|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution:A prospective randomized double-blind study显示文摘AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy. | Tarkan Karakan Meltem Ergun Ibrahim Dogan Mehmet Cindoruk Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，19： | 50 |
| 2 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 3 | Combination of allopurinol and hyperbaric oxygen therapy:A new treatment in experimental acute necrotizing pancreatitis?显示文摘瞄准:在试验性的老鼠在生物化学、组织病理学说的变化,氧化压力,和细菌的易位(BT ) 上调查 allopurinol 和高比重的氧(HBO ) 治疗的单个、联合的效果尖锐胰腺炎(AP ) 。方法:85 只 Sprague-Dawley 老鼠在学习被包括。85 只老鼠中的十五个被用作控制(假冒,组我) 。AP 在留下经由管内牛磺胆酸盐注入被导致七十只老鼠。幸存到尖锐引起坏死胰腺炎的正式就职的老鼠被使随机化进四个组。组 II 独自收到了 saline,组 III allopurinol,加 HBO 的组 IV allopurinol 和组 V HBO。浆液淀粉酶层次,氧化压力参数, BT 和组织病理学说的分数是坚定的。结果:浆液淀粉酶层次在与组 II 相比的组 III, IV 和 V 是更低的(974 +/- 110, 384 +/- 40, 851 +/- 56,和 1664 +/- 234 U/L,分别地 P <
0.05,为所有) 。联合揭示的二种处理选择显著地降低 median [25-75 百分位数] 组织病理学说的分数什么时候与单个政府相比(13 [12.5-15 ] 在 allopurinol 组, 9.5 [7-11.75 ] 在 HBO 组,并且 6 [4.5-7.5 ] 在联合的组, P <
0.01 ) 。氧化压力标记在与控制相比的所有处理组显著地更好。进胰和 mes 伤寒淋巴结的细菌的易位在与组 II 相比的组 III , IV 和 V 是更低的(54%,23%,50%对为到胰的易位的100%,并且62%,46%,58%对为到 mes 伤寒淋巴节点的易位的100%,分别地 P <
0.05 为所有)。结论:当在试验性的老鼠 AP 独立管理了时,现在的学习证实 HBO 和 allopurinol 处理的利益。这些处理选择的联合看起来更有效地阻止胰腺的损害参数的前进。 | Bilgin Comert Ahmet Turan Isik Sezai Aydin Ergun Bozoglu Bulent Unal Salih Deveci Nuket Mas Esref Cinar Mehmet Refik Mas | 2007 | World Journal of Gastroenterology2007，13，46： | 4 |
| 4 | 一名无精症和开咬合畸形男性体内的额外标记染色体15显示文摘额外标记染色体15(sSMC[15])是最常见的标记染色体,通常认为如果不包含Prader-Willi/Angelman综合症关键区(Prader-Willi/Angelman syndrome critical region,PWACR),这一标记染色体就无关紧要。较大标记的关键区域的临床意义在几乎所有与标记染色体15相关的报告中都被提及,较小的标记仅与轻微畸形、无精症、习惯性流产相关。然而,这些不包含PWACR的小额外标记染色体15也可能决定某一基因表现型。我们在一个遗传学门诊对一名无精症病人进行畸形检查,根据标准的细胞遗传学方法进行外周血淋巴染色体分析,还对Y染色体微缺失进行了核仁组织区(NOR)连接、C-连接、荧光原位杂交(Fluorescence in situ hybridization,FISH)以及分子学研究。临床评估确定为畸形特征伴有无精症及重度“安氏Ⅱ类1分类开咬合畸形”。分子细胞遗传结果显示有小额外标记染色体15存在,此外,Y染色体微缺失分析显示无精症不是Y染色体微缺失的结果。额外标记染色体15和下颌不规则的症状同时出现在这一病例中,这可能只是巧合,但也可能标明了一个不仅只是无精症的特定表现型,其特征包括不育、颧骨发育不全、下颌不规则、瘢痕瘤形成以及轻微畸形特征。 | Altug Koc Odul Onur Mehmet Ali Ergun E. Ferda Pergin | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 5 | Airborne Pollen Grains Of Afyon, Turkey显示文摘The airborne pollen grains of Afyon have been studied for a two_year period (1999-2000) with a Durham sampler. A total of 14 367 pollen grains belonging to 40 taxa have been identified and recorded with some unidentified ones. Of them, 6 732 were identified in 1999 and 7 635 in 2000. Of the total pollen grains, 69.67% were arboreal, 26.64% non_arboreal and 3.68 % unidentified. The majority of the investigated pollen grains were from Pinus, Gramineae, Cupressaceae, Platanus , Chenopodiaceae/Amaranthaceae, Quercus, Ailanthus, Moraceae, Juglans , Salix, Cedrus and Rosaceae. The highest level of pollen grains was in May. | Adem BICAKCI 1, Süheyla ERGUN 2, Sevcan TATLIDIL 1, Hulusi MALYER 1, Sabri ?ZYURT 2, Ahmet AKKAYA 3, Nihat SAPAN 5 Department of Biology, Faculty of Science, University of Uludag, Bursa, Turkey 2. Department of Biology, Faculty of Science, University of Afyon Kocatepe, Afyon Turkey 3. Department of Pulmonology, Faculty of Medicine, University of Süleyman Demirel, Isparta, Turkey 4. Division of Pediatric Allergy, Faculty of Medicine, University of Uludag, Bursa, Turkey) | 2002 | Acta Botanica Sinica2002，44，11： | 3 |
