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| 1 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 2 | 极简鞋对足弓结构和足内附肌力量的作用(英文)显示文摘背景:这项前瞻性研究探讨了耐力跑时穿极简鞋和传统跑鞋各自对浅层足内附肌和足纵弓功能的影响。本研究假设穿极简鞋跑步会促使浅层足内附肌肥厚,并导致足弓更高、更强、更硬。方法:将33名健康跑步者随机分为两组:对照组穿传统跑鞋,试验组穿极简跑鞋。用磁共振成像(MRI)在为期12周的训练前后对受试者足部进行扫描,评估训练前后的跑步动力学数据以及足弓高度和硬度。结果:对受试者解剖横截面积和肌肉体积的分析表明,对照组与试验组的趾短屈肌分别增大了11%和21%;试验组小趾展肌的面积和体积分别增长了18%和22%,其纵弓硬度也显著提高(60%)。结论:持久耐力跑时穿4mm或厚度更小的极简鞋需要更多发挥纵弓的弹力功能,因而对支撑足弓的内附肌提出更高要求,从而使足部更强健。 | Elizabeth E.Miller Katherine K.Whitcome Daniel E.Lieberman Heather L.Norton Rachael E.Dyer | 2014 | Journal of Sport and Health Science2014，3，2： | 3 |
| 3 | Variation in Defence Strategies in Two Species of the Genus Beilschmiedia under Differing Soil Nutrient and Rainfall Conditions显示文摘 | J.Simon R. E.Miller I. E.Woodrow | 2008 | Plant Biology2008，，1： | 1 |
| 4 | How Accurate you’re your Performance Appraisals显示文摘 | Corny E.Miller CarlL.Thornton | | 0，，02： | 1 |
| 5 | Strength, Balance, and the Modifying Effects of Obesity and Knee Pain: Results from the Observational Arthritis Study in Seniors (OASIS)显示文摘 | KristenJadelis Michael E.Miller Walter H.Ettinger Stephen P.Messier | 2001 | Journal of the American Geriatrics Society2001，，7： | 1 |
| 6 | China’s corridor bridges:heritage buildings over water显示文摘Essentially unknown in the rest of the world and only recently appreciated in China,the globally significant 3000+‘corridor bridges’(langqiao)in China far outnumber the better-known‘covered bridges’found in North America and Europe.Rivaling or exceeding those in the West in number,age,complexity,and architectural ambition,some of China’s outstanding timber langqiao in the mountains of Fujian and Zhejiang provinces are on the cusp of being inscribed as UNESCO World Heritage cultural sites.Throughout south and central China today there is moreover a resurgence of new timber langqiao being erected using traditional carpentry alongside the unprecedented construction of modern marvels of steel and concrete.Archaeological evidence in 2001 uncovered China’s earliest‘corridor bridge’—thus the oldest known covered bridge in the world—with a length of 42m dating to the Han dynasty 2000 years ago.The Rulong Bridge,which dates to 1625 and is documented as the oldest standing woven arch-beam langqiao,can be visited today in Qingyuan county,southern Zhejiang.Even older langqiao with parallel log beams as the substructure have come to light in neighboring Fujian province,most notably the Zhiqing Bridge in a rural area of Jian’ou city that dates to 1490.China’s bridges,whether with a corridor atop or without,have traditionally not been included under the umbrella of‘vernacular architecture’even as they usually were created by local craftspeople employing the same approaches and practices for dwellings and temples.Just as with these better researched structures,langqiao must be studied not only from the perspective of architecture,but also anthropology,geography,history,and sociology,among other disciplines.Rather than being abandoned as artifacts from the past,China’s langqiao today represent a living tradition that continues serving rural communities as places of passage,spaces for leisure and marketing,sites for worship,and increasingly destinations for tourists in search of nostalgic connections with China’s past.The research presented in this article draws heavily from the authors’China’s Covered Bridges:Architecture over Water,a comprehensive book published in late 2019 in Shanghai and London by Shanghai Jiao Tong University Press that will be distributed in 2020 by the University of Hawai’i Press.Despite the scope of this book,the complexity of China’s langqiao remains understudied. | Ronald G.Knapp Terry E.Miller Jie Liu | 2020 | Built Heritage2020，4，2： | 1 |
| 7 | 1990~2002年英格兰和威尔士亚急性硬化性全脑炎的流行病学调查 | Miller C. AndrewsN Rush M. E.Miller 贺莉 | 2005 | 世界核心医学期刊文摘(儿科学分册)2005，0，6： | 0 |
| 8 | 改进泥浆泵操作方法能减少维修 | 马旭 John E.Miller | 1994 | 国外石油机械1994，，2： | 0 |
| 9 | miRNA在儿童持续性脑震荡后综合征唾液中的表达(摘译)显示文摘在美国,每年有高达两百万的儿童受脑震荡影响,约1/3会发展为持续性脑震荡后综合征(persistent post-concussion syndrome,PPCS),影响时长达数月。相较于未发生PPCS的儿童,该群体更有可能缺课、情绪低落、缺乏社交以及拥有低生活质量。目前预测PPCS风险主要依赖于患者报告的症状和临床体征。 | 陈月亮 宋子翊 周家俊(译) 杨静珍 李丽萍(审校) Katherine E.Miller James P.MacDonald Lindsay Sullivan Lakshmi Prakruthi Rao Venkata Junxin Shi Keith Owen Yeates Su Chen Enas Alshaikh H.Gerry Taylor Amanda Hautmann Nicole Asa Daniel M.Cohen Thomas L.Pommering Elaine R.Mardis Jingzhen Yang the NCH Concussion Research Group | 2023 | 伤害医学(电子版)2023，12，2： | 0 |
| 10 | 北美远程教育:最新进展显示文摘在过去的十年里,网络技术给北美远程教育带来了显著的变化。远程教育实施机构的数量大大增加,形式各异,为机构间的合作提供了新的制度与模式,并将许多远程教育的元素融入传统教育机构的主流结构中。在这一进程中,北美的教育机构同世界上其他地方的类似机构一样,创建新的教学法,运用不断发展的新技术来满足知识社会的需要。 | Gary E.Miller Ken Udas 无 | 2008 | 农民科技培训2008，，12： | 0 |
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