|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo显示文摘由一个金 nanorod 核心和与 hematoporphyrin (HP ) 做的 mesoporous 硅石壳组成的 Nanocomposites (NC ) 被制作了以便由在 vivo 联合 photothermal 和光力学的治疗(太平洋夏季时间 + PTT ) 改进癌症治疗的效率。除了 810830 nm 附近的长波长的电浆子回声,制作 NC 展出了相应的一座 400-nm 吸收度山峰围住 HP,在 632.5-nm Q 乐队附近在 633-nm 刺激下面产生了汗衫氧,并且生产了在 808-nm 下面的热在红外线附近(NIR ) 激光照耀。这些形式被用于联合太平洋夏季时间 + PTT 治疗大(大约 3 cm3 ) 在有一只 xenorafted 肿瘤老鼠的 vivo 的稳固的肿瘤当模特儿。NC 直接被注入肿瘤并且与 633-nm 和 808-nm 激光同时照耀刺激联合光力学并且 NC 的 photothermal 活动。联合治疗的效率被光连贯断层摄影术评估,组织学的分析,并且由肿瘤体积生长的大小在一个 21 天的时期期间。调停 NC 的太平洋夏季时间在组织组织学并且到导致了弱变化一中等在肿瘤体积的 20% 减少。相反,联合太平洋夏季时间 + PTT 处理导致了大区域的肿瘤坏死并且在肿瘤体积导致了戏剧的减少。 | Georgy Terentyuk Elizaveta Panfilova Vitaly Khanadeev Daniil Chumakov Elina Genina Alexey Bashkatov Valery Tuchin Alia Bucharskaya Galina Maslyakova Nikolai Khlebtsov Boris Khlebtsov | 2014 | Nano Research2014，7，3： | 17 |
| 2 | 经济欠发达地区农村产前保健项目对产妇知信行的影响显示文摘为探索农村社区产前保健项目对产妇的孕产期健康与保健相关知识、态度和行为的影响 ,采取整群随机抽样的方法确定要调查的村 ,入户问卷调查干预组 41 1名、对照组 442名产妇。结果表明 ,干预组产妇掌握母婴健康保健知识较好、正确或恰当态度率较高、正确行为率较高。但两组产妇对首次产前检查孕周的正确回答率均在 50 %以下 ,对孕期无异常也要定期产前检查的正确态度率不理想 (干预组 61 %、对照组 45% )。说明产前保健项目在一定程度上改善了产妇的知信行 ,但改善的力度还不够大 。 | 励晓红 吴擢春 kirsi Viisainen Elina Hemminki | 2003 | 中国妇幼保健2003，18，7： | 17 |
| 3 | 经济落后地区农村妇女产次与妊娠结局关系的探讨显示文摘为了解经济落后地区农村妇女产次、妊娠结局现状及关系 ,为提高农村地区妇女生殖健康水平提供信息基础 ,统计分析安徽省定远县 2 0个乡镇计划生育部门日常记录的 36 98名妇女的产次及妊娠结局资料。结果 :计划外怀孕占总怀孕数的 9.30 % ,高胎次及计划外怀孕妇女流产、死产比例偏高。建议 :计划生育部门和妇幼保健部门应当通力合作 ,加强对计划外怀孕、人工流产的管理工作 。 | 王瑛 吴擢春 许海 Kirsi Viisainen Elina Hemminki | 2002 | 中国妇幼保健2002，17，2： | 10 |
| 4 | Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-γ production显示文摘AIM: To investigate the capacity of potentially probiotic strains from six bacterial genera to induce cytokine production alone or in combinations in order to identify potential enhancing or synergistic effects in order to select probiotic bacteria for in vivo purposes. METHODS: Cytokine production in human peripheral blood mononuclear cells (PBMC) in response to stimulation with eleven different potentially probiotic bacterial strains from Streptococcus , Lactobacillus , Bifidobacterium , Lactococcus , Leuconostoc and Propionibacterium genera was analysed. Production and mRNA expression of TNF-α, IL-12, IFN-γ and IL-10 were determined by ELISA and Northern blotting, respectively. RESULTS: All tested bacteria induced TNF-α production. The best inducers of Th1 type cytokines IL-12 and IFN-γ were Streptococcus and Leuconostoc strains. All Bifidobacterium and Propionibacterium strains induced higher IL-10 production than other studied bacteria. Stimulation of PBMC with any bacterial combinations did not result in enhanced cytokine production suggesting that different bacteria whether gram-positive or gram- negative compete with each other during host cell interactions.CONCLUSION: The probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-γ than the probiotic Lactobacillus strains. Bacterial combinations did not result in enhanced cytokine production. | Riina A Kekkonen Elina Kajasto Minja Miettinen Ville Veckman Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，8： | 9 |
| 5 | OPTICAL PROPERTIES OF SKIN,SUBCUTANEOUS,AND MUSCLE TISSUES:A REVIEW显示文摘The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated tissues.In this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is presented.Basic principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined. | ALEXEY N.BASHKATOV ELINA A.GENINA VALERY V.TUCHIN | 2011 | Journal of Innovative Optical Health Sciences2011，4，1： | 8 |
