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| 1 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘 | Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z | 2006 | 中国生物学文摘2006，20，8： | 30 |
| 2 | Insulin glargine versus NPH insulin therapy in Asian Type 2 diabetes patients显示文摘 | Pan, CY Sinnassamy, P Chung, KD Kim, KW | 2007 | 中国生物学文摘2007，21，11： | 17 |
| 3 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 4 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 5 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 6 | The transmembrane domain of TACE regulates protein ectodomain shedding显示文摘众多的膜蛋白质被变换酶的肿瘤坏死 factor-alpha 劈开(不作声) ,它引起他们的 ectodomains 的版本。ADAM (一个 disintegrin 和 metalloprotease 领域) 家庭成员,不作声包含谁的几个非催化的领域在流的 ectodomain 的角色还得充分被解决。这里,我们探索了 transmembrane 领域(TM ) 的功能由联合分子的工程和功能的分析不作声。一 TM 免费不作声被有约束力的多肽没能恢复转变生长 factor-alpha (TGF-alpha ) 流的 glycosylphosphatidylinositol (GPI ) 抛锚到血浆膜的构造,肿瘤坏死 factor-alpha (TNF-alpha ) 和在细胞缺乏的 L-selectin 内长不作声活动。有催乳激素受体或导出血小板的生长因素受体(PDGFR ) 的 TACE TM 的替换也导致了流的 TGF-alpha 的严重损失,但是没在 TNF-alpha 和 L-selectin 的劈开上有效果。在有 L-selectin 的 TGF-alpha 的 TM 的代替启用了由带催乳激素受体和 PDGFR 的 TM 的 TACE 异种流的 TGF-alpha。总起来说,我们的观察建议那个抛锚通过 TM 不作声到类脂化合物双性人层为许多底层的有效劈开被要求,并且氨基酸的顺序不作声 TM 可以在规章的特性起一个作用在之中不作声底层。 | Xiaojin Li Liliana Pére Zui Pan Huizhou Fan | 2007 | Cell Research2007，17，12： | 5 |
| 7 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 8 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 9 | FOUR NEW GLYCOSIDES, LIGUROBUSTOSIDES A, B, C AND D FROM LIGUSTRUM ROBUSTUM显示文摘FOURNEWGLYCOSIDES,LIGUROBUSTOSIDESA,B,CANDDFROMLIGUSTRUMROBUSTUM￥JunTIAN;HongJieZHANGandHanDongSUN.(Laboratoryofphytochemistr... | Tian, J Zhang, HJ Sun, HD Pan, LT Yao, P Chen, DY | 1996 | Chinese Chemical Letters1996，7，4： | 3 |
| 10 | TREATMENT AND RESOURSE REUSE OF INDUSTRIAL WASTEWATER FROM PRODUCTION PROCESS OF PHENYL ACETIC ACID显示文摘The effluent from phenyl acetic acid (PhCH2COOH) production process can betreated with NDA-999 macroporous polymeric adsorbent with about 100% removalefficiency of PhCH2COOK benzyl alcohol (PhCH2OH)and benzaldehyde (PhCHO) aswell as the decrease in Total Organic Carbon (TOC)from 4691mg/l to <300mg/L. 3. 7kgPhCH2COOH and 120kg NaCl will be recovered from per m3 wastewater and theadsorbent can be reused after being regenerated by NaOH aqueous solution andmethanol. Good economic, social and environmental results can be achieved with thismethod. | PAN Bingcai CHEN Jinlong ZHANG Quanxing WANG Yong(State Key Laboratory of Pollution Control & Resource Reuse, Department of EnvironmentalScience & Engineering, Nanjing University Nanjing 210093, P R. China) | 1999 | Chinese Journal of Reactive Polymers1999，8，1： | 3 |
| 11 | Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus显示文摘To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK- mutant were sequenced. Analysis of the tk gene sequence of TK mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All | Pan, ZS Zhang, CY Ding, JH Min, P | 2001 | Chinese Science Bulletin2001，46，23： | 2 |
| 12 | Molecular epidemiological studies on foot-and-mouth disease type O Tainwan viruses from the 1997 epidemic显示文摘 | Tsai C P Pan C H Liu M Y | 2000 | Vet Microbiol2000，74，3： | 2 |
| 13 | Modal analysis of magneto-electro-elastic plates using the state-vector approach显示文摘 | Chen J Y Chen H L Pan E Heyliger P R | 2007 | Journal of Sound and Vibration2007，304，： | 1 |
| 14 | A discrete artificial bee colony algorithm for the lot- streaming flow shop scheduling problem显示文摘 | PAN Q FATIH TASGETIREN M SUGANTHAN P N etal | 2011 | Information Sciences2011，181，12： | 1 |
| 15 | Selective hepatic vascular exclusion and Pringle maneuver:a comparative study in liver resection显示文摘 | ZHOU W P LI A J PAN Z Y | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 16 | MicroRNAs as oncogenes and tumor suppressors显示文摘 | Zhang B Pan X Cobb G P | 2007 | Dev Biol2007，302，1： | 1 |
| 17 | Thermal degradation ehemistry of alkyl quaternary ammonium montmorillonite 显示文摘 | XIE W GAO Z M PAN W P | 2001 | Chem Mater2001，13，9： | 1 |
| 18 | A Dif- ferential Evolution Algorithm with Self-Adapting Strategy and Control Parameters 显示文摘 | PAN Q K SUGANTHAN P N WANG L | 2011 | Computers and Operations Research2011，38，1： | 1 |
| 19 | The solid-state neck growth mechanisms in low energy laser sintering of gold nanoparticles: A molecular dynamics simulation study 显示文摘 | PAN H KO S H GRIGOROPOULOS C P | 2008 | Journal of Heat Transfer2008，130，09： | 1 |
| 20 | Influence of retrogression and re-aging treatment on corrosion behaviour of an A1-Zn-Mg-Cu alloy显示文摘 | XIAO Y P PAN Q L LI W B | 2011 | Materials& Design2011，32，4： | 1 |
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