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1461篇 您的检索式:作者名="Dwivedy"
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1Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study显示文摘aim:To assess the endoscopic characteristics of gastric polyps and their association with Helicobacter pylori(H.pylori)status in a predominantly Hispanic population.m ETHODS:We conducted a retrospective study of all esophagogastroduodenoscopies performed at our institution.Demographic,endoscopic and histopathological data were reviewed.Categorization of patients into Hispanic and Non-Hispanic was based on selfidentification.Patients without resection/biopsy were not included in the analysis.Identification of polyps type was based on histological examination.One way analysis of variance was used to compare continuousvariables among different polyp types and Fisher’s exact test was used compare categorical variables among polyp types.Unadjusted and adjusted comparisons of demographic and clinical characteristics were performed according to the H.pylori status and polyp type using logistic regressions.RESULTS:Of 7090 patients who had upper endoscopy,335 patients had gastric polyps(4.7%).Resection or biopsy of gastric polyps was performed in 296 patients(88.4%)with a total of 442 polyps removed or biopsied.Of 296 patients,87(29%)had hyperplastic polyps,82(28%)had fundic gland polyps and 5(1.7%)had adenomatous polyps.Hyperplastic polyps were significantly associated with positive H.pylori status compared with fundic gland polyps(OR=4.621;95%CI:1.92-11.13,P=0.001).Hyperplastic polyps were also found to be significantly associated with portal hypertensive gastropathy compared with fundic gland polyps(OR=6.903;95%CI:1.41-33.93,P=0.0174).Out of 296 patients,30(10.1%)had a followup endoscopy with a mean duration of 26±16.3 mo.Interval development of cancer was not noted in any of the patients during follow up period.CONCLUSi ON:Gastric hyperplastic polyps were significantly associated with positive H.pylori status and portal hypertensive gastropathy as compared with fundic gland polyps.Sherif Elhanafi Mohammed Saadi Wynee Lou Indika Mallawaarachchi Alok Dwivedi Marc Zuckerman Mohamed O Othman 2015World Journal of Gastrointestinal Endoscopy2015,7,10:18
2Ileoscopy in patients with ileocolonic tuberculosis显示文摘AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study. RESULTS: Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only. CONCLUSION: Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up andincreasing the chances of well-timed diagnosis of tuberculosis.SP Misra Vatsala Misra Manisha Dwivedi 2007World Journal of Gastroenterology2007,13,11:16
3Bmi-1:At the crossroads of physiological and pathological biology显示文摘Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.Despite three decades of research that have elucidated the transcriptional regulation,post-translational modifications and functions of Bmi-1 in regulating the DNA damage response,cellular bioenergetics,and pathologies,the entire potential of a protein with such varied functions remains to be realized.This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer.Additionally,since cancer stem cells are emerging as a new paradigm for therapy resistance,the role of Bmi-1 in this perspective is also highlighted.The wide spectrum of malignancies that implicate Bmi-1 as a signature for stemness and oncogenesis also make it a suitable candidate for therapy.Nonetheless,new approaches are vitally needed to further characterize physiological roles of Bmi-1 with the long-term goal of using Bmi-1 as a prognostic marker and a therapeutic target.Resham Bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi 2015Genes & Diseases2015,2,3:15
