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| 1 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 2 | Advances in local ablation of malignant liver lesions显示文摘Local ablation of liver tumors matured during the recent years and is now proven to be an effective tool in the treatment of malignant liver lesions. Advances focus on the improvement of local tumor control by technical innovations, individual selection of imaging modalities, more accurate needle placement and the free choice of access to the liver. Considering data found in the current literature for conventional local ablative treatment strategies, virtually no single technology is able to demonstrate an unequivocal superiority. Hints at better performance of microwave compared to radiofrequency ablation regarding local tumor control, duration of the procedure and potentially achievable larger size of ablation areas favour the comparably more recent treatment modality; image fusion enables more patients to undergo ultrasound guided local ablation; magnetic resonance guidance may improve primary success rates in selected patients; navigation and robotics accelerate the needle placement and reduces deviation of needle positions; laparoscopic thermoablation results in larger ablation areas and therefore hypothetically better local tumor control under acceptable complication rates, but seems to be limited to patients with no, mild or moderate adhesions following earlier surgical procedures. Apart from that, most techniques appear technically feasible, albeit demanding. Which technology will in the long run become accepted, is subject to future work. | Robert M Eisele | 2016 | World Journal of Gastroenterology2016，22，15： | 7 |
| 3 | 全科医生对心力衰竭患者抑郁状况认知情况的影响因素:一项社区观察性RECODE-心力衰竭研究显示文摘背景相对于其他患者来说,心力衰竭患者更容易患抑郁。但是由于抑郁和心力衰竭这两种疾病有些症状相似,诊断心力衰竭患者是否患抑郁比较困难。本研究旨在调查作为心力衰竭患者的首诊医生,全科医生对心力衰竭患者抑郁状况认知情况及其影响因素。方法此项横断面观察性研究的研究对象为3 224例社区心力衰竭患者。使用医院焦虑抑郁量表、PHQ-9抑郁症筛查量表及PROMIS焦虑抑郁量表中的部分条目调查心力衰竭患者的抑郁状况并对结果进行评估计算。对为这些患者接诊的272例全科医生就患者的躯体和心理共病情况进行了电话采访。使用描述性统计方法分析全科医生对患者的抑郁状况认知情况。使用Logistic回归分析影响全科医生对患者抑郁状况认知情况的因素。结果全科医生仅能诊断出35%的患者患有抑郁。影响其对心力衰竭患者抑郁状况认知情况的因素有:患者文化水平较高,全科医生了解到患者曾患有抑郁,调查前6个月内患者因为情感压力就诊,调查前6个月内患者多次联系全科医生,经纽约心脏病协会(NYHA)分级标准评估的重度心力衰竭,以及较为严重的抑郁症状。全科医生是否学过心理学或精神病学与其对心力衰竭患者抑郁状况的认知情况无关。结论研究表明,全科医生对心力衰竭患者的抑郁状况的认知水平较低。其受到多种因素的影响,包括对认知的定义以及社区临床实践情况。鼓励患者谈其情感压力,花足够的时间去诊疗患者,包括了解其抑郁病史,以及特别用心诊疗文化水平低的患者均可以提升全科医生对心力衰竭患者抑郁状况的认知水平。然而,相对于精神病学诊断标准,全科医生诊断出心力衰竭患者患有抑郁对患者预后及其生活质量的影响有待于进一步调查。 | EISELE M RAKEBRANDT A BOCZOR S 本刊编辑部 | 2017 | 中国全科医学2017，20，20： | 5 |
| 4 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet2010，，9730： | 3 |
| 5 | Global, regional, and national causes of child mortality in 2008: a systematic analysis显示文摘 | Robert E Black Simon Cousens Hope L Johnson Joy E Lawn Igor Rudan Diego G Bassani Prabhat Jha Harry Campbell Christa Fischer Walker Richard Cibulskis Thomas Eisele Li Liu Colin Mathers | 2010 | The Lancet . 2010 (9730)2010，，： | 2 |
| 6 | Long-term results in transsphenoid al approach to sellar and parasellar lesions显示文摘 | Janas JD | 1986 | Laryngoscope1986，98，： | 1 |
| 7 | Differential expression of drugresistance - related genes between sensitive and resistant blasts in acute myeloid leukemia 显示文摘 | Eisele L Klein-Hitpass L Chatzimanolis N | 2007 | Acta Haematol2007，117，1： | 1 |
| 8 | A detailed experimental in- vestigation of impact ionization in n-channel metal-oxide- semiconductor field-effect-transistors at very low drain volt- ages 显示文摘 | Anil K G Mahapatra S Eisele I | 2003 | Solid State Electronics2003，47，6： | 1 |
| 9 | Redefining the viral reservoirs that prevent HIV-1 eradication显示文摘 | Eisele E Siliciano RF | 2012 | Immunity2012，37，3： | 1 |
| 10 | PKD is recru- ited to sites of actin remodelling at the leading edge and negatively regulates cell migration 显示文摘 | EISELER T SCHMID M A TOPBAS F | 2007 | FEBS Lett2007，581，22： | 1 |
| 11 | Isocyanate-free cu- ring of glycidyl azide polymer ( GAP ) with bis-propargyl- succinate( lI ) 显示文摘 | Keicher T Kuglstatter W Eisele S | 2009 | Propellants Explosives Pyrotechnics2009，34，3： | 1 |
| 12 | Kinetics of photocrosslinking reactions of a DCPA/EA matrix in the presence of thiols and acrylates显示文摘 | Eisele G Fouassier J P Reeb R | 1997 | J Polym Sci Part A:Polym Chem1997，35，： | 1 |
| 13 | ITS data archiving: statistical techniques for determining optimal aggregation widths for inductance loop detectors 显示文摘 | Gajewski B J Turner S M Eisele W L | 2000 | Transportation Research Record2000，1719，： | 1 |
| 14 | Etiologic factors in sialolithiasis显示文摘 | Huoh KC Eisele DW | 2011 | Otolaryngol Head Neck Surg2011，145，6： | 1 |
| 15 | A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy显示文摘 | Spivak AM Andrade A Eisele E | 2014 | Clin Infect Dis2014，58，6： | 1 |
| 16 | Reverse column flotation of iron ore显示文摘 | Eisele T C Kawatra K S | 2007 | Minerals & Metallurgical Processing2007，24，1： | 1 |
| 17 | Heat sink application of extruded metal honeycomb materials 显示文摘 | Dempsey B M Eisele S McDowell D L | 2005 | International Journal of Heat and Mass Transfer2005，48，34： | 1 |
| 18 | Esthesioneurob-lastoma: the Johns Hopkins experience 显示文摘 | Resto VA Eisele DW Forastiere A | 2000 | Head Neck2000，22，6： | 1 |
| 19 | Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay显示文摘 | Laird GM Eisele EE Rabi S A | 2013 | PLoS Pathog2013，9，10： | 1 |
| 20 | Measurement and molecular modeling of rolling resistance in tire treads显示文摘 | Wrana C Eisele U Kelbch S | 2000 | Kautschuk und Gummi Kunststoffe2000，53，3： | 1 |
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