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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 3 | Transarterial emboliza- tion for acute head and neck bleeding: eight-year experi- ence with emphasis on rebleeding risk in cancer patients 显示文摘 | Bachar G Esmat N Stern S | 2013 | Laryngoscope2013，123，5： | 1 |
| 4 | GSA: A gravitational search algorithm 显示文摘 | ESMAT R HOSSEIN N SAEID S | 2009 | Information Sciences2009，179，3： | 1 |
| 5 | Kinetics, equilibrium and thermodynamic study of Cr(VI) sorption into toluidine blue o-impregnated XAD-7 resin beads and its application for the treatment of wastewaters containing Cr(VI) 显示文摘 | Ahmad H B Mohammad S H Masoud S G Somayye Z Esmat H Horiyye H B | 2010 | Chemical Engineering Journal2010，160，： | 1 |
| 6 | Bioactive compounds, Antioxidant potential, and Hepatoprotective activity of Sea cucumber (Holothuria atra) against Thioacetamide intoxication in Rats 显示文摘 | Esmat A Y Said A A EI-Masry K S | 2013 | Nutrition2013，29，1： | 1 |
| 7 | BGSA: binary gravitational search algorithm 显示文摘 | ESMAT R HOSSEIN N P SAEID S | 2010 | Natural Computing2010，9，3： | 1 |
| 8 | GSA : a gravitational search algo- rithm 显示文摘 | Esmat R Hossein N Saeid S | 2009 | Information Sciences2009，179，13： | 1 |
| 9 | GSA: A Gravitational Search Algorithm显示文摘 | ESMAT R HOSSEIN N P SAEID S | 2009 | Information Sciences2009，179，13： | 1 |
| 10 | Response and seroconversion rates among HBeAg-positive chronic HBV Egyptian patients trea- ted with peginterferon alpha 2a (Pegasys), a single-centre experi- ence显示文摘 | Maklad S Esmat G Doss W | 2013 | ArabJ Gastroenterol2013，14，2： | 1 |
| 11 | Effects of dietary magnesium and/or manganese variables on the growth rate and metabolism of mice显示文摘 | FAHIM F A MORCOS N Y S ESMAT A Y | 1990 | Annals of Nutrition and Metabolism1990，34，3： | 1 |
| 12 | Assessment of hepatic fibrosis in pediatric cases with hepatitis C virus in Egypt显示文摘AIM: To assess hepatic fibrosis and factors associated with its progression in children with HCV infection. METHODS: At the Hepatology Unit,Cairo University Children's Hospital,a single liver biopsy was performed to 43 children with HCV infection after an informed consent between 1998-2004. Their mean age at liver biopsy was 8.67 ± 4.3 years. RESULTS: Among the 43 patients' biopsies,12 (27.9%) were having no fibrosis,20 (46.5%) mild fibrosis and 11 (25.6%) moderate to severe fibrosis. The median time for development of fibrosis was estimated to be 5.5 years. Developing fibrosis was significantly associated with shorter duration from first detected ALT elevation to biopsy (12 mo vs 1.2 mo,P = 0.015) and having higher levels of direct serum bilirubin (0.3 mg/dL vs 0.5 mg/dL,P = 0.048). No association was found between fibrosis stage and the presence of co-morbid conditions (P = 0.33). CONCLUSION: Hepatic fibrosis was present in 72.1% of children with HCV infection. The development of fibrosis was associated with higher levels of direct serum bilirubin. There was no significant association between fibrosis and age,duration of infection,risk factors,co-morbid conditions and most biochemical parameters. | Manal A El-Hawary Mona S El-Raziky Gamal Esmat Hanan Soliman Amr Abouzied Maissa El-Raziky Wafaa El-Akel Rokaya El-Sayed Fatma Shebl Abdel Aziz Shaheen Hanaa El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，20： | 1 |
| 13 | Suggested mechanisms of ac-tion of UVA phototherapy in morphea : a molecular study 显示文摘 | EI-Mofty M Mostafa W Esmat S | 2004 | Photo-dermatol Photoimmunol Photomed2004，20，： | 1 |
| 14 | Prevalence of Iron deficiency anemia among iranian pregnant women; a systematic review and meta- analysis 显示文摘 | Esmat B Mohammad R Behnam S | 2010 | Journal of reproduction & infertility2010，1，1： | 1 |
| 15 | Quantitative and qualitative evaluation of bio-aerosols in surgery rooms and emergency department of an educational hospital显示文摘 | RAMAZAN M ESMAT S MAZHAR I Q | 2014 | Jundishapur J Microbiol2014，7，11： | 1 |
| 16 | Is a raised CA 19-9 level diagnosticfor a cholangiocarcinoma in patients with no history ofsclerosing cholangitis?显示文摘 | John A R Haghighi K S Taniere P Esmat M E Tan YM BramhalI S R | 2006 | Dig Surg2006，23，56： | 1 |
| 17 | Narrow band Ultraviolet B 311 nm in the treatment of vitiligo: two right-left comparison studies 显示文摘 | El Mofty M Mostafa W Esmat S | 2006 | Photodermatol Photoimmunol Photomed2006，22，： | 1 |
| 18 | GSA: a gravitational search algorithm显示文摘 | Esmat R Hossein N Saeid S | 2009 | Inform Sci2009，179，13： | 1 |
| 19 | GSA: A gravitational searchalgorithm显示文摘 | Esmat R Hossein N Saeid S | 2009 | Information Sciences2009，179，6： | 1 |
| 20 | The Effect of Sesame But- ter- Supplemented Breakfast in Comparison to Common Breakfast on the Severity of Primary Dysmenorrhea in the Students of Ahvaz Jundishapur University of Medical Sci- ences显示文摘 | Esmat S Fatemeh H Majid MS | 2012 | Jundishapur Scientific Medical Journal2012，11，2： | 1 |
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