| 6 | Amifostine enhances the antioxidant and hepatoprotective effects of UW and HTK preservation solutions显示文摘AIM:To investigate whether amifostine contributes to the antioxidant and cytoprotective effects of histidinetryptophan-ketoglutarate(HTK)and University of Wisconsin(UW)preservation solutions.METHODS:Forty-eight Sprague Dawley male ratswere equally divided into six groups:(1)ringer Lactate(RL)group;(2)RL+amifostine(RL+A)group;(3)HTK group;(4)HTK+A group;(5)UW group;and(6)UW+A group.Rats in the RL+A,HTK+A and UW+A groups were administered amifostine intraperitoneally at a dose of 200 mg/kg prior to laparotomy.The RL group was perfused with RL into the portal vein.The RL+A group were perfused with RL into the portal vein after amifostine administration.The HTK group received an HTK perfusion while the HTK+A group received an HTK perfusion after administration of amifostine.The UW group received a perfusion of UW,while the UW+A group received a UW perfusion after amifostine administration.Liver biopsy was performed to investigate histopathological,immunochemical[transferase mediated dUTP nick end labeling(TUNEL),inducible nitric oxide syntetase(iNOS)]and ultrastructural alterations.Biochemical alterations were determined by examining levels of alanine aminotransferase,alkaline phosphatase and nitric oxide in the perfusion fluid.RESULTS:Pathological sinusoidal dilatation and centrilobular hydropic alteration were significantly lower in the groups that received amifostine prior to preservation solution perfusion.Although the best results were obtained in the UW+A group,we did not observe a statistically significant difference between the UW+A and HTK+A groups.iNOS grades were significantly lower in the amifostine groups 12 h after treatment.When the amifostine groups were compared against each other,the iNOS grades obtained from the UW+A and HTK+A groups were similar while the RL+A group had a much poorer score.TUNEL assays demonstrated a lower apoptosis ratio in the amifostine groups than in the non-amifostine groups 12 h after treatment.No statistically significant difference was observed between the UW+A and HTK+A groups for apoptosis.Cellular ultrastructure was best preserved in the UW+A and HTK+A groups.CONCLUSION:Here,we show that preoperative administration of a single dose of amifostine is sufficientto minimize the preservation damage in hepatic cells. | Sami Akbulut Sinasi Sevmis Hamdi Karakayali Nilüfer Bayraktar Muge Unlukaplan Ergun Oksuz Atilla Dagdeviren | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 7 | Effect of ionizing radiation on the pteridine metabolic pathway and evaluation of its cytotoxicity in exposed hospital staff显示文摘 | Ayse Basak Engin Mehmet Ali Ergun Erkan Yurtcu Derya Kan Gonul Sahin | 2005 | Mut.Res.-Genetic Toxicology and Environmental Mutagenesis2005，，1： | 2 |
| 8 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Aslan G?knur Aktay Ender Ergun Erdem Yesilada Fatma Ergun | 2003 | Life Sciences2003，，20： | 2 |
| 9 | Cost of illness among patients with diabetic foot ulcer in Turkey显示文摘AIM To evaluate the annual cost of patients with Wagner grade 3-4-5 diabetic foot ulcer(DFU) from the public payer's perspective in Turkey.METHODS This study was conducted focused on a time frame of one year from the public payer's perspective. Cost-ofillness(COI) methodology, which was developed by the World Health Organization, was used in the generation of cost data. By following a clinical path with the COI method, the main total expenses were reached by multiplying the number of uses of each expense item, the percentage of cases that used them and unit costs. Clinical guidelines and real data specific to Turkey were used