Evaluation of hepatic fibrosis by transient elastography (fibroscan)in methotrexate-treated patients 显示文摘 | Barbero-Villares A Mendoza J Esteban C | 2009 | Hepatology2009，50，： | 1 |
| 11 | On weak solutions for fluidrigid structure interaction: compressible and incompressible models显示文摘 | DESJARDINS B ESTEBAN M J | 2000 | Comm Partial Diff Eqns2000，25，： | 1 |
| 12 | Systemic hemodynamics, gastric intramucosal PCO2 changes, and outcome in critically ill burn patients 显示文摘 | LOTENTE J A EZPELETA A ESTEBAN A | 2000 | Crit Care Med2000，28，： | 1 |
| 13 | On the measurement of polarization显示文摘 | ESTEBAN J RAY D | 1994 | Econometrica1994，62，： | 1 |
| 14 | Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants显示文摘 | Jardi R Buti M Rodriguez FF Cotrina M Costa X Pascual C Esteban R Guardia J | | 0，，： | 1 |
| 15 | The regulation of the imflammatory response through nuclear factor-kappaB pathway by angiotensin IV extends the role of the renin?angiotensin system in cardiovascular diseases显示文摘 | Ruiz-Ortega M Esteban V Egido J | 2007 | Trends CardiovascMed2007，17，1： | 1 |
| 16 | On the Measurement of Polarization显示文摘 | Esteban J E Ray D | | 0，，04： | 1 |
| 17 | Production of triacylglycerols rich in palmitic acid at position 2 as intermediates for the synthesis of human milk fat substitutes by enzymatic acidolysis显示文摘 | JIM(E)NEZ M J ESTEBAN L ROBLES A | | 0，，： | 1 |
| 18 | Hepatitis C virus(HCV)circulates as a population of different but closely related genomes:quasispecies nature of HCV genome distribution显示文摘 | Martell M Esteban J I Quer J | 1992 | J Virol1992，66，： | 1 |
| 19 | Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations显示文摘 | Campagnolo E R Johnson K R Karpati A Rubin C S Kolpin D W Meyer M T Esteban J E Currier R W Smith K Thu K M McGeehin M | | 0，，： | 1 |
| 20 | The changing epidemiology of hepatitis C virus infection in Europe 显示文摘 | Esteban J I Sauleda S Quer J | 2008 | J Hepatol2008，48，14： | 1 |
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