|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B virus genotypes and lamivudine resistance mutations in Jordan显示文摘AIM:To investigate and identify prevalent hepatitis B virus(HBV) genotypes and to explore lamivudine-resistant mutations among treated and untreated patients in Jordan.METHODS:A total of 107 cases with chronic hepatitis B were recruited from different medical centers in Jordan.Serological tests were preformed for all cases using a microparticle enzyme immunoassay.HBV Genotyping was performed for 70 cases using Line probe genotyping assay.The YMDD mutations were explored for 20 cases(4 were lamivudine naive) using the INNO-LiPA HBV DR assay.RESULTS:Genotype D was the only detected genotype.A total of 6 YMDD mutations were detected in 5 treated patients(31%) while one mutation was detected in the naive patients.Seventeen percent of cases were positive for HBeAg and had statistically significant higher levels of serum aminotransferases.CONCLUSION:HBV genotype D appears to be the only circulating type in Jordanian patients.The YMDD mutations were detected in 31% of lamivudine-treated cases with similar patterns to those found in the literature.We also found a relatively low prevalence of HBeAg expression among examined cases(17%).Awareness of these serologic,genotypic and resistance patterns might help in the formulation of management plans and for predicting clinical outcomes.Further larger scale studies are needed to confirm our results and to examine possible associations among clinical,serologic,and genetic patterns of HBV infections in Jordan. | Hani A Masaadeh Wail A Hayajneh Enayat A Alqudah | 2008 | World Journal of Gastroenterology2008，14，47： | 10 |
| 2 | 抗菌剂效果和 Zataria multiflora Boiss 的香精油的物理化学的性质显示文摘 <正>Objective:To evaluate the antibacterial effect and physicochemical properties of essential oil of Zataria multiflora Boiss.Methods:Antibacterial activity of essential oil of Zataria multiflora Boiss was assessed by agar disc diffusion and minimal inhibitory concentration(MIC) was tested by E test.Results:The essential oil of Zataria multiflora Boiss was effective on pathogenic bacteria particularly Staphylococcus aureus(S.aureus).The MIC values of the target cultures ranged from 0.39 mg/mL to 1.56 mg/mL.The physicochemical properties like effects of pH, temperature,detergents,and enzymes on the activity of essential oil from Zataria multiflora Boiss were also determined.The essential oil was quite stable to temperature as tested against 5. aureus and Escherichia coli(E.coli).The essential oil was very stable over a wide range of pH. The antibacterial activity of essential oil was insensitive to various protein-denaturing detergents (Such as Tween 80,Tween 20,Triton 100,etc.) and enzymes(namely proteinase K,trypsin, lipase,and lysosyme).Conclusions:A potential use of the essential oil from Zataria multiflora Boiss is suggested.More studies including further purification,mass spectra,nuclear magnetic resonance(NMR) and evaluation of toxicity are needed for confirmation of this suggestion. | Mansour Amin Enayat Kalantar Neda Mohammad-Saeid Behzad Ahsan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 5 |
| 3 | Synthesis of 6-chloro and 6-fluoro-4-hydroxyl-2-quinolone and their azo disperse dyes显示文摘In this study,6-chloro-4-hydroxy-2-quinolone and 6-flouro-4-hydroxy-2-quinolone were synthesized from corresponding dianilides.These compounds were coupled with some diazotized aromatic amines to give the corresponding azo disperse dyes.The structures of the quinolone derivatives and new azo dyes were confirmed by UV-vis,FT-IR,~1H NMR and elemental analysis. | Enayat O'llah Moradi-e-Rufchahi | 2010 | Chinese Chemical Letters2010，21，5： | 2 |
| 4 | Plasma D-dimer level in early and late-onset neonatal sepsis显示文摘BACKGROUND Neonatal sepsis is a life-threatening disease.Early diagnosis is essential,but no single marker of infection has been identified.Sepsis activates a coagulation cascade with simultaneous production of the D-dimers due to lysis of fibrin.Ddimer test reflects the activation of the coagulation system.AIM To assess the D-dimer plasma level,elaborating its clinicopathological value in neonates with early-onset and late-onset neonatal sepsis.METHODS The study was a prospective cross-sectional study that included ninety neonates;divided into three groups:Group I:Early-onset sepsis(EOS);Group II:Late-onset sepsis(LOS);and GroupⅢ:Control group.We diagnosed neonatal sepsis according to our protocol.C-reactive protein(CRP)and D-dimer assays were compared between EOS and LOS and correlated to the causative microbiological agents.RESULTS D-dimer was significantly higher in septic groups with a considerably higher number of cases with positive D-dimer.Neonates with LOS had substantially higher levels of D-dimer than EOS,with no significant differences in CRP.Neonates with LOS had a significantly longer hospitalization duration and higher gram-negative bacteriemia and mortality rates than EOS(P<0.01).Gramnegative bacteria