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| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude显示文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude. | Lin-Jie Wei Chi Lin Xing-Sen Xue Guo-Dong Dun Jian-Bo Zhang Yan-Xiang Tong Jia-Xiong Wang Shi-Ji Yang Ling Wang Zhi Chen Hua Feng Gang Zhu | 2021 | Chinese Journal of Traumatology2021，24，6： | 11 |
| 3 | EMTP-type Program Realization of Krylov Subspace Based Model Reduction Methods for Large-Scale Active Distribution Network显示文摘Effective model reduction methods are required to deal with new challenges in active distribution network simulations that are on a large scale and have complicated structures.In the development of advanced electromagnetic transient simulation programs,automated model reduction plays an important role.This paper proposes an automated realization algorithm for the Krylov subspace based model reduction methods of an active distribution network with which the reduced model can be automatically established according to a given threshold of reduction error.The combined state-space nodal analysis framework is employed to apply the automated model