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| 1 | Endoscopic diagnosis for colorectal sessile serrated lesions显示文摘BACKGROUND Hyperplastic polyps are considered non-neoplastic, whereas sessile serrated lesions(SSLs) are precursors of cancer via the ‘‘serrated neoplastic pathway’’. The clinical features of SSLs are tumor size(> 5 mm), location in the proximal colon, coverage with abundant mucus called the ‘‘mucus cap’’, indistinct borders, and a cloud-like surface. The features in magnifying narrow-band imaging are varicose microvascular vessels and expanded crypt openings. However, accurate diagnosis is often difficult.AIM To develop a diagnostic score system for SSLs.METHODS We retrospectively reviewed consecutive patients who underwent endoscopic resection during colonoscopy at the Toyoshima endoscopy clinic. We collected data on serrated polyps diagnosed by endoscopic or pathological examination. The significant factors for the diagnosis of SSLs were assessed using logistic regression analysis. Each item that was significant in multivariate analysis was assigned 1 point, with the sum of these points defined as the endoscopic SSL diagnosis score. The optimal cut-off value of the endoscopic SSL diagnosis score was determined by receiver-operating characteristic curve analysis.RESULTS Among 1288 polyps that were endoscopically removed, we analyzed 232 diagnosed as serrated polyps by endoscopic or pathological examination. In the univariate analysis, the location(proximal colon), size(> 5 mm), mucus cap, indistinct borders, cloud-like surface, and varicose microvascular vessels were significantly associated with the diagnosis of SSLs. In the multivariate analysis, size(> 5 mm;P = 0.033), mucus cap(P = 0.005), and indistinct borders(P = 0.033) were independently associated with the diagnosis of SSLs. Size > 5 mm, mucus cap, and indistinct borders were assigned 1 point each and the sum of these points was defined as the endoscopic SSL diagnosis score. The receiver-operating characteristic curve analysis showed an optimal cut-off score of 3, which predicted pathological SSLs with 75% sensitivity, 80% specificity, and 78.4% accuracy. The pathological SSL rate for an endoscopic SSL diagnosis score of 3 was significantly higher than that for an endoscopic SSL diagnosis score of 0, 1, or 2(P < 0.001).CONCLUSION Size > 5 mm, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs. Serrated polyps with these three features should be removed during colonoscopy. | Toshihiro Nishizawa Shuntaro Yoshida Akira Toyoshima Tomoharu Yamada Yoshiki Sakaguchi Taiga Irako Hirotoshi Ebinuma Takanori Kanai Kazuhiko Koike Osamu Toyoshima | 2021 | World Journal of Gastroenterology2021，27，13： | 7 |
| 2 | Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study显示文摘 | Ioan Sporea Simona Bota Markus Peck-Radosavljevic Roxana Sirli Hironori Tanaka Hiroko Iijima Radu Badea Monica Lupsor Carmen Fierbinteanu-Braticevici Ana Petrisor Hidetsugu Saito Hirotoshi Ebinuma Mireen Friedrich-Rust Christoph Sarrazin Hirokazu Takahash | 2012 | European Journal of Radiology2012，，12： | 3 |
| 3 | A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells显示文摘 | Toshiaki Teratani Kengo Tomita Takahiro Suzuki Tetsuya Oshikawa Hirokazu Yokoyama Katsuyoshi Shimamura Susumu Tominaga Sadayuki Hiroi Rie Irie Yoshikiyo Okada Chie Kurihara Hirotoshi Ebinuma Hidetsugu Saito Ryota Hokari Kazuo Sugiyama Takanori Kanai Soich | 2012 | Gastroenterology2012，，1： | 2 |
| 4 | Measurements of physical properties of gas hydrates and in situ observations of formation and decomposition processes via Raman spectroscopy and X-ray diffraction 显示文摘 | Uchida T Takeya S Wilson L D Tulk C A Ripmeester J A Nagao J Ebinuma T Narita l-I | 2003 | Canadian Journal of Physics2003，81，12： | 1 |
| 5 | Dissociation condition measurements of methane hydrate in confined small pores of porous glass显示文摘 | Uchida T Ebinuma T Ishizaki T | | 0，，： | 1 |
| 6 | Dynamic Characteristics of Very- High-Rate GPS Observations for Seismology 显示文摘 | Ebinuma T Kato T | 2012 | Earth Planets and Space2012，64，5： | 1 |
| 7 | Microscopic observation of formation process of clatharate hydrate films at an interface between water and carbon dioxide 显示文摘 | Uchida T Ebinuma T Kawabata J | 1999 | Journal of Crystal Growth1999，204，： | 1 |
