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您的检索式：作者名="E.Eriksson"
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| 1 | p53 as a hub in cellular redox regulation and therapeutic target in cancer显示文摘The TP53 tumor suppressor gene encodes a DNA-binding transcription factor that regulates multiple cellular processes including cell growth and cell death. The ability of p53 to bind to DNA and activate transcription is tightly regulated by post-translational modifications and is dependent on a reducing cellular environment. Some p53 transcriptional target genes are involved in regulation of the cellular redox homeostasis, e.g. TIGAR and GLS2. A large fraction of human tumors carry TP53 mutations, most commonly missense mutations that lead to single amino acid substitutions in the core domain. Mutant p53 proteins can acquire so called gain-of-function activities and influence the cellular redox balance in various ways, for instance by binding of the Nrf2 transcription factor, a major regulator of cellular redox state. The DNA-binding core domain of p53 has 10 cysteine residues, three of which participate in holding a zinc atom that is critical for p53 structure and function. Several novel compounds that refold and reactivate missense mutant p53 bind to specific p53 cysteine residues. These compounds can also react with other thiols and target components of the cellular redox system, such as glutathione. Dual targeting of mutant p53 and redox homeostasis may allow more efficient treatment of cancer. | Sofi E.Eriksson Sophia Ceder Vladimir J.N.Bykov Klas G.Wiman | 2019 | Journal of Molecular Cell Biology2019，11，4： | 4 |
| 2 | Neutrophil secretion products pave the way for inflammatory monocytes显示文摘 | Oliver Soehnlein Alma Zernecke Einar E.Eriksson | | 0，，04： | 1 |
| 3 | Geometric Flow Control Lateral Flow Immunoassay Devices (GFC-LFIDs): A New Dimension to Enhance Analytical Performance显示文摘Te nitrocellulose(NC)membrane based lateral fow immunoassay device(LFID)is one of the most important and widely used biosensor platforms for point-of-care(PoC)diagnostics.However,the analytical performance of LFID has limitations and its optimization is restricted to the bioassay chemistry,the membrane porosity,and the choice of biolabel system.Tese bottom neck technical issues resulted from the fact that the conventional LFID design principle has not evolved for many years,which limited the LFID for advanced biosensor applications.Here we introduce a new dimension for LFID design and optimization based on geometric fow control(GFC)of NC membranes,leading to highly sensitive GFC-LFID.Tis novel approach enables comprehensive fow control via diferent membrane geometric features such as the width(θ)and the length(l)of a constriction,as well as its input angle(θ_(1))and output angle(θ_(2)).Te GFC-LFID(θ=0.5 mm,l=7 mm,θ_(1)=60∘,θ_(2)=45∘)attained a 10-fold increase in sensitivity for detection of interleukin-6(IL-6),compared with conventional LFID,whereas reducing by 10-fold the antibody consumption.Te GFC-LFID detects IL-6 over a linear range of 0.1–10 ng/mL with a limit of detection(LoD)of 29 pg/mL,which even outperforms some commercial IL-6 LFIDs.Such signifcant improvement is attained by pure geometric control of the NC membrane,without additives,that only relaying on a simple high throughput laser ablation procedure suitable for integration on regular large-scale manufacturing of GFC-LFIDs.Our new development on GFC-LFID with the combination of facile scalable fabrication process,tailored fow control,improved analytical performance,and reduced antibodies consumption is likely to have a signifcant impact on new design concept for the LFID industry. | E.Eriksson J.Lysell H.Larsson K.Y.Cheung D.Filippini W.C.Mak | 2019 | Research2019，，1： | 0 |
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