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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Subgenomic RNA7 is transcribed with different leader-body junction sites in PRRSV (strain VR2332) infection of CL2621 cells显示文摘 | Faaberg K S Elam M R Nelsen C J | 1998 | Adv Exp Med Biol1998，440，： | 1 |
| 4 | Surface loss in ozone-based atomic layer depositionprocesses 显示文摘 | KNOOPS H C M ELAM J W LIBERA J A | 2011 | Chemistry of Materials2011，23，23： | 1 |
| 5 | Invasive si-nonasal disease due to dematiaceous fungi in immuno-compromised individuals : case report and review ofthe literature显示文摘 | DERBER C ELAM K BEARMAN G | 2010 | Int J Infect Dis2010，143，： | 1 |
| 6 | Population genetic consequences of population size:implications for plant conservation显示文摘 | Ellstrand N C Elam D R | 1993 | Annual Review of Ecology and Systematic1993，24，： | 1 |
| 7 | The Distortion of an Aluminum Crystal During a Tensile Test 显示文摘 | Taylor G I Elam C F | 1923 | Proceedings of the Royal Society1923，102，719： | 1 |
| 8 | 显示文摘 | Elam C C Padro C E G Sandrock G | 2003 | Int J Hydrogen Energy2003，28，： | 1 |
| 9 | Population genetic consequences of small population size :implications for plant conservation 显示文摘 | Ellstrand N C Elam D R | 1993 | Annual review of Ecology and Systematics1993，24，： | 1 |
| 10 | The Plastic Extension and Fracture of Aluminum Crystals 显示文摘 | Taylor G I Elam C F | 1925 | Proceedings of the Royal Society1925，108，745： | 1 |
| 11 | Medical Education Research at the University of Kentucky College of Medicine显示文摘 | Elam C L | 2004 | Academic Medicine2004，79，10： | 1 |
| 12 | Population Genetic Consequences of Small Population Size:Implications for Plant Conservation显示文摘 | Ellstrand N C Elam D R | 1993 | Annual Review of Ecology and Systematics1993，24，： | 1 |
| 13 | RASSF2 is a novel K-Ras-speeifie effeetor and potential tumor suppressor 显示文摘 | VOS M D ELLIS C A ELAM C | 2003 | J Biol Chem2003，278，28： | 1 |
| 14 | Population genetic consequences of small population size: implications for plant conservation显示文摘 | ELLSTRAND N C ELAM D R | 1993 | Annual Review of Ecological Systems1993，24，： | 1 |
| 15 | Population genetic consequences of small population size: implications for plant conservation 显示文摘 | Ellstrand N C Elam D R | 1993 | Ann Rev Ecol Syst1993，24，： | 1 |
| 16 | Pregnancy - related mortality surveillance - United States, 1991 - 1999 显示文摘 | Chang J Elam - Evans LD Berg C J | 2003 | MMWR Surveill Summ2003，52，2： | 1 |
| 17 | Population genetic consequences of small population size: Implications for plant conservation 显示文摘 | ELLSTRAND N C ELAM D R | 1993 | Annual Review of Ecology and Systematics1993，24，： | 1 |
| 18 | Bone grail substitutes显示文摘 | Laurencin C Khan Y Elam SF | 2006 | Expert Rev Med Devies2006，3，1： | 1 |
| 19 | Atomic layer deposition for the conformal coating of nanoporous materials显示文摘 | Elam J W Xiong G Han C Y | | 0，，： | 1 |
| 20 | Exoge-nous interferon- y enhances atherosclerosis in apolipoproteinE^- mice显示文摘 | WHITMAN S C RAVISANKAR P ELAM H | 2000 | Am J Pathol2000，157，6： | 1 |
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