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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Waterbased crosslinkable surface coatings 显示文摘 | Richard J Esser Janes E | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 3 | IF-Nalpha activates dormant haematopoietic stem cells in vivo 显示文摘 | ESSERS M A OFFNER S BLANCO-BOSE W E | 2009 | Nature2009，458，： | 1 |
| 4 | Waterbased crosslinkable surface coatings 显示文摘 | RICHARD J ESSER JAMES E DEVONA DAVE E S | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 5 | Wood anatomy of Oleaceae显示文摘 | Baas P Esser P M van den Western M E T ZANDEE M | 1988 | IAWA Bull1988，9，： | 1 |
| 6 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague S | 2008 | Kidney Int2008，73，11： | 1 |
| 7 | Development of a real-time quantitative assay for detection of Epstein-Barr virus显示文摘 | Niesters HG van Esser J Fries E | 2000 | J Clin Microbiol2000，38，2： | 1 |
| 8 | Waterbased Crosslinkable Surface Coatings显示文摘 | Richard J Esser James E | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 9 | Selective andro- gen receptor modulators: in vitro and in vivo metabolism and analysis显示文摘 | de Rijke E Essers ML Rijk JC | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess2013，30，9： | 1 |
| 10 | Beta 2-microglobulin stimulates os- teoclast formation显示文摘 | Menaa C Esser E Sprague S M | 2008 | Kidney Int2008，73，11： | 1 |
| 11 | Experiences with the Kirby-Bauer method of antibiotic susceptibility testing 显示文摘 | Esser V M Elefson D E | 1970 | Am J Clin Pathol1970，54，2： | 1 |
| 12 | The osmium isotopic composition of the continental crust显示文摘 | Esser B E Turekian K K | 1993 | Geochem Cosmochem Acta1993，57，： | 1 |
| 13 | Beta 2- microglobulin stimulates osteoclast formation显示文摘 | MENAA C ESSER E SPRAGUE S M | 2008 | Kidney Int2008，73，11： | 1 |
| 14 | Beta2-microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague SM | 2008 | Kidney Int2008，73，11： | 1 |
| 15 | Water based crosslinkable surface coatings显示文摘 | R J ESSER J E DEVONA D E SETZKE | 1999 | Progress in Organic Coatings1999，36，12： | 1 |
| 16 | A general framework for a class of first order primal-dual algorithms for convex optimization in imaging science 显示文摘 | Esser E Zhang X Chan T F | 2010 | SIAM Journal on Imaging Sciences2010，3，4： | 1 |
| 17 | 查看详情显示文摘 | Nielen M W F Lasaroms J J P Essers M L Oosterink J E Meijer T Sanders M B Zuidema T Stolker A A M | | 0，，01： | 1 |
| 18 | Epstein-Barr virus(EBV)reactivation is a frequent event after allogeneic stem celltransplantation(SCT)and quantitatively predictsEB V-Iymphoproliferative disease following T-cell-depleted SCT显示文摘 | van Esser JW van der Holt B Meijer E | 2001 | Blood2001，98，4： | 1 |
| 19 | Measurement of radiographic changes in adjuvant-induced arthritis in rats by quanitative image analysis显示文摘 | Esser R E Hildebrand A Angelo R A | 1995 | Arthritis Rheum1995，38，1： | 1 |
| 20 | Beta2-microglobulin stimulates osteoclast formation显示文摘 | Menaa C Esser E Sprague SM | 2008 | Kidney Int2008，73，11： | 1 |
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