| 6 | Pharmacogenomics of Cisplatin Sensitivity in Non-small Cell Lung Cancer显示文摘Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30 years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer(NSCLC) as the standard of care. However, therapeutic outcomes vary from patient to patient. Considerable efforts have been invested to identify biomarkers that can be used to predict cisplatin sensitivity in NSCLC. Here we reviewed current evidence for cisplatin sensitivity biomarkers in NSCLC. We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways. Current evidence suggests that cisplatin-based treatment could be improved by the use of these biomarkers. | Maimon C.Rose Elina Kostyanovskaya R.Stephanie Huang | 2014 | Genomics, Proteomics & Bioinformatics2014，12，5： | 6 |
| 7 | 经济欠发达地区农村产前保健项目中间结果评价显示文摘目的 :对经济欠发达地区农村开展的产前保健项目的中间结果进行评价。方法 :由县卫生局组织有关产前保健专家对乡镇卫生院产科医务人员进行业务培训 ;由县卫生局和乡镇领导协调卫生与计划生育部门开展农村社区产前保健的健康教育 ;由乡镇卫生院产科助产士负责开展产前检查。应用整群随机分组的设计及做干预前后测量的方法进行评价。评价的指标包括初次产前检查孕周、产前检查次数和产前检查率。结果 :干预使孕妇初次产前检查的时间提前。干预提高了产前检查率。干预提高了高危妊娠妇女的产前检查次数。结论 :卫生与计划生育部门合作开展产前保健是促进经济欠发过地区农村母婴保健工作可行与有效的途径。 | 李晓燕 吴擢春 汪涛 Kirsi Viisainen 张仁贵 许海凤 Elina Hemminki | 2004 | 中国卫生资源2004，7，6： | 6 |
| 8 | Hyperphosphatemia after sodium phosphate laxatives in low risk patients:Prospective study显示文摘AIM:To establish the frequency of hyperphosphate-mia following the administration of sodium phosphate laxatives in low-risk patients. METHODS:One hundred consecutive ASAⅠ-Ⅱindividuals aged 35-74 years,who were undergoing colonic cleansing with oral sodium phosphate(OSP) before colonoscopy were recruited for this prospective study.Exclusion criteria:congestive heart failure, chronic kidney disease,diabetes,liver cirrhosis,intestinal obstruction,decreased bowel motility,increased bowel permeability,and hyperparathyroidism.The day before colonoscopy,all the participants entered a 24-h period of diet that consisted of 4 L of clear fluids with sugar or honey and 90 mL(60 g)of OSP in two 45-mL doses,5 h apart.Serum phosphate was measured before and after the administration of the laxative. RESULTS:The main demographic data(mean±SD) were:age,58.9±8.4 years;height,163.8±8.6 cm; weight,71±13 kg;body mass index,26±4;women, 66%.Serum phosphate increased from 3.74±0.56 to 5.58±1.1 mg/dL,which surpassed the normal value (2.5-4.5 mg/dL)in 87%of the patients.The highest serum phosphate was 9.6 mg/dL.Urea and creatinine remained within normal limits.Post-treatment OSP se-rum phosphate concentration correlated inversely with glomerular filtration rate(P<0.007,R 2=0.0755),total body water(P<0.001,R 2=0.156)and weight(P< 0.013,R 2=0.0635). CONCLUSION:In low-risk,well-hydrated patients, the standard dose of OSP-laxative-induced hyperphos-phatemia is related to body weight. | Marcela Noemi Casais Guillermo Rosa-Diez Susana Pérez Elina Noemi Mansilla Susana Bravo Francisco Carlos Bonofiglio | 2009 | World Journal of Gastroenterology2009，15，47： | 5 |
| 9 | 欠发达地区农村围产儿死亡率及其影响因素显示文摘目的 利用基层计划生育部门登记资料 ,分析欠发达地区农村的围产儿死亡率及其影响因素。方法 利用乡镇计生站提供的妊娠相关资料进行统计分析。结果 死胎死产、早期新生儿死亡和围产儿死亡率分别为2 4‰ ,46‰和 69‰。男女婴早期新生儿死亡率分别为 2 9‰和 69‰。围产儿死亡率与产次及当地经济水平有关。结论 围产儿死亡率高于已报道的同期农村的水平 ,不同产次围产儿死亡率的差异及较高的出生婴儿性别比反映了经济。 | 吴擢春 励晓红 Kirsi Viisainen Elina Hemminli | 2004 | 中国公共卫生2004，20，3： | 4 |