4Gall bladder carcinoma: Aggressive malignancy with protean loco-regional and distant spread显示文摘The most common malignancy of biliary tract is gallbladder cancer(GBC) which is the third most common cancer in gastrointestinal tract. It is a lethal disease for most patients in spite of growing awareness and improved diagnostic techniques. GBC has a verypoor prognosis and the 5 year survival rate is < 10%. Although etiology of the carcinoma of the gallbladder is still obscure, various factors have been implicated, cholelithiasis being the most frequent. The incidence of GBC worldwide is based on the gender, geography and ethnicity which suggest that both genetic and environmental factors can cause GBC. The major route of spread of gallbladder cancer(GC) is locoregional rather than distant. It spreads by lymphatic, vascular, neural, intraperitoneal, and intraductal routes. Sonography is usually the most common imaging test to evaluate symptoms of biliary tract disease including suspected GC. With recent advances in imaging modalities like multi-detector computed tomography(CT) scanners, magnetic resonance imaging-positron emission tomography/CT diagnosis of gallbladder cancer has improved. Studies have also targeted molecular and genetic pathways. Treatment options have included extended and radical surgeries and adjuvant chemotherapy. This review article deals in detail with important aspects of carcinoma gallbladder and its manifestations and challenges. Role of various imaging modalities in characterization and accurate staging has been discussed. The loco-regional spread of this aggressive malignancy is dealt explicitly.Amit Nandan Dhar Dwivedi Shivi Jain Ruhi Dixit 2015World Journal of Clinical Cases2015,3,3:14
5MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer显示文摘Epithelial ovarian cancer(EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers(mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as micro RNAs(miRNAs) for cancer diagnosis and prognosis. MiRNAs are a novel class of small non-coding RNAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRNA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRNAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRNAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRNAs involved in ovarian carcinoma to establish mi RNAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DNA biomarkers.Manish K.Pal Shyam P.Jaiswar Vinaya N.Dwivedi Amit K.Tripathi Ashish Dwivedi Pushplata Sankhwar 2015Cancer Biology & Medicine2015,12,4:12
6Improving Drought Tolerance of Rice by Designed QTL Pyramiding显示文摘Drought is the most important factor limiting rice yields in the rainfed areas of Asia. To overcome the problem, we developed a new strategy 'designed QTL pyramiding' to more effi ciently develop drought tolerant (DT)Z.K. Li D. Dwivedi Y.M. Gao T.Q. Zheng R. Lafitte J.L. Xu D. Mackill B.Y. Fu J.Domingo Y. Sun L.H. Zhu 2007分子植物育种2007,5,2:12
7A Comparison of SWAT Model Calibration Techniques for Hydrological Modeling in the Ganga River Watershed显示文摘恒河是印度最长的河流,目前正遭受人类活动和气候变化的影响,其中瓦拉纳西区域所受的影响尤为严重。预计气候变化和不断扩张的人口会进一步影响水资源的有效利用。本研究利用水土评价工具(soil and water assessment tool,SWAT)模型进行水文模拟,研究区选择恒河流经的印度北方邦南部地区,覆盖面积达15 621.612 km^2。本研究主要目标如下:(1)检验SWAT模型在径流和产沙量预测方面的可行性和适用性,(2)对序贯不确定性分析(SUFI-2)、普适似然不确定性估计(GLUE)和并行求解(ParaSol)这3种常规校准算法进行对比分析,并确定出最佳校准算法。SWAT模型中输入数据的来源为航天飞机雷达地形测绘任务(SRTM)获取的数字高程模型(DEM)、Landsat-8卫星图像、土壤数据和逐日气象数据。首先,本研究将研究流域划分为46个子流域,使用土地利用/土地覆被(LULC)图和土壤图创建了水文响应单元(HRU)。然后,构建了基于SUFI-2、GLUE和ParaSol算法的模型,并基于5类标准对这些校准算法进行了比较,标准包括目标函数、使用概念、性能、P因子和R因子值。研究结果表明:(1) SUFI-2算法需要的运行时间较少,同时校准结果最好,ParaSol算法最差;(2)使用SUFI-2算法对模型进行校准后,获得对模拟结果影响最显著的5个敏感参数——主河道水力传导率(CH_K2)、USLE方程水土保持因子(USLE_P)、主河道曼宁系数值(CH_N2)、地表径流滞后时间(SURLAG)以及土壤有效含水量(SOL_AWC);(3) 40号子流域(SW#40)产生的径流量最大,土地利用类型为荒地的36号子流域(SW#36)的产沙量最大,达到50 t·a^(–1)。研究区的平均蒸散量为411.55 mm·a^(–1)。校准后的模型可以用于探究未来LULC的变化、气候变化和土壤侵蚀的影响。Nikita Shivhare Prabhat Kumar Singh Dikshir Shyam Bihari Dwivedi 2018Engineering2018,4,5:6
