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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A computer model for teaching the dynamic behavior of AC contac- tors显示文摘 | RUIZ J R ESPINOSA A G ROMERAL L | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 3 | 查看详情显示文摘 | Duclos S J Jayaraman A Espinosa G P Cooper A S Maines G R | | 0，，： | 1 |
| 4 | Transverse myelitis affect- ing more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients 显示文摘 | Espinosa G Mendizabal A Minguez S Ramo - Tello C Capellades J Olive A Cervera R | 2010 | Semin Arthritis Rheum2010，39，4： | 1 |
| 5 | Effect of endothelin-1 on neutrophil adhesion to endothelial cells and cell and perfused heart显示文摘 | Lopez Farre A Riesco A Espinosa G | 1993 | Circulation1993，88，： | 1 |
| 6 | Treatment of antineutrophil cytoplasmic antibody-associated vasculitis显示文摘 | Bosch X Guilabert A Espinosa G | 2007 | JAMA2007，298，6： | 1 |
| 7 | Mexico City Seismic Alert System显示文摘 | Espinosa Aranda J M Jimenez A Ibarrola G | 1995 | Seismological Research Letters1995，66，： | 1 |
| 8 | Cardiac toxicity secondary to long term treatment with chloroquine显示文摘 | Cervena A Espinosa G Cervena R | 2001 | Ann Rheum Dis2001，60，： | 1 |
| 9 | Vitamin D and benign prostatic hyperplasia-areview显示文摘 | ESPINOSA G ESPOSITO R KAZZAZI A | 2013 | Can J Urol2013，20，4： | 1 |
| 10 | Short?term wholesale funding and systemic risk: a global Co V aR approach显示文摘 | Lopez -Espinosa G Moreno A Rubia A | 2012 | Journal of Banking & Finance2012，36，12： | 1 |
| 11 | Product composition regions of single-feed reactive distillation columns: mixtures containing inerts显示文摘 | ESPINOSA J AGUIRRE P A PEREZ G A | 1995 | Ind Eng Chem Res1995，34，3： | 1 |
| 12 | A computer model forteaching the dynamic behavior of AC contactors 显示文摘 | Riba Ruiz J-R Espinosa A G | 2010 | IEEE Transactions on Education2010，53，2： | 1 |
| 13 | An approach based on analytical expressions for optimal location of voltage sags monitors显示文摘 | ESPINOSA J E HERNANDEZ A OLGUIN G | 2009 | IEEE Transactions on Power Delivery2009，24，4： | 1 |
| 14 | Necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy显示文摘 | Calaas-Continente A Espinosa M Manzano-García G | | 0，，： | 1 |
| 15 | Treatment of antineutrophil cytoplasmic antibody associated vasculitis:a systematic review显示文摘 | Bosch X Guilabert A Espinosa G | 2007 | JAMA2007，298，6： | 1 |
| 16 | Synthesis, Biological Activity, and Quantitative Structure-Activity Relationship Study of Azanaphthalimide and Arylnaphthalimide Derivatives显示文摘 | Bra(n) M.F Gradillas A Gómez A Acero N Linares F Mu(n)oz-Mingarro D.M Abradelo C Rey-Stolle F Yuste M Campos J Gallo M Espinosa A | | 0，，9： | 1 |
| 17 | Treatment of antineutrophil cytoplasmic antibody associated vasculitis:a systematic review显示文摘 | Bosch X Guilabert A Espinosa G | 2007 | JAMA2007，298，： | 1 |
| 18 | Cognitive, genetic, and brain perfusion factors associated with four year incidence of Alzheimer disease from mild cognitive impairment 显示文摘 | Alegret M Cuberas-Borros G Espinosa A | 2014 | J Alzheimers Dis2014，41，3： | 1 |
| 19 | Elementary excitations in a diluted antiferromagnetic Kagome lattice 显示文摘 | Ramirez A P Espinosa G P Cooper A S | 1992 | Phys Rev B1992，45，： | 1 |
| 20 | Petroleum geology of the Cusiana Field,Llanos Basin Foothills,Colombia显示文摘 | Cazier E C Hayward A B Espinosa G | | AAPG Bulletin0，79，10： | 1 |
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