|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 2 | European stroke prevention study显示文摘 | ESPS Group | 1990 | Stroke1990，21，8： | 2 |
| 3 | Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice显示文摘 | Bego?a Cerdá Rafael Llorach José J. Cerón Juan Carlos Espín Francisco A. Tomás-Barberán | 2003 | European Journal of Nutrition2003，，1： | 2 |
| 4 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 5 | Stress henodynamic and inhaled and intravenous anesthetic laparoscopic chloecystectomy显示文摘 | Grazida E Elena G Gobbo immunological techniques for Esp Anestesid responses to video-assisted M | 2005 | Rev Reanim2005，52，4： | 1 |
| 6 | Cardiovascular effects of epinephrine during rewarming from hypothermia in an intact animal model显示文摘 | Kondratiev TV Myhre ESP Simonsen Q | 2006 | Journal of Applied Physiology2006，100，2： | 1 |
| 7 | Myocardial infarction caused by coronary arterymyocardial bridge 显示文摘 | Bashour TT Esp inosa E Blumenthal J | 1997 | Am Heart J1997，133，4： | 1 |
| 8 | Expandable versus nonexpandable cages for thoracolumbar burst fracture 显示文摘 | Eleraky MA Duong HT Esp E | 2011 | World Neurosurg2011，75，1： | 1 |
| 9 | Pelvic exenterations for primary rectal cancer:Analysis from a 10-year national prospective database显示文摘AIM To identify short-term and oncologic outcomes of pelvic exenterations(PE) for locally advanced primary rectal cancer(LAPRC) in patients included in a national prospective database.METHODS Few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Espa?ola de Cirujanos(AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence(LR), disease-free survival(DFS) and overall survival(OS). A propensitymatched comparison with patients who underwent non-exenterative surgery for low rectal cancers was performed as a secondary endpoint.RESULTS Eight-two patients were included. The mean age was 61.8 ± 11.5 years. More than half of the patients experienced at least one complication. Surgical site infections were the most common complication(abdominal wound 18.3%, perineal closure 19.4%). Thirty-three multivisceral resections were performed, including two hepatectomies and four metastasectomies. The long-term outcomes of the 64 patients operated on before 2013 were assessed. The five-year LR was 15.6%, the distant recurrence rate was 21.9%, and OS was 67.2%, with a mean survival of 43.8 mo. R+ve resection increased LR [hazard ratio(HR) = 5.58, 95%CI: 1.04-30.07, P = 0.04]. The quality of the mesorectum was associated with DFS. Perioperative complications were independent predictors of shorter survival(HR = 3.53, 95%CI: 1.12-10.94, P = 0.03). In the propensity-matched analysis, PE was associated with better quality of the specimen and tended to achieve lower LR with similar OS.CONCLUSION PE is an extensive procedure, justified if disease-free margins can be obtained. Further studies should define indications, accreditation policy, and quality of life in LAPRC. | Gianluca Pellino Sebastiano Biondo Antonio Codina Cazador JoséMaría Enríquez-Navascues Eloy Espín-Basany Jose Vicente Roig-Vila Eduardo García-Granero | 2018 | World Journal of Gastroenterology2018，24，45： | 1 |
| 10 | Performance of a multiplex qualitative PCR LCx assay for detection of human immunodeficiency virus type 1 (HIV- 1 ) group M subtypes, group O,and HIV-2显示文摘 | Abravaya K Esping C Hoenle R | 2000 | J Clin Microbiol2000，38，2： | 1 |
| 11 | Initiation of pre-B cell receptor signaling: common and distinctive features in human and mouse 显示文摘 | Espeli M Rossi B Mancini SJ | 2006 | Semin Immunol2006，18，1： | 1 |
| 12 | Microscopic examination of the interface region in 6061-Al/SiC composites reinforced with as-received and oxidized SiC particles显示文摘 | H. Ribes M. Suéry G. L’espérance J. G. Legoux | 1990 | Metallurgical Transactions A1990，，9： | 1 |
| 13 | Sensitivity study of the dynamics of three-phase photovoltaic inverters with an LCL grid filter显示文摘 | Figueres E Esp?n F | | 0，，03： | 1 |
| 14 | Autolngous osteochondral mosaicplasty for the treatment of full hickness defects of weight bearing joints:ten years of experimental and clinical experience显示文摘 | Hangedy L Ful ESP | 2003 | J BoneJoint Surg(Am)2003，85，2： | 1 |
| 15 | The role of inflammation and infection in preterm birth显示文摘 | Romero R Esp inoza J Goncalves LF | 2007 | Semin Reprod Med2007，25，1： | 1 |
| 16 | Assessment of lysine requirement for maximal protein accretion in Atlantic salmon using plant protein diets显示文摘 | ESPE M LEMME A PETRI A | 2007 | Aquaculture2007，263，： | 1 |
| 17 | Nutritional value of stored fish silage as protein source of young rats显示文摘 | ESPE M RAA J NJAA L R | 1989 | Journal of the Science of Food and Agriculture1989，49，3： | 1 |
| 18 | WebTurning:Teleoperation of a CNC turning center through the Internet显示文摘 | Alberto Jose ' A' lvares Joa~o Carlos Esp' ndola Ferreira | 2006 | Journal of Materials Procesing Technology2006，，179： | 1 |
| 19 | Optimization of acoustic response显示文摘 | Tinnsten M Esping B Jonsson M | 1999 | Struct Optin1999，18，1： | 1 |
| 20 | Novel production of Atlantic salmon (Salmo salar) protein based on combined replacement of fish meal and fish oil with plant meal and vegetable oil blends 显示文摘 | Torstensen B E Espe M Sanden M | 2008 | Aquaculture2008，285，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员