| 10 | Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917显示文摘AIM: To evaluate the effect of oral Escherichia coli(E. coli) Nissle application on the outcome of intestinalborne dermatoses.METHODS: In a randomized, controlled, non-blinded prospective clinical trial 82 patients with intestinal-borne facial dermatoses characterized by an erythematous papular-pustular rash were screened. At the initiation visit 37 patients entered the experimental arm and 20 patients constituted the control arm. All 57 patients were treated with a vegetarian diet and conventional topical therapy of the dermatoses with ointments containing tetracycline, steroids and retinoids. In the experimental arm patients received a one month therapy with oral E. coli Nissle at a maintenance dose of 2 capsules daily. The experimental group was compared to a non-treatment group only receiving the diet and topical therapy. The primary outcome parameter was improvement of the dermatoses, secondary parameters included life quality and adverse events. In addition the immunological reaction profile(Ig A, interleucin-8 and interferon-a) was determined. Furthermore the changes of stool consistency and the microbiota composition over the time of intervention were recorded.RESULTS: Eighty-nine percent of the patients with acne, papular-pustular rosacea and seborrhoic dermatitis responded to E. coli Nissle therapy with significant amelioration or complete recovery in contrastto 56% in the control arm(P < 0.01). Accordingly, in the E. coli Nissle treated patients life quality improved significantly(P < 0.01), and adverse events were not recorded. The clinical improvement was associated with a significant increase of Ig A levels to normal values in serum as well as suppression of the proinflammatory cytokine IL-8(P < 0.01 for both parameters). In the E. coli Nissle treated group a shift towards a protective microbiota with predominance of bifidobacteria and lactobacteria(> 107 CFU/g stool) was observed in 79% and 63% of the patients, respectively(P < 0.01), compared to no change in the control group without E. coli Nissle. Moreover, the detection rate of a pathogenic flora dropped from 73% to 14 % of the patients in the experimental arm(P < 0.01) with no significant change in the control arm(accounting 80% before and 70% after the observation period, P > 0.05). Accordingly, stool consistency, color and smell normalized in the E. coli Nissle treated patients. CONCLUSION: E. coli Nissle protects the mucus barrier by overgrowth of a favorable gut microbiota with less immunoreactive potential which finally leads to clinical improvement of intestinal borne dermatoses. | Elina Manzhalii Daniel Hornuss Wolfgang Stremmel | 2016 | World Journal of Gastroenterology2016，22，23： | 4 |
| 11 | The Role of RNA Structure in Posttranscriptional Regulation of Gene Expression显示文摘当更多的信息在抄写和翻译的机制上被聚集,这些过程高度被调整,正在变得明显。第二等的 mRNA 和第三级的结构的形成是一个如此的规章的过程直到最近,它没深入地被分析。这些 mRNA 结构的形成有潜力提高并且禁止抄本的其他的拼接,并且调整翻译的率和数量。当,这规章的机制潜在地在 transcriptional 和翻译水平影响潜在地也利用非编码的 RNA 的广阔数组,它保证进一步的调查。当前,包括 RNA 结构(同等) 的平行分析的许多高产量的定序技术,定序的破碎(FragSeq ) 和选择 2 氢氧根 acylation 由教材扩展(形状) 分析了在 mRNA 的染色体宽的鉴定和分析带路结构形成。这些新定序技术加亮 transcriptome 的差异和复杂性,并且表明能为新治疗学的途径成为一个目标的另一规章的机制。 | Elina Jacobs James D.Mills Michael Janitz | 2012 | Journal of Genetics and Genomics2012，39，10： | 3 |
