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| 1 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 2 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 3 | The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude显示文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude. | Lin-Jie Wei Chi Lin Xing-Sen Xue Guo-Dong Dun Jian-Bo Zhang Yan-Xiang Tong Jia-Xiong Wang Shi-Ji Yang Ling Wang Zhi Chen Hua Feng Gang Zhu | 2021 | Chinese Journal of Traumatology2021，24，6： | 11 |
| 4 | Jittor:a novel deep learning framework with meta-operators and unified graph execution显示文摘This paper introduces Jittor,a fully just-in-time(JIT)compiled deep learning framework.With JIT compilation,we can achieve higher performance while making systems highly customizable.Jittor provides classes of Numpy-like operators,which we call meta-operators.A deep learning model built upon these meta-operators is compiled into high-performance CPU or GPU code in real-time.To manage metaoperators,Jittor uses a highly optimized way of executing computation graphs,which we call unified graph execution.This approach is as easy to use as dynamic graph execution yet has the efficiency of static graph execution.It also provides other improvements,including operator fusion,cross iteration fusion,and unified memory. | Shi-Min HU Dun LIANG Guo-Ye YANG Guo-Wei YANG Wen-Yang ZHOU | 2020 | Science China(Information Sciences)2020，63，12： | 10 |
| 5 | Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities显示文摘Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of AD.Previous studies have demonstrated that the cognitive impairment of AD is associated with oxidative stress and the inhibition of AKT and ERK phosphorylation.Grape seed proanthocyanidin extract(GSPE)has been shown to have strong antioxidant effect and can protect the nervous system from oxidative stress damage.This study aimed to investigate the protective effect of GSPE on the cognitive and synaptic impairments of AD using a sporadic AD rat model induced by intracerebroventricular(ICV)injection of streptozotocin(STZ)(ICV-STZ).Rats were treated with GSPE(50,100,or 200 mg/kg every day)by intragastrical(ig.)administration for continuous 7 weeks,and ICV-STZ(3 mg/kg)was performed on the first day and third day of week 5.Learning and memory abilities were assessed by the Morris water maze(MWM)test at week 8.After behavioral test,hippocampal long-term potentiation(LTP)was recorded,and the levels of malondialdehyde(MDA),superoxide dismutases(SOD),glutathione(GSH)and the protein expression of AKT and ERK were measured in the hippocampus and cerebral cortex of rats.Our study revealed that ICV-STZ significantly impaired the working learning ability and hippocampal LTP of rats,significantly increased the levels of MDA,and decreased the activity of SOD and GSH in the hippocampus and cerebral cortex.In contrast,GSPE treatment prevented the impairment of cognitive function and hippocampal LTP induced by ICV-STZ,decreased the level of MDA,and increased the level of SOD and GSH.Furthermore,Western blot results showed that GSPE treatment could prevent the loss of AKT and ERK activities in the hippocampus and cerebral cortex induced by ICV-STZ.Our findings demonstrate that GSPE treatment could ameliorate the impairment of cognitive ability and hippocampal synaptic plasticity in a rat model of sporadic AD by inhibiting oxidative stress and preserving AKT and ERK activities.Therefore,GSPE may be an effective agent for the treatment of cognitive deficits associated with sporadic AD. | Wei-li GAO Xiang-hua LI Xin-peng DUN Xiao-kuan JING Ke YANG Yan-kun LI | 2020 | Current Medical Science2020，40，3： | 8 |
| 6 | Aquaporin-4 and ischemic brain edema显示文摘OBJECTIVE:To investigate the relationship of aquaporin 4(AQP4)and brain edema.DATA SOURCES:Using the terms of 'aquaporin-4,brain edema',we searched PubMed database to identify studies published from January 1997 to April 2006 in the English languages.Meanwhile,we also searched China National Knowledge Infrastructure(CNKI)for related studies.STUDY SELECTION:The collected data were selected firstly.Studies on AQP4 and brain edema were chosen and their full-texts were searched for,and those with repetitive or review studies were excluded.DATA EXTRACTION:Totally 146 related studies were collected,42 of them were involved and the other 104 studies were used for reading reference data.DATA SYNTHESIS:AQP4 is a selective water permeable integral membrane protein.It is mainly expressed in astrocytes and ependymocyte,and is the important structural basis for water regulation and transportation between glial cells and cerebrospinal fluid or vessels.Phosphorylation is involved in the regulation of AQP4.AQP4 participates in the formation of brain edema caused by various factors.Studies on the structure and pathological changes of AQP4 are still in the initial stage,and the role and mechanism of AQP4 in the formation of brain edema is very unclear.CONCLUSION:AQP4 plays a critical regulating role in the formation of ischemic brain edema,but whether it is regulated by drugs lacks reliable evidence. | Saihong Dun Yang Guo | 2007 | Neural Regeneration Research2007，2，4： | 6 |
