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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Turner' s syndrome in adulthood 显示文摘 | Elsheikh M Dunger D B Conway G S | 2002 | Endocrine Reviews2002，23，1： | 1 |
| 3 | Expression analy- sis of small heat shock proteins during compatible and incompat- ible plant-pathogen interactions显示文摘 | Garofalo C G Garavaglia B S Dunger G | 2009 | Advanced Studies in Biology2009，1，： | 1 |
| 4 | Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘 | OBERMEIER F DUNGER N STRAUCH U G | 2003 | Clin Exp Immunol2003，134，2： | 1 |
| 5 | Contrasting activity of cytosine-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘 | Obermeier F Dunger N Strauch U G | 2003 | Clin Exp Immunol2003，134，： | 1 |
| 6 | Improved in vivo pancreatic islet function after prolonged in vitro islet culture显示文摘 | Fraga DW Callicutt CS Gerling IC Sabek OM Kotb MY Dimitriadis G Crowne E Clark A Dunger DB | 2001 | Transplantation2001，72，11： | 1 |
| 7 | Contrasting activ- ity of eytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis 显示文摘 | Obermeier F Dunger N Strauch U G | 2003 | Ciin Exp Immunol2003，134，2： | 1 |
| 8 | Improved in vivo pancreatic islet function after prolonged in vitro islet culture 显示文摘 | Gaber AO Fraga DW Callicutt CS Gerling IC Sabek OM Kotb MY Dimitriadis G Crowne E Clark A Dunger DB | 2001 | Transplantation2001，72，11： | 1 |
| 9 | Xan- thomonascitri subsp, cirri type IV pilns is required for twitching motility, biofilm development, and adher- ence 显示文摘 | Dunger G Guzzo C R Andrade M O | 2014 | Molecular Plant-Microbe Interactions2014，27，10： | 1 |
| 10 | Mctabolicsyn- drome in childrenunravelled 显示文摘 | Thankamony G N A Williams R Dunger D B | 2011 | Pediatrics and Child Health2011，21，7： | 1 |
| 11 | Contrasting activity of cy- tosine-guanosin dinucleotide oligonucleotides in mice with experimen- tal colitis 显示文摘 | Obermeier F Dunger N Strauch U G | 2003 | Clin Exp Inununo12003，134，： | 1 |
| 12 | 胎儿印记基因和孕妇血压之间的关系显示文摘除了母体基因和环境影响因素,胎儿印记基因的变化也可影响怀孕期间的母亲血压。该研究的目的是测试在2个已建立的出生队列(剑桥婴儿生长和健康研究)中1160个DNA三联体的16个印迹基因的多态性与母体平均动脉压之间的关系,并试图验证在1367例高血糖和不良妊娠结局研究受试者中是否存在同样的关系。 | 刘莉 叶鹏 Petry CJ Sanz Marcos N Pimentel G Hayes MG Nodzenski M Scholtens DM Hughes IA Acerini CL Ong KK Lowe WL Jr Dunger DB | 2016 | 中华高血压杂志2016，24，12： | 0 |
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