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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 3 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 4 | Hypo- baric treatment stimulates defence-related enzymes in strawberry显示文摘 | HASHMI M S EAST A R PALMER J S | 2013 | Postharvest Biology and Technology2013，85，： | 1 |
| 5 | High-precision U-series dating of corals from Western Australia and implications for the timing and duration of the Last Interglacial显示文摘 | Stirling C H East T M McCulloch M T | 1995 | Earth and Planetary Science Letters1995，，135： | 1 |
| 6 | The Distribution of self-sterility in flowering plants 显示文摘 | East E M | 1940 | Proc Am Philos Soc1940，，82： | 1 |
| 7 | Fatty acids in the Ria Formosa lagoon, Portugal 显示文摘 | Mudge S M East J A Bebianno M J | 1998 | Organic Geochemistry1998，29，4： | 1 |
| 8 | Fatty acids in the Ria Formosa Lagoon,Portugal显示文摘 | Mudge S M East J A Bebianno M J | 1998 | Organic Geochemistry1998，29，4： | 1 |
| 9 | Impact of sitagliptin on markers of beta-cell function:a meta-analysis显示文摘 | Riche D M East H E Richek D | 2009 | Am J med Sci2009，337，5： | 1 |
| 10 | The Relative Incidence of Positive and Negativeword of Mouth: A Multi - category Study显示文摘 | East R Hammond K Wright M | 2007 | International Journal of Research in Marketing2007，24，2： | 1 |
| 11 | Convolutionalback Projection Imaging of Physical Models with Crosshole Seismic Data显示文摘 | East R J R Worthington M H Goulty N R | 1988 | Geophysical Prospecting1988，36，2： | 1 |
| 12 | Lmpact of sitagliptin on markersof beta-cell function :a meta-analysis显示文摘 | Riche D M East H E Riche K D | 2009 | Am J Med Sci2009，33，5： | 1 |
| 13 | ADAMTS5 is the majoraggrecanase in mouse cartilage in vivo and in vitro显示文摘 | Stanton H Rogerson F M East C ] | 2005 | Nature2005，434，7033： | 1 |
| 14 | Crystal structure analysis of warfarin binding to human serum albumin显示文摘 | PETITPAS I BHATTACHARYA A A TWINE S EAST M CURRY S | 2001 | J Biol Chem2001，276，22： | 1 |
| 15 | RNA-programmed genome editing in human cells显示文摘 | Jinek M East A Cheng A | 2013 | Elife2013，2，： | 1 |
| 16 | Narrow band imaging for colonoscopic surveillance in hereditary nonpolyposis colorectal cancer显示文摘 | East JE Suzuki N Stavrinidis M | 2008 | Gut2008，57，1： | 1 |
| 17 | Fish interactions with the sediment-water interface显示文摘 | Cline J M East T L Threlkeld S T | 1994 | Hydrobiologia1994，，1： | 1 |
| 18 | The RelativeIncidence of Positive and Negative Word of Mouth:AMulti-category Study显示文摘 | EAST R HAMMOND K WRIGHT M | 2007 | International Journal of Re-search in Marketing2007，24，2： | 1 |
| 19 | Analysis of DNA encoding 23S rRNA and 16S-23S rRNA intergenic spacer regions from Plesiomonas shigelloides显示文摘 | East A K Allaway D Collins M D | 1992 | FEMS Microbiol Lett1992，95，： | 1 |
| 20 | Recovery of submerged plants from high water stress in a large subtropical lake in Florida,USA显示文摘 | Sharfstein B Brady M A East T L Harwell M C Maki R P Rodusky A J | 2004 | Aquat Bot2004，78，： | 1 |
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