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| 1 | Vitamin D and autoimmune thyroid diseases显示文摘The role of vitamin D as an immune modulator has been emphasized in recent years,and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus.Vitamin D mediates its effect though binding to vitamin D receptor(VDR),and activation of VDR-responsive genes.While VDR gene polymorphism was found to associate with autoimmune thyroid diseases(AITDs),few studies examined levels of vitamin D in these patients and those that did yielded conflicting results.We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls.Serum vitamin D(25-OH)levels were measured in 50 patients with AITDs,42 patients with non-AITDs and 98 healthy subjects,utilizing the LIAISON chemiluminescence immunoassay(DiaSorin,Saluggia,Italy).VitaminD deficiency was designated at levels lower than 10 ng/ml.Antithyroid antibodies,thyroid functions and demographic parameters were evaluated in all patients.The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals(72% versus 30.6%;P<0.001),as well as in patients with Hashimoto’s thyroiditis compared to patients with non-AITDs(79% versus 52%;P<0.05).Vitamin D deficiency also correlated to the presence of antithyroid antibodies(P=0.01)and abnormal thyroid function tests(P=0.059).Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests,suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation. | Shaye Kivity Nancy Agmon-Levin Michael Zisappl Yinon Shapira Endre V Nagy Katalin Danko Zoltan Szekanecz Pnina Langevitz Yehuda Shoenfeld | 2011 | Cellular & Molecular Immunology2011，8，3： | 47 |
| 2 | Pre-and intraoperative predictors of acute kidney injury after liver transplantation显示文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors. | Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 3 | Liver transplantation and aging显示文摘An increase in the average life expectancy,paralleled by a demographic shift in the population with end-stage liver disease lies behind the rising demand for liver transplantation(LT)among the elderly.Some of the most common indications for LT including hepatocellular carcinoma,alcohol-related liver disease,chronic hepatitis C and non-alcoholic fatty liver disease tend to affect older patients.Transplant professionals are faced with an increasing demand for LT among elderly patients in an age of organ shortage and it is important that risk and benefits are carefully weighed in order to achieve the optimum use of precious liver grafts. | Danko Mikulic Anna Mrzljak | 2020 | World Journal of Transplantation2020，10，9： | 4 |
| 4 | Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis显示文摘 | Ordog T Baldo M Danko R | 2000 | Diabetes2000，49，10： | 2 |
| 5 | Liver transplantation for benign liver tumors显示文摘Benign liver tumors are common lesions that are usually asymptomatic and are often found incidentally due to recent advances in imaging techniques and their widespread use.Although most of these tumors can be managed conservatively or treated by surgical resection,liver transplantation(LT)is the only treatment option in selected patients.LT is usually indicated in patients that present with life-threatening complications,when the lesions are diffuse in the hepatic parenchyma or when malignant transformation cannot be ruled out.However,due to the significant postoperative morbidity of the procedure,scarcity of available donor liver grafts,and the benign course of the disease,the indications for LT are still not standardized.Hepatic adenoma and adenomatosis,hepatic hemangioma,and hepatic epithelioid hemangioendothelioma are among the most common benign liver tumors treated by LT.This article reviews the role of LT in patients with benign liver tumors.The indications for LT and long-term outcomes of LT are presented. | Ana Ostojic Anna Mrzljak Danko Mikulic | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 6 | Emerging and neglected zoonoses in transplant population显示文摘Zoonoses represent a problem of rising importance in the transplant population.A close relationship and changes between human,animal and environmental health(“One Health”concept)significantly influence the transmission and distribution of zoonotic