| 7 | Broadband, sensitive and spectrally distinctive SnS_(2) nanosheet/PbS colloidal quantum dot hybrid photodetector显示文摘Photodetectors convert photons into current or voltage outputs and are thus widely used for spectroscopy,imaging and sensing.Traditional photodetectors generally show a consistent-polarity response to incident photons within their broadband responsive spectrum.Here we introduced a new type of photodetector employing SnS_(2) nanosheets sensitized with PbS colloidal quantum dots(CQDs)that are not only sensitive(~105AW−1)and broadband(300–1000 nm)but also spectrally distinctive,that is,show distinctive(positive or negative)photoresponse toward incident photons of different wavelengths.A careful mechanism study revealed illumination-modulated Schottky contacts between SnS_(2) nanosheets and Au electrodes,altering the photoresponse polarity toward incident photons of different wavelengths.Finally,we applied our SnS_(2) nanosheet/PbS CQDs hybrid photodetector to differentiate the color temperature of emission from a series of white light-emitting diodes(LEDs),showcasing the unique application of our novel photodetectors. | Liang Gao Chao Chen Kai Zeng Cong Ge Dun Yang Haisheng Song Jiang Tang | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 8 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 9 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 10 | Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in colortunable organic electroluminescent devices显示文摘In this work,we show that the spin dynamics of excitons can be dramatically altered by Maxwell magnetic field coupling,together with an ion-enhanced,low-internal-splitting-energy organic semiconducting emitter.By employing a unique,alternating current(AC)-driven organic electroluminescent(OEL)device architecture that optimizes this magnetic field coupling,almost complete control over the singlet-to-triplet ratio(from fluorescent to phosphorescent emission in a single device)is realized.We attribute this spin population control to magnetically sensitive polaron–spin pair intersystem crossings(ISCs)that can be directly manipulated through external driving conditions.As an illustration of the utility of this approach to spin-tailoring,we demonstrate a simple hybrid(double-layer)fluorescence–phosphorescence(F–P)device using a polyfluorene-based emitter with a strong external Zeeman effect and ion-induced long carrier diffusion.Remarkable control over de-excitation pathways is achieved by controlling the device-driving frequency,resulting in complete emission blue–red color tunability.Picosecond photoluminescence(PL)spectroscopy directly confirms that this color control derives from the magnetic manipulation of the singlet-totriplet ratios.These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature. | Junwei Xu Yue Cui Gregory M.Smith Peiyun Li Chaochao Dun Linqi Shao Yang Guo Hongzhi Wang Yonghua Chen David L.Carroll | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 11 | The relationship betweenpolymorphisms in the promoter region of Tim-3 and un-explained recurrent spontaneous abortion in Han Chinesewomen显示文摘 | Yang S Chen W Dun H | 2013 | Reprod Biol Endocrinol2013，11，11： | 1 |
| 12 | High-fat diet causeslipotoxicity responses in cumulus-oocyte complexes and decreasedfertilization rates 显示文摘 | WU L L Dunning K R YANG X | 2010 | Endocrinology2010，151，11： | 1 |
| 13 | Rapid formation of a supramolecular polypeptide-DNA hydrogel for in situ three-dimensional multilayer bioprinting显示文摘 | LI C FAULKNER-JONES A DUN A R JIN J CHEN P X1NG Y YANG Z LI Z SHU W LIU D DUNCAN R R | 2015 | Angewandte Chemie International Edition2015，54，： | 1 |
| 14 | Rapid Formation of a Supramolecular Polypeptide–DNA Hydrogel for In Situ Three‐Dimensional Multilayer Bioprinting显示文摘 | Chuang Li Alan Faulkner‐Jones Alison R. Dun Juan Jin Ping Chen Yongzheng Xing Zhongqiang Yang Zhibo Li Wenmiao Shu Dongsheng Liu Rory R. Duncan | 2015 | Angew. Chem. Int. Ed2015，，13： | 1 |
| 15 | Wideband CMOS variable gain amplifier with decibel-linear gain control characteristic显示文摘This paper presents a wideband variable gain amplifier(VGA) featuring a decibel-linear gain control characteristic. The decibel-linear gain control function is realized using two VGA cells and a control signal converter. The bandwidth is extended by using cascode architecture together with active inductive load. To achieve small parasitic and low area,direct current(DC) coupling is adopted in the circuit while a DC offset cancellation(DCOC) circuit is introduced to cancel the DC offset. Fabricated in a 0.18 μm complementary metal oxide semiconductor(CMOS) process, the chip occupies an area of 0.53 mm×0.48 mm(including pads) and draws a total current of 9 mA from a 1.8 V supply. The measurement results show that the gain of the VGA varies from-40 dB to 18 dB while the control voltage varies from 0 to 1.8 V, resulting in a total gain control range of 58 dB. The 3 dB bandwidth of the VGA is larger than 260 MHz at maximum gain. | Dun Shubo Li Bin Shi Guochao Yang Geliang | 2019 | The Journal of China Universities of Posts and Telecommunications2019，26，1： | 1 |
| 16 | The Fourier regularization method for identifying the unknown source on Poisson equation显示文摘 | YANG Fan LI Dun - gang | 2010 | Int Journal of Math Analysis2010，4，28： | 1 |
| 17 | Distribution and biological action of obstatin in the rat 显示文摘 | Dun SL Bmiloiu GC Yang J | 2006 | J Endoerinol2006，191，2： | 1 |
| 18 | High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates显示文摘 | Wu LL Dunning KR Yang X | 2010 | Endocrinology2010，，： | 1 |
| 19 | Holographic storage scheme based on digital signal processing 显示文摘 | Kebin Jia Dapeng Yang Shubo Dun | 2003 | Chin Opt Lett2003，1，10： | 1 |
| 20 | Apelin-immunoreactivity in the rat hypothalamus and pituitary显示文摘 | Brailoiu GC Dun SL Yang J | 2002 | Neurosci Lett2002，327，3： | 1 |
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