in the calculation of the direct costs. Monte Carlo Simulation was used in the study as a sensitivity analysis.RESULTS The following were calculated in DFU treatment from the public payer's perspective: The annual average per patient outpatient costs $579.5(4.1%), imaging test costs $283.2(2.0%), laboratory test costs $284.8(2.0%), annual average per patient cost of intervention, rehabilitation and trainings $2291.7(16.0%), annual average per patient cost of drugs used $2545.8(17.8%)and annual average per patient cost of medical materials used in DFU treatment $735.0(5.1%). The average annual per patient cost for hospital admission is $7357.4(51.5%). The average per patient complication cost for DFU is $210.3(1.5%). The average annual per patient cost of DFU treatment in Turkey is $14287.70. As a result of the sensitivity analysis, the standard deviation of the analysis was $5706.60(n = 5000, mean = $14146.8, 95%CI: $13988.6-$14304.9). CONCLUSION The health expenses per person are $-PPP 1045 in 2014 in Turkey and the average annual per patient cost for DFU is 14-fold of said amount. The total health expense in 2014 in Turkey is $-PPP 80.3 billion and the total DFU cost has a 3% share in the total annual health expenses for Turkey. Hospital costs are the highest component in DFU disease costs. In order to prevent DFU, training of the patients at risk and raising consciousness in patients with diabetes mellitus(DM) will provide benefits in terms of economy. Appropriate and efficient treatment of DM is a health intervention that can prevent complications. | Ergun Oksuz Simten Malhan Bilge Sonmez Rukiye Numanoglu Tekin | 2016 | World Journal of Diabetes2016，7，18： | 2 |
| 10 | Multiuser detection using a genetic algorithm in CDMA communications systems 显示文摘 | Ergun C Hacioglu K | 2000 | IEEE Trans on Commun2000，48，8： | 1 |
| 11 | Oral health is impaired in Behcet's disease and is associated with disease severity显示文摘 | Mumcu G Ergun T Inanc N | 2004 | Rheumatotogy2004，43，8： | 1 |
| 12 | Vascular endothelial growth factor and its receptors in normal human testicular tissue显示文摘 | Kilic N Fiedler W | 1997 | Mol Cell Endocrinol1997，131，1： | 1 |
| 13 | Electrocardiogram signals de-noising using lifting-based discrete wavelet transform显示文摘 | Ergun Ercelebi | 2004 | Computers in Biology and Medicine2004，，34： | 1 |
| 14 | Non-small cell lung cancer staging techniques and endoscopic ultrasound:tissue is still the issue显示文摘 | LeBlanc JK Espada R Ergun G | 2003 | Chest2003，123，5： | 1 |
| 15 | CEA-related cell adhesion molecule 1:a potent angiogenic factor and a major effector of vascular endothelial growth factor显示文摘 | Ergun S Kilic N Ziegeler G | 2000 | Mol Cell2000，5，2： | 1 |
| 16 | Forward-Viewing CMUT Arrays for Medical Imaging显示文摘 | Demirci U Ergun A S Oralkan O | 2004 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2004，51，7： | 1 |
| 17 | Vascular endothelial growthfactor, a possible paracrine growth factor in human acute myeloidleukemia显示文摘 | Fiedler W Graven U Ergun S | 1997 | Blood1997，89，6： | 1 |
| 18 | A Fuzzy Logic Multi-phased Signal Control Model for Isolated Junctions 显示文摘 | Sazi Murat Y Ergun Gedizlioglu | 2005 | Transportation Research: Part C2005，13，1： | 1 |
| 19 | Vascular endothelial growth factor and its receptors in normal human testicular tissue显示文摘 | Ergun S Kilic N Fiedler W | 1997 | Mol Cell Endocrinol1997，131，1： | 1 |
| 20 | Fluid flow through packed columns 显示文摘 | Ergun S | 1952 | Chem Eng Progr1952，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员