| 8 | Effects of pore sizes on dissociation temperatures and pressures of methane,carbon dioxide and propane hydrate in porous media显示文摘 | Uchida T Ebinuma T Takeya S | | 0，，： | 1 |
| 9 | Raman spectroscopic determination of hydration number of methane hydrates显示文摘 | UCHIDA T HIRANO T EBINUMA T | 1999 | AICh E Journal1999，45，12： | 1 |
| 10 | CCR9 + mac- rophages are required for acute liver inflammation in mouse models of hepatitis 显示文摘 | Nakamoto N Ebinuma H Kanai T | 2012 | Gastroenterology2012，142，2： | 1 |
| 11 | Space Charge Behav- ior under AC Voltage in Water-treed PE Observed by the PEA Method显示文摘 | Ying Li Kawai J Ebinuma Y | 1997 | IEEE Transactions on Dielectrics and Elec- trical Insulation1997，4，1： | 1 |
| 12 | In situ X-ray diffraction measurements of the self-preservation effect of CH4 hydrate 显示文摘 | Takeya S Shimada W Kamata Y Ebinuma T Uchida T Nagao J Narita H | 2001 | The Journal of Physical Chemistry A2001，105，42： | 1 |
| 13 | Space charge formation in water-treed insulation显示文摘 | Ohki Y Ebinuma Y Katakai S | 1998 | IEEE Transactions on Dielectrics and Electrical Insula- tion1998，5，5： | 1 |
| 14 | Phase Diagram, Latent Heat, and Specific Heat of TBAB Semielathrate Hydrate Crystals 显示文摘 | Oyama H Shimada W Ebinuma T | 2005 | Fluid Phase Equilibria2005，234，： | 1 |
| 15 | Everything you wanted to know about GNSS simulators but were afraid to ask显示文摘 | PETROVSKI I EBINUMA T | 2010 | GNSS2010，9，4： | 1 |
| 16 | Phase diagram, latent heat, and specific heat of TBAB semiclathrate hydrate crystals显示文摘 | Oyama H Shimada W Ebinuma T | 2005 | Fluid Phase Equilibria2005，234，： | 1 |
| 17 | Selection of marker-free transgenic plants using isopentenyl transferase gene显示文摘 | EBINUMA H SUGITA K MATSUNGA E | 1997 | Proc Natal Acid Sci1997，94，： | 1 |
| 18 | Selection of markerfree transgenic plants using the isopentenyl transferase gene显示文摘 | Ebinuma H Sugita K Matsunaga E | 1997 | Proceedings of the National A- cademy of Sciences of the USA1997，94，： | 1 |
| 19 | Selection of marker-free transgenic plants using the isopentenyl transferase gene as selectable marker显示文摘 | Ebinuma H Sugita K Matsunaga E | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 20 | Gastric cancer incidence based on endoscopic Kyoto classification of gastritis显示文摘BACKGROUND Gastric cancer(GC)incidence based on the endoscopic Kyoto classification of gastritis has not been systematically investigated using time-to-event analysis.AIM To examine GC incidence in an endoscopic surveillance cohort.METHODS This study was retrospectively conducted at the Toyoshima Endoscopy Clinic.Patients who underwent two or more esophagogastroduodenoscopies were enrolled.GC incidence was based on Kyoto classification scores,such as atrophy,intestinal metaplasia(IM),enlarged folds(EFs),nodularity,diffuse redness(DR),and total Kyoto scores.Hazard ratios(HRs)adjusted for age and sex were calculated using a Cox hazard model.RESULTS A total of 6718 patients were enrolled(median age 54.0 years;men 44.2%).During the follow-up period(max 5.02 years;median 2.56 years),GC developed in 34 patients.The average frequency of GCs per year was 0.19%.Kyoto atrophy scores 1[HR with score 0 as reference:3.66,95%confidence interval(CI):1.06 to 12.61],2(11.60,3.82-35.27),IM score 2(9.92,4.37-22.54),EF score 1(4.03,1.63-9.96),DR scores 1(6.22,2.65-14.56),and 2(10.01,3.73-26.86)were associated with GC incidence,whereas nodularity scores were not.The total Kyoto scores of 4(HR with total Kyoto scores 0-1 as reference:6.23,95%CI:1.93 to 20.13,P=0.002)and 5-8(16.45,6.29-43.03,P<0.001)were more likely to develop GC,whereas the total Kyoto scores 2-3 were not.The HR of the total Kyoto score for developing GC per 1 rank was 1.75(95%CI:1.46 to 2.09,P<0.001).CONCLUSION A high total Kyoto score(≥4)was associated with GC incidence.The endoscopy-based diagnosis of gastritis can stratify GC risk. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tatsuya Matsuno Gota Fujisawa Akira Toyoshima Hirotoshi Ebinuma Mitsuhiro Fujishiro Yutaka Saito Hidekazu Suzuki | 2023 | World Journal of Gastroenterology2023，29，31： | 1 |
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