have the highest D-dimer levels(Acinetobacter,Klebsiella,and Pseudomonas)and CRP(Serratia,Klebsiella,and Pseudomonas);while gram-positive sepsis was associated with relatively lower levels.D-dimer had a significant negative correlation with hemoglobin level and platelet count;and a significant positive correlation with CRP,hospitalization duration,and mortality rates.The best-suggested cut-off point for D-dimer in neonatal sepsis was 0.75 mg/L,giving a sensitivity of 72.7%and specificity of 86.7%.The D-dimer assay has specificity and sensitivity comparable to CRP in the current study.CONCLUSION The current study revealed a significant diagnostic value for D-dimer in neonatal sepsis.D-dimer can be used as an adjunct to other sepsis markers to increase the sensitivity and specificity of diagnosing neonatal sepsis. | Mohammed Al-Biltagi Ehab M Hantash Mohammed Ramadan El-Shanshory Enayat Aly Badr Mohamed Zahra Manar Hany Anwar | 2022 | World Journal of Critical Care Medicine2022，11，3： | 2 |
| 5 | Homozygous gene conversion in yon Willebrand factor gene as a cause of type 3 yon Willebrand disease and predisposition to inhibitor development 显示文摘 | Surdhar G K Enayat M S Lawton S | 2001 | Blood2001，98，1： | 1 |
| 6 | Short communication effect of mean stress on fatigue behavior of GFRP pultruded rod composites 显示文摘 | Abd Allah M H Enayat MAbdin Selmy A I | 1997 | Composite:Part1997，28，： | 1 |
| 7 | 查看详情显示文摘 | Forouzanmelu N Karimzadeh F Enayat M H | | 0，，： | 1 |
| 8 | Mushroom insoluble polysaccharides prevent carbon tetrachloride-induced hepatotoxicity in rat显示文摘 | Somaia A. Nada Enayat A. Omara Omar M.E. Abdel-Salam Hanan G. Zahran | 2010 | Food and Chemical Toxicology2010，，11： | 1 |
| 9 | Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain显示文摘Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) activity.The concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(P<0.05) accompanied by an increase in NO by 73.1%(P<0.05) and a decrease in GSH concentration by 29.4%(P<0.05). In addition, brain PON-1 activity significantly decreased by63.0%(P<0.05) and striatal Bcl-2 significantly decreased by 27.9%(P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal vacuolation.Rotenone also caused pronounced expression of iNOS in the cerebral cortex and striatum.Treatment with misoprostol at doses of 100 and 1 000 μg/kg resulted in decreased brain MDA(by 16.5%-23.0%)(P<0.05) and NO levels(by 37.1%-40.7%)(P<0.05) and increased GSH concentrations(by 18.8%-30.1%)(P<0.05). PON-1 activity was significantly increased by80.0%-114.8%(P<0.05) by misoprostol at 100 and 1 000 μg/kg, respectively. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cerebral cortex and striatum of rotenone intoxicated rats. Conclusions: These data suggest that misoprostol prevents the rotenone-induced neurodegeneration in rat brain by reducing brain oxidative stress. | Omar M.E.Abdel-Salam Amany A Sleem Eman R Youness Nadia A Mohammed Enayat A Omara | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，1： | 1 |
| 10 | Homozygous gene conversion in von Willbrand factor gene as a cause of type 3 yon Willbrand disease and predisposition to inhibitor development 显示文摘 | Surdhar GK Enayat MS Lawson S | 2001 | Blood2001，98，： | 1 |
| 11 | Mutations in all five exons of SOD-1 may cause ALS显示文摘 | SHAW CE ENAYAT ZE CHIOZA BA | | 0，，03： | 1 |
| 12 | Heterotrophic ossification in a patient suspected of having osteomyelitis:additional value of SPECT/CT显示文摘 | Ul Hassan F Enayat M Mohammed F | | 0，，02： | 1 |
| 13 | Heterotrophic ossification in a patient suspected of having osteomyelitis:additional value of SPECT/ CT 显示文摘 | Ul HF Enayat M Mohammed F | 2012 | Clin Nucl Med2012，37，2： | 1 |
| 14 | A comparison of the boundary element and superposition methods显示文摘 | Gar Burgess Enayat Mahajerin | 1984 | Computers and Structures1984，19，5： | 1 |
| 15 | Dendritic Cell Dif- ferentiation Induced by a Self-Peptide Derived from Apoli poprotein E1显示文摘 | Tracey AS Enayat N Beverly JR | 2008 | J Immunol2008，181，： | 1 |
| 16 | Dendritic Cell differentiation induced by a self- peptide derived from apolipoprotein EI显示文摘 | TRACEY A STEPHENS ENAYAT NIKOOPOUR BEVERLY J RIDER | 2008 | J Immunol2008，181，： | 1 |
| 17 | Comparative antioxidant activity of extracts from leaves, bark and catkins of Salix aegyptiaca sp 显示文摘 | ENAYAT S & BANERJEE S | 2009 | Food Chemistry2009，116，： | 1 |
| 18 | A novel penetration catheter (Tomus) as bail - out device after balloon failure to recanalise long, old calcified chronic occlusions 显示文摘 | REIFART N ENAYAT D GIOKOGLU K | 2008 | EuroIntervention2008，3，5： | 1 |
| 19 | Comparative antioxidant activity ofextracts from leaves,bark and catkins of alix aegyptiaca sp 显示文摘 | Enayat S Banerjee S | 2009 | Food Chemistry2009，116，： | 1 |
| 20 | Nitric oxide and prostacyclin modulate the alterations in cardiac action potential duration mediated by platelets during ischaemia显示文摘 | Goulielmos NV Enayat ZE Sheridan Dj | 1995 | Cardiovasc Res1995，30，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员