8A comprehensive review on energy storage in hybrid electric vehicle显示文摘The sharp inclination in the emissions from conventional vehicles contribute to a significant increase in environmental issues,besides the energy crises and low conversion efficiency leads to the evolution of electric vehicles(EV).Hybrid electric vehicles(HEV) have efficient fuel economy and reduce the overall running cost,but the ultimate goal is to shift completely to the pure electric vehicle.Despite this,the main obstruction of HEV is energy storage capability.An EV requires high specific power(W/kg) and high specific energy(W$h/kg) to increase the distance travelled and reduce the time required for charging.The main focus of this paper is on the energy sources as these are the main components in EVs towards making them eco-friendly and cost-effective.Various topologies of EV technology such as HEVs,plug-in HEVs,and many more have been discussed.These topologies of EVs are based on the diverse combination of batteries,fuel cells,super-capacitor,flywheels,regenerative braking systems,which are used as energy sources and energy storage devices.Shrey Verma Shubham Mishra Ambar Gaur Subhankar Chowdhury Subhashree Mohapatra Gaurav Dwivedi Puneet Verma 2021Journal of Traffic and Transportation Engineering(English Edition)2021,8,5:6
9Helicobacter pylori and gastric cancer: Indian enigma显示文摘Helicobacter pylori(H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric cancer. The geographical distribution and etiology of gastric cancer differ widely in different geographical regions and H. pylori, despite being labeled as a grade Ⅰ carcinogen, has not been found to be associated with gastric cancer in many areas. Studies in Asian countries such as Thailand, India, Bangladesh, Pakistan, Iran, Saudi Arabian countries, Israel and Malaysia, have reported a high frequency of H. pylori infection co-existing with a low incidence of gastric cancer. In India, a difference in the prevalence of H. pylori infection and gastric cancer has been noted even in different regions of the country leading to a puzzle when attempting to find the causes of these variations. This puzzle of H. pylori distribution and gastric cancer epidemiology is known as the Indian enigma. In this review we have attempted to explain the Indian enigma using evidence from various Indian studies and from around the globe. This review covers aspects of epidemiology, the various biological strains present in different parts of the country and within individuals, the status of different H. pylori-related diseases and the molecular pathogenesis of the bacterium.Vatsala Misra Renu Pandey Sri Prakash Misra Manisha Dwivedi 2014World Journal of Gastroenterology2014,20,6:6
10Improved simultaneous quantitation of candesartan and hydrochlorthiazide in human plasma by UPLC–MS/MS and its application in bioequivalence studies显示文摘A validated ultra-performance liquid chromatography mass spectrometric method(UPLC–MS/MS) was used for the simultaneous quantitation of candesartan(CN) and hydrochlorothiazide(HCT) in human plasma. The analysis was performed on UPLC–MS/MS system using turbo ion spray interface.Negative ions were measured in multiple reaction monitoring(MRM) mode. The analytes were extracted using a liquid–liquid extraction(LLE) method by using 0.1 mL of plasma volume. The lower limit of quantitation for CN and HCT was 1.00 ng/mL whereas the upper limit of quantitation was 499.15 ng/mL and601.61 ng/mL for CN and HCT respectively. CN d4 and HCT-13Cd2 were used as the internal standards for CN and HCT respectively. The chromatography was achieved within 2.0 min run time using a C18 Phenomenex, Gemini NX(100 mm 4.6 mm, 5 mm) column with organic mixture:buffer solution(80:20, v/v) at a flow rate of 0.800 mL/min. The method has been successfully applied to establish the bioequivalence of candesartan cilexetil(CNC) and HCT immediate release tablets with reference product in human subjects.Bhupinder Singh Rama S.Lokhandae Ashish Dwivedi Sandeep Sharma Naveen Dubey 2014Journal of Pharmaceutical Analysis2014,4,2:5