| 12 | Chloroplast Proteins without Cleavable Transit Peptides: Rare Exceptions or a Major Constituent of the Chloroplast Proteome?显示文摘大多数叶绿体蛋白质(cp 蛋白质) 是编码原子核的,作为包含 presequence (cTP ) 的先锋蛋白质在 cytosolic 核糖体上综合了,并且 post-translationally 经由进细胞器的 Tic/Toc 建筑群进口了,在 cTP 被移开的地方。仅仅不要求 cTPs (不在经典中的 cp 蛋白质) 的 cp 蛋白质的一些不含糊的例子到目前为止被报导了。然而,从这里介绍的大规模 proteomic 研究的数据的调查建议在全部的 cp proteome 的如此的蛋白质的部分可能象 30% 一样大。探索这差异,我们选择了一个代表 28 通常认为的不在经典中的 cp 蛋白质设定,并且在 vitro 进口和红使用了荧光灯决定他们的亚 cellular 目的地的蛋白质(RFP ) 熔化试金。四蛋白质包括胚胎有缺陷者 1211, glycolate oxidase 2,蛋白质二硫化物象 isomerase 一样蛋白质(PDII ) ,和通常认为的谷胱甘肽 S-transferase,能明白地被分到叶绿体。几其它(潜在的 cp 蛋白质) 被发现在 vitro 被进口进叶绿体,但是当 RFP 被熔化到他们的 C 终端目的时,没能本地化到细胞器。推测建议进入的 cp 蛋白质的部分尽管他们缺乏 cTP,细胞器的内部分隔空间可能象 11.4% 全部的 cp proteome 一样大。我们的数据也支持把外部膜力量与 cp 联系的 cytosolic 蛋白质说明在更早的研究获得的假积极 cp 蛋白质的想法。 | Ute Armbruster Alexander Hertle Elina Makarenko Jessica Zuhlke Mathias Pribil Angela Dietzmann Ivo Schliebner Elena Aseeva Elena Fenino Michael Scharfenberg Christian Voigt Dario Leister | 2009 | Molecular Plant2009，2，6： | 3 |
| 13 | Case report of Graves' disease manifesting with odynophagia and heartburn显示文摘Graves' disease is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes like ophthalmopathy, pretibial myxedema(dermopathy), acropathy, cardiomyopathy, and encephalopathy. Though quite rare, this disease can also manifest with gastrointestinal symptoms such as dysphagia, heartburn, nausea, vomiting and diarrhea. We report a clinical case of Graves' disease manifesting with dysfunction of the esophagus and heartburn in a 61-year-old man. In the muscular layer of the esophagus we found dystrophic changes led to its atony, which was documented by endoscopy and high-resolution manometry. The pathology features of esophageal symptoms were: focal proliferation of the basal cells, vascular distension, and dystrophy of the epithelial cells. Antithyroid treatment led to decrease of all clinical symptoms after 5 d of Thiamazole administration. Complete restoration of peristalsis in the esophagus, according to manometry, was observed in 1 mo after initiation of treatment. | Yulia Evsyutina Alexander Trukhmanov Vladimir Ivashkin Olga Storonova Elina Godjello | 2015 | World Journal of Gastroenterology2015，21，48： | 3 |
| 14 | Deep‐learning powered whispering gallery mode sensor based on multiplexed imaging at fixed frequency显示文摘During the last decades the whispering gallery mode based sensors have become a prominent solution for label-free sensing of various physical and chemical parameters.At the same time,the widespread utilization of the approach is hindered by the restricted applicability of the known configurations for ambient variations quantification outside the laboratory conditions and their low affordability,where necessity on the spectrally-resolved data collection is among the main limiting factors.In this paper we demonstrate the first realization of an affordable whispering gallery mode sensor powered by deep learning and multi-resonator imaging at a fixed frequency.It has been shown that the approach enables refractive index unit(RIU)prediction with an absolute error at 3×10^(-6) level for dynamic range of the RIU variations from 0 to 2×10^(-3) with temporal resolution of several milliseconds and instrument-driven detection limit of 3×10−5.High sensing accuracy together with instrumental affordability and production simplicity places the reported detector among the most cost-effective realizations of the whispering gallery mode approach.The proposed solution is expected to have a great impact on the shift of the whole sensing paradigm away from the model-based and to the flexible self-learning solutions. | Anton V.Saetchnikov Elina A.Tcherniavskaia Vladimir A.Saetchnikov Andreas Ostendorf | 2020 | Opto-Electronic Advances2020，3，11： | 2 |
| 15 | 全球经济失衡展望——依实证和专题研究的视角显示文摘本文证实了自金融危机爆发以来全球经常账户失衡程度的显著改善。具体来说,美国的经常账户赤字占GDP的比例从6%的高位下降了一半,到了3%;中国的经常账户盈余也有了显著下降。对上述两国失衡的降低,以及更具一般性的全球失衡程度的降低,我们接着考量了其仅仅是由于失衡被金融危机所打断而引起的暂时性偏移,还是长期性的调整。 | Nathan Sheets Elina Ribakova Robert A Sockin | 2012 | 金融发展评论2012，，5： | 2 |
| 16 | Mechanically–biologically treated municipal solid waste as a support medium for microbial methane oxidation to mitigate landfill greenhouse emissions显示文摘 | Juha-Kalle M. Einola A. Elina Karhu Jukka A. Rintala | 2007 | Waste Management2007，，1： | 2 |
| 17 | Successful anti-hepatitis C virus therapy with telaprevir in an HIV/hepatitis C virus co-infected patient with a severe recurrence of hepatitis C virus infection on the liver graft显示文摘 | Teresa M. Antonini Valerie Furlan Elina Teicher Stephanie Haim-Boukobza Mylene Sebagh Audrey Coilly Laurence Bonhomme-Faivre Gilles Peytavin Anne-Marie Roque-Afonso Daniel Vittecoq Didier Samuel Anne-Marie Taburet Jean-Charles Duclos-Vallée | 2013 | AIDS2013，，16： | 2 |
| 18 | Realtime rendering of 3D clouds显示文摘 | Elinas P Sturzlinger W | 2001 | Journal of Graphics Tools2001，5，4： | 2 |
| 19 | Viral pneumonia显示文摘 | Olli Ruuskanen Elina Lahti Lance C Jennings David R Murdoch | 2011 | 2011 (9773)2011，，9773： | 2 |
| 20 | Efficacy of Qigong for the treatment of alopecia universalis: a clinical case report显示文摘Qigong is a part of traditional Chinese medicine. According to the antique treaties, the foundations of traditional Chinese medicine are based in maintaining the harmony between Qi (energy), Jing (essence) and Shen (spirit). Alterations in this harmony can develop and determine the appearance of disease. Therapeutic effects of Qigong are helpful in the prevention and treatment of several diseases. It's main role in restoring body functions is due to the communication between internal organs, tissues and cells. The main goal of this work is to show the efficacy of Qigong in the treatment of a dermatological disease characterized by the appearance of circular or oval patches of missing hair, known as alopecia universalis. For western medicine the exact cause of this illness is not totally revealed, however, it's attributed to psycological, genetics and metabolic alterations. From the traditional Chinese medicine perspective, hair alterations are framed in the area of the water energy, represented by the kidney organ. The results of Qigong treatment suggested that the cranial hair follicles had been activated since the first treatment. As treatment progressed, the cranial hair follicles continued to grow, what's more, the brightness and pigmentation of the hair also increased. Therefore, in the clinical conditions evaluated, Qigong could be an effective alternative treatment in consideration of the visible evidence about rapid and long lasting results. Besides, we did not observe any side effects of Qigong in this case. | Gómez Jensen Alberto Alejandro Martínez Diana Elina Wan Qing Guo | 2019 | Life Research2019，2，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员