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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Surface loss in ozone-based atomic layer depositionprocesses 显示文摘 | KNOOPS H C M ELAM J W LIBERA J A | 2011 | Chemistry of Materials2011，23，23： | 1 |
| 3 | Sympathetic muscle nerve activity, peripheral blood flows, and baroreceptor reflexes in humans during propofol an- esthesia and surgery显示文摘 | Sellgren J Ejnell H Elam M | 1994 | Anesthesiology1994，80，3： | 1 |
| 4 | Biophysics of actin filament severing by cofilin 显示文摘 | Elam WA Kang H De la Cruz EM | 2013 | FEBS Lett2013，587，8： | 1 |
| 5 | Brain monoamine metabolism is altered in rats following spontaneous,long-distance running显示文摘 | ELAM M SVENSSON T H THOREN P | 1987 | Acta Physiol Scand1987，130，12： | 1 |
| 6 | Exoge-nous interferon- y enhances atherosclerosis in apolipoproteinE^- mice显示文摘 | WHITMAN S C RAVISANKAR P ELAM H | 2000 | Am J Pathol2000，157，6： | 1 |
| 7 | The electrochemical behavior of polysulfides in tetrahydrofuran显示文摘 | Yamin H Penciner J Gorenshtain A Elam M Peled E | 1985 | Journal of Power Sources1985，14，13： | 1 |
| 8 | Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/-mice显示文摘 | Whitman SC Ravisankar P Elam H | 2000 | American Journal of Pathology2000，157，6： | 1 |
| 9 | Exogenous interferon-gammaenhances atherosclerosis in apolipoprotein E-/mice 显示文摘 | Witman SC Ravisankar P Elam H | 2000 | Am J Path2000，157，6： | 1 |
| 10 | Electrical characterization of thin Al2O3 films grown by atomic layer deposition on silicon and various metal substrates 显示文摘 | Groner M D Elam J W Fabreguette F H | 2002 | Thin Solid Films2002，413，1： | 1 |
| 11 | Effects of combina- tion lipid therapy in type 2 diabetes mellitus 显示文摘 | ACCORD G GINSBERG H ELAM M | 2010 | N Engl J Med2010，362，17： | 1 |
| 12 | Exogenous interferon-enhances atherosclerosis in apolipoprotein E-/-mice显示文摘 | Ravisankar P Elam H | 2000 | Am J Pathol2000，157，： | 1 |
| 13 | Sympathetic musclenere activity, peripheral blood flows, and barorecep torreflexes in humans during propofol anesthesia and surgery 显示文摘 | Sellgren J Ejnell H Elam M | 1994 | Anesthesiology1994，80，3： | 1 |
| 14 | Quartz crystal microbalance study of tungsten atomic layer deposition using WF6 and Si2H6 显示文摘 | FABREGUETTE F H SECHRIST Z A ELAM J W | 2005 | Thin Solid Films2005，488，12： | 1 |
| 15 | Exogenous in- terferon-gamma enhances atherosclerosis in apolipopro- rein E-/-mice显示文摘 | Whitman SC Ravisankar P Elam H | 2000 | Am J Pathol2000，157，6： | 1 |
| 16 | Low- temperature A1203 atomic layer deposition显示文摘 | GRONER M D FABREQUETTE F H ELAM J W | 2004 | Chem Mater2004，16，： | 1 |
| 17 | Sympathetic muscle nerve activity, peripheral blood flows, and baroreceptor reflexes in humans during progofol anesthesia and surgery显示文摘 | Sellgren J Ejnell H Elam M | 1994 | Anesthesiology1994，80，53： | 1 |
| 18 | Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein ES/S mice 显示文摘 | Whitman SC Ravisankar P Elam H | 2000 | Am J Pathol2000，157，6： | 1 |
| 19 | Sympathetic muscle nerve activity,peripheral blood flows,and baroreceptor reflexes in human during propofol anesthesia and surgery显示文摘 | Sellgren J Ejnell H Elam M | 1994 | Anaesthesiology1994，80，： | 1 |
| 20 | Sympathetic muscle never activity, peripheral blood flows, and baroreceptor reflexer in humans cluring propofol anesthesia and surgery 显示文摘 | 16,Sellgren J Ejnell H Elam M | 1994 | Anesthesiology,1994;80:534-441994，80，： | 1 |
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