11Software design pattern mining using classification-based techniques显示文摘Ashish Kumar DWIVEDI Anand TIRKEY Santanu Kumar RATH 2018Frontiers of Computer Science2018,12,5:5
12Modeling the Contemporary Stress Field and Deformation Pattern of Eastern Mediterranean显示文摘The contemporary stress field in the earth's crust is important and provides insights into mechanisms that drive plate motions.In this study,elastic plane stress finite element modeling incorporating realistic rock parameters was used to calculate the stress field,displacement field,and deformation of the plate interactions in the eastern Mediterranean.Modeled stress data for the African-Arabian-Anatolian plate interactions with fixed European platform correlate well with observed contemporary stress indicator from the world stress map(WSM) and focal mechanism of earthquakes;while displacement field agrees qualitatively well with GPS vectors and sense of motion indicated by focal mechanisms for large crustal earthquakes(Ms>6) and plate motion models.Modeling result shows the direction of maximum horizontal compressive stress(σHmax) toward the direction of absolute motion of these plates.Large perturbations in σHmax orientations are shown to occur in and around tectonic boundaries between those plates.It is observed that,although the African plate acts mostly as indenter,which transmits the collisional motion from the Arabian plate to the Anatolian plate,in the current situation,the far-field stress,probably from the subduction in Aegean Arc,is needed to satisfy the contemporary stress field in Anatolia.S K Dwivedi D Hayashi 2010Journal of Earth Science2010,21,4:5
13A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin 2012Cell Research2012,22,11:5
14Pharmacological properties of Datura stramonium L. as a potential medicinal tree:An overview显示文摘India has a great wealth of various naturally occurring plant drugs which have great potential pharmacological activities.Datura stramonium(D.stramonium is one of the widely well known folklore medicinal herbs.The troublesome weed,D.stramonium is a plant with both poisonous and medicinal preperties and has been proven to have great pharmacological potential with a great utility real usage in folklore medicine.D.stromonium has been scientifically proven to contain alkaloids,tannins,carbohydrates and proteins.This plant has contributed various pharmacological actions in the scientific field of Indian systems of medicines like analgesic and antiasthmatic activities.The present paper presents an exclusive review work on the ethnomedical,phytochemical,pharmacological activities of this plant.Priyanka Soni Anees Ahmad Siddiqui Jaya Dwivedi Vishal Soni 2012Asian Pacific Journal of Tropical Biomedicine2012,2,12:5
15Blockchain-Based Secured IPFS-Enable Event Storage Technique With Authentication Protocol in VANET显示文摘In recent decades,intelligent transportation systems(ITS)have improved drivers’safety and have shared information(such as traffic congestion and accidents)in a very efficient way.However,the privacy of vehicles and the security of event information is a major concern.The problem of secure sharing of event information without compromising the trusted third party(TTP)and data storage is the main issue in ITS.Blockchain technologies can resolve this problem.A work has been published on blockchain-based protocol for secure sharing of events and authentication of vehicles.This protocol addresses the issue of the safe storing of event information.However,authentication of vehicles solely depends on the cloud server.As a result,their scheme utilizes the notion of partially decentralized architecture.This paper proposes a novel decentralized architecture for the vehicular ad-hoc network(VANET)without the cloud server.This work also presents a protocol for securing event information and