diseases.The aim of this manuscript is to perform a narrative review of the published literature on emerging and neglected zoonoses in the transplant population.Many reports on donor-derived or naturally acquired(re-)emerging arboviral infections such as dengue,chikungunya,West Nile,tick-borne encephalitis and Zika virus infection have demonstrated atypical or more complicated clinical course in immunocompromised hosts.Hepatitis E virus has emerged as a serious problem after solid organ transplantation(SOT),leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes.Some neglected pathogens such as lymphocytic choriomeningitis virus can cause severe infection with multi-organ failure and high mortality.In addition,ehrlichiosis may be more severe with higher casefatality rates in SOT recipients.Some unusual or severe presentations of borreliosis,anaplasmosis and rickettsioses were also reported among transplant patients.Moreover,toxoplasmosis as infectious complication is a well-recognized zoonosis in this population.Although rabies transmission through SOT transplantation has rarely been reported,it has become a notable problem in some countries.Since the spreading trends of zoonoses are likely to continue,the awareness,recognition and treatment of zoonotic infections among transplant professionals should be imperative. | Anna Mrzljak Rafaela Novak Nenad Pandak Irena Tabain Lucija Franusic Ljubo Barbic Maja Bogdanic Vladimir Savic Danko Mikulic Jadranka Pavicic-Saric Vladimir Stevanovic Tatjana Vilibic-Cavlek | 2020 | World Journal of Transplantation2020，10，3： | 2 |
| 7 | Adolescent coping styles and perceptions of parental child rearing显示文摘 | Dusek J B Danko M | | 0，，04： | 1 |
| 8 | Detection of TT virus in patients with idiopathic inflammatory myopathies显示文摘 | Gergely P Jr Blazsek A Danko K | 2005 | Ann N Y Acad Sci2005，1050，： | 1 |
| 9 | Bucket trajectory classifi- cation of mining excavators显示文摘 | TIWARI R KNOWLES J DANKO G | 2013 | Automation in Construction2013，31，5： | 1 |
| 10 | Morbidity after cesarean section显示文摘 | Visnovsky J Tomas S Danko J | 2003 | Ceska Gynekol2003，68，4： | 1 |
| 11 | New therapeutic approaches for polymyositis and dermatomyositis显示文摘 | Danko K Vincze M | 2011 | Orv Hetil2011，152，39： | 1 |
| 12 | In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract 显示文摘 | Hunyadi A Veres K Danko B | 2013 | Phytother Res2013，27，6： | 1 |
| 13 | The efficient expression of intravascularly delivered DNA in rat muscle 显示文摘 | Budker V Zhang G Danko I | 1998 | Gene Ther1998，5，2： | 1 |
| 14 | Complications of video-mediasfinoscopy-successful management in four cases显示文摘 | Pereszlenyi A Jr Niks M Danko J | 2003 | Bratisl Lek Listy2003，104，6： | 1 |
| 15 | Color Doppler flowimaging in detection and quantitative of ovarian tumors显示文摘 | ARTHUR C MUNO J DANKO J | 2003 | JUltrasound2003，12，1： | 1 |
| 16 | EEG changes in comparison of rest states with open and closed eyes in complete darkness显示文摘 | BoItsova IuA Danko S G | | 0，，03： | 1 |
| 17 | 转染及培养条件对外源性钙离子ATP酶SERCA1a表达的影响显示文摘目的评估不同转染及培养条件下COS1细胞过表达钙离子ATP酶SERCA1a的量及活性,探讨影响真核细胞目标蛋白质表达量及活性的因素。方法应用常规的全量或者半量DNA、lipofactamin和plus reagent转染COS1细胞,37℃、34℃或31℃培养2至5d。提取微粒体蛋白后定量并测定SERCA1a的ATP酶活性。结果微粒体蛋白量在细胞培养3至4d达到高峰,改变转染及细胞培养条件,未见明显变化;降低细胞培养温度及提高DNA转染用量,可增加SERCA1a表达量;SERCA1a表达量在8μg DNA转染细胞31℃培养3d达到最高,然而降低细胞培养温度后,SERCA1a的ATP酶活性及EP生成量也随之下降;31℃表达的SERCA1a,其ATP酶活性降低比EP生成量减少的幅度更大,并且ATP酶活性及EP生成量随着细胞培养时间延长而增加。结论应用常规的半量转染试剂、全量DNA瞬时转染COS1细胞,37℃培养3-4d可获得最大量具有正常酶活性的SERCA1a蛋白。降低培养温度虽然可以提高外源性SERCA1a的表达,但却可能影响细胞内蛋白质的准确折叠及正常降解。 | 王国丽 大宝贵嗣 山崎和生 Stefania Danko 铃木裕 | 2014 | 中国组织化学与细胞化学杂志2014，23，3： | 1 |
| 18 | Pharmacological en-hancement of in vivo foreign gene expression in muscle显示文摘 | Danko I Fritz J D Wolff J A | 1994 | Gene Ther1994，1，2： | 1 |
| 19 | A Nationwide Survey ofSterile Supply,Processing and Distribution(SPD)Services withinDepartment of Veterans Affairs(VA)Medical Facilities显示文摘 | Danko LH Simbartl LA Osburn B | 2006 | AmericanJournal of Infection Control2006，34，1： | 1 |
| 20 | A Conceptual and Empirical Comparison of Alternative Household Life Cycle Models 显示文摘 | Schaninger C M and Danko W D | 1993 | Journal of Consumer Research1993，19，3： | 1 |
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