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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | The psychometric properties of the St George's Respiratory Questionnaire(SGRQ)in patients with idiopathic pulmonary fibrosis:a literature review显示文摘 | Swigris J J Esser D Conoscenti C S | 2014 | Health Qual Life Outcomes2014，12，1： | 1 |
| 3 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague S | 2008 | Kidney Int2008，73，11： | 1 |
| 4 | BAG-I-a nucleotide exchange factor of Hsc70 with multiple cellular functions显示文摘 | Alberti S Esser C Hohfeld J | 2003 | Cell Stress chaperones2003，8，： | 1 |
| 5 | Beta 2-microglobulin stimulates os- teoclast formation显示文摘 | Menaa C Esser E Sprague S M | 2008 | Kidney Int2008，73，11： | 1 |
| 6 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | MENAA C ESSER E SPRAGUE S M | 2008 | Kidney Int2008，73，11： | 1 |
| 7 | CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes显示文摘 | Stutte S Jux B Esser C | 2008 | J Invest Dermatol2008，128，6： | 1 |
| 8 | Ubiquitylation of BAG-1 Suggest a Novel Regulatory Mechanism during the Sorting of Chaperone Substrates to the Proteasome显示文摘 | Alberti S Demand J Esser C | 2002 | J Biol Chem2002，277，45： | 1 |
| 9 | Interaction of manufacturing process and machine tool 显示文摘 | Brecher C Esser M Witt S | 2009 | CIRP Annals-Manufacturing Technology2009，8，： | 1 |
| 10 | BAG-1-a nucleotide exchange factor of Hsc70 with multiple cellular functions显示文摘 | Alberti S Esser C Hohfeld J | 2003 | Cell Stress Chaperones2003，8，3： | 1 |
| 11 | Comments on the role of the cyst in the life cycle and survival of free-living protozoa 显示文摘 | CORLISS J O ESSER S C | 1974 | Trans Amer Micro Soc1974，93，： | 1 |
| 12 | BAG-1-a nucleotide exchange factor of Hsc70 with multiple cellular functions 显示文摘 | Alberti S Esser C Hohfeld J | 2003 | Cell Stress Chaperones2003，8，3： | 1 |
| 13 | Interaction of manufacturing process and machine tool显示文摘 | BRECHER C ESSER M WITT S | 2009 | CIRP Annals-Manufacturing Technology2009，58，2： | 1 |
| 14 | Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome显示文摘 | Alberti S Demand J Esser C | 2002 | Journal of Biological Chemistry2002，277，45： | 1 |
| 15 | Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome显示文摘 | Alberti S Demand J Esser C | 2002 | Journal of Biological Chemistry2002，277，45： | 1 |
| 16 | Beta 2-microglobulin stimulat- es osteoclast formation显示文摘 | Menaa C Esser E Sprague S | 2008 | Kidney Int2008，73，11： | 1 |
| 17 | Generation of alphabeta T-cell receptor + CD4 - CD8 + cells in major histocompatibility complex class I- deficient mice upon activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin 显示文摘 | Kronenberg S Lai Z Esser C | 2000 | Immunology2000，100，2： | 1 |
| 18 | Effects of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, given at post-puberty, in senescent mice 显示文摘 | Esser C Steinwachs S Herder C | 2005 | Toxicol Lett2005，157，2： | 1 |
| 19 | The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family显示文摘 | Jeon M S Esser C | 2000 | J Immunol2000，165，12： | 1 |
| 20 | Mechanisms of chemical- induced innate immunity in allergic contact dermatitis 显示文摘 | MARTIN S F ESSER P R WEBER F C | 2011 | Allergy2011，66，9： | 1 |
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