vehicle authentication using the blockchain mechanism.In this protocol,the registered user accesses the event information securely from the interplanetary file system(IPFS).We incorporate the IPFS,along with blockchain,to store the information in a fully distributed manner.The proposed protocol is compared with the state-of-the-art.The comparison provides desirable security at a reasonable cost.The evaluation of the proposed smart contract in terms of cost(GAS)is also discussed.Sanjeev Kumar Dwivedi Ruhul Amin Satyanarayana Vollala 2021IEEE/CAA Journal of Automatica Sinica2021,8,12:4
16Ileocecal masses in patients with amebic liver abscess:Etiology and management显示文摘瞄准:与阿米巴的肝脓肿在病人估计回盲肠质量的原因。方法:有阿米巴的肝脓肿和回盲肠质量的病人被结肠镜检查和活体检视材料的组织学的检查在结肠镜检查期间从损害跟随的提高对比的 CT 扫描小心地检查并且调查。结果:回盲肠群众与阿米巴的肝脓肿在十七个病人被发现。团的原因是在 14 个病人,的阿米巴瘤在在 1 个病人的盲肠的 2 个病人和腺癌的盲肠的肺结核。结肠的溃疡在中的五个被注意六(83%) 有在表示的活跃腹泻的病人。在所有这些病人的回盲肠团是阿米巴瘤。溃疡被看见在仅仅之一 11 (9%) 没有腹泻的病人。差别来自有腹泻(P< 0.005 ) 的组是统计上重要的。结论:回盲肠质量不是与阿米巴的肝脓肿的在病人的不平常的发现。尽管,回盲肠团由于在大多数情况中的阿米巴瘤形成,这是在所有病人的案例,这不应该被假定。结肠镜检查和目标活体检视的组织学的检查是强制的避免错过更不祥的损害。Sri Prakash Misra Vatsala Misra Marisha Dwivedi 2006World Journal of Gastroenterology2006,12,12:3
17Stability analysis of a thin-walled cylinder in turning operation using the semi-discretization method显示文摘In this work, the stability of a flexible thin cylindrical workpiece in turning is analyzed. A process model is derived based on a finite element representation of the workpiece flexibility and a nonlinear cutting force law. Repeated cutting of the same surface due to overlapping cuts is modeled with the help of a time delay. The stability of the so obtained system of periodic delay differential equations is then determined using an approximation as a time-discrete system and Floquet theory. The time-discrete system is obtained using the semi-discretization method. The method is implemented to analyze the stability of two different workpiece models of different thicknesses for different tool positions with respect to the jaw end. It is shown that the stability chart depends on the tool position as well as on the thickness.Arnab Chanda Achim Fischer Peter Eberhard Santosha Kumar Dwivedy 2014Acta Mechanica Sinica2014,30,2:3
18Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients显示文摘Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell(CSC)population after 3 cycles of standard chemotherapy.The epigenetic response(miRNAs expression)and CSCs are also correlated in patients with Breast Cancer.In patients who tolerated chemotherapy well,miRNA-21(non-coding RNA)expression decreased significantly after three cycles of chemotherapy.The miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR(real-time PCR)using the standard protocol.In addition,breast CSCs(CD44+/CD24-)were also decreased in these patients.The miRNA-21 regulates cell division,proliferation,and autophagy of cancerous cells(as it targets phosphatase and tensin homolog/AKT/transcription factor EB/programmed cell death 4/autophagy-related protein 5 and chemotherapy also produces similar effects),thereby contributing to these benefits.Therefore,when all of the targets on genes have been explored by mimic miRNA,chemotherapy combined with anti-miRNA21 therapy may prove useful in the care of cancer patients.Shailendra Dwivedi Puneet Pareek Jeewan Ram Vishnoi Praveen Sharma Sanjeev Misra 2022World Journal of Stem Cells2022,14,4:3
19Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil显示文摘Arvind Pandey Kanchan Vishnoi Sutapa Mahata Satyendra Chandra Tripathi Sri Prakash Misra Vatsala Misra Ravi Mehrotra Manisha Dwivedi Alok C. Bharti 2015Nutrition and Cancer2015,,8:2
20急性心肌梗死后早期经心肌声学造影检测心肌存活力的预后价值显示文摘目的:本研究旨在确定急性心肌梗死(AMI)后经心肌声学造影(MCE)所检测的残余心肌存活力能否预测硬性心脏事件的发生。背景:已有研究显示经MCE所测定的心肌存活力可以预测AMI患者左心室(LV)功能的恢复状况。不过。Dwivedi G. Janardhanan R. Hayat S.A. R. Senior 刘相飞 2007世界核心医学期刊文摘(心脏病学分册)2007,,11:2
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