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| 1 | Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo显示文摘由一个金 nanorod 核心和与 hematoporphyrin (HP ) 做的 mesoporous 硅石壳组成的 Nanocomposites (NC ) 被制作了以便由在 vivo 联合 photothermal 和光力学的治疗(太平洋夏季时间 + PTT ) 改进癌症治疗的效率。除了 810830 nm 附近的长波长的电浆子回声,制作 NC 展出了相应的一座 400-nm 吸收度山峰围住 HP,在 632.5-nm Q 乐队附近在 633-nm 刺激下面产生了汗衫氧,并且生产了在 808-nm 下面的热在红外线附近(NIR ) 激光照耀。这些形式被用于联合太平洋夏季时间 + PTT 治疗大(大约 3 cm3 ) 在有一只 xenorafted 肿瘤老鼠的 vivo 的稳固的肿瘤当模特儿。NC 直接被注入肿瘤并且与 633-nm 和 808-nm 激光同时照耀刺激联合光力学并且 NC 的 photothermal 活动。联合治疗的效率被光连贯断层摄影术评估,组织学的分析,并且由肿瘤体积生长的大小在一个 21 天的时期期间。调停 NC 的太平洋夏季时间在组织组织学并且到导致了弱变化一中等在肿瘤体积的 20% 减少。相反,联合太平洋夏季时间 + PTT 处理导致了大区域的肿瘤坏死并且在肿瘤体积导致了戏剧的减少。 | Georgy Terentyuk Elizaveta Panfilova Vitaly Khanadeev Daniil Chumakov Elina Genina Alexey Bashkatov Valery Tuchin Alia Bucharskaya Galina Maslyakova Nikolai Khlebtsov Boris Khlebtsov | 2014 | Nano Research2014，7，3： | 17 |
| 2 | Surface-enhanced Raman scattering inside Au@Ag core/shell nanorods显示文摘有在他们内嵌入的 Raman 活跃的分子的 plasmonic nanoparticles 的设计和合成具有为察觉到和成像应用程序的重要兴趣。然而,有可控制的形状,尺寸,和 plasmonic 性质的如此的 nanostructures 的直接合成仍然保持极其挑战性。这里,我们在厚度与 1 ~ 25 nm 的可控制的 Ag 壳在一致 Au@Ag 核心 / 壳 nanorods 的准备报导。1,4-Aminothiophenol (4-ATP ) 分子,用作拉曼记者,在 Au 核心和 Ag 壳之间被定位。在核心 / 壳 nanoparticles 内的记者分子的成功的嵌入被氨基的组的选择氧化的缺席证实,由拉曼光谱学测量了。在里面并且在 nanorods 外面的记者分子的地点上的拉曼紧张的依赖被学习。在内部的分子给强壮、一致的拉曼看了紧张,至少比 nanoparticle 表面上的分子的高的一个数量级。与平常的 surface-functionalized 拉曼标签相对照,聚集并且与嵌入的分子 nanoparticles 聚类减少了散布的提高表面的拉曼(重量的单位) 信号。从这研究的调查结果为在核心 / 壳金属 nanostructures 内利用分子的高重量的单位反应的低 analyte 集中的一种新奇察觉技术提供基础。作为一个例子,我们显示出在答案象 10 9 M 一样低的 thiram 杀真菌剂的柔韧的重量的单位察觉。 | Boris Khlebtsov | 2016 | Nano Research2016，9，8： | 5 |
| 3 | SERS-based lateral flow immunoassay of troponin I by using gapenhanced Raman tags显示文摘The lateral flow immuno assay (LFIA) has emerged as a powerful tool for rapid scree ning owing to its simplicity and flexibility for detection of various biomarkers. However, conventional LFIA strips have several disadvantages, including limits in quantitative analysis and low sensitivity. Here we developed a novel surface-e nhanced Rama n scatteri ng LFIA based on non spherical gap-e nhanced Raman tags (GERTs), with Raman molecules (RMs) embedded in a 1-nm gap between Au nanorod core and Au shell. Such tags have a strong and uniform surface-enhanced Rama n scattering (SERS) resp on se, an order of mag nitude higher than that of other comm on SERS tags such as Au nano rods, nano stars, Au nano shells with surface-adsorbed RMs, or spherical GERTs with embedded RMs. The feasibility of the tags was dem on strated by the semiqua ntitative and sen sitive detecti on of the heart disease biomarker cardiac tropo nin I (cTnI). GERTs were conjugated with mono clonal antibodies and used for LFIA in the same way as ordinary functionalized colloidal gold. The presenee of the target antigen, cTnI, was identified by Raman microscopy mapping of the test zone. With the SERS-based LFIA, the limit of cTnI detection was about 0.1 ng/mL. This value is within the diagnostic range of cTnI in the blood serum of patients with heart infarction and is 30 times lower than that of the colorimetric LFIA test using the same antibodies and either GERTs or colloidal gold as labels. | Boris N. Khlebtsov Daniil N. Bratashov Nadezhda A. Byzova Boris B. Dzantiev Nikolai G. Khlebtsov | 2019 | Nano Research2019，12，2： | 1 |
| 4 | Gold nanoparticles in bio- medical applications: Recent advances and perspectives显示文摘 | Dykman Lev Khlebtsov Nikolai | 2012 | Chem Soc Rev2012，41，6： | 1 |
| 5 | Comprehensive T-matrix reference database: A 2009- 2011 update显示文摘 | Zakharova Nadezhda T Videen Gorden Khlebtsov Nikolai G | 2012 | Journal of Quantitative Spectroscopy and Radiative Transfer2012，113，14： | 1 |
| 6 | Gold nanoparticles in biomedical applications:recent advances and perspectives显示文摘 | Lev Dykman Nikolai Khlebtsov | | 0，，： | 1 |
| 7 | Au-nanocluster-loaded human serum albumin nanoparticles with enhanced cellular uptake for fluorescent imaging显示文摘Protein-directed fluorescent Au nanoclusters have been widely studied owing to their potential applications in sensing,imaging,and drug and gene delivery.However,the use of nanoclusters in drug delivery is limited by low cellular uptake.In this study,human serum albumin-directed Au nanoclusters served as building blocks to obtain protein nanoparticles by desolvation.The nanoparticles had a decent quantum yield(QY),high colloidal stability and low cytotoxicity,and they could be readily conjugated with biological molecules.The cellular uptake of the Au nanoclusters and nanocluster-loaded protein nanoparticles were studied by confocal fluorescence microscopy.Agglomeration of the protein-directed Au nanoclusters into 50–150-nm nanoparticles dramatically increased the cellular uptake. | Boris Khlebtsov Artur Prilepskii Maria Lomova Nikolai Khlebtsov | 2016 | Journal of Innovative Optical Health Sciences2016，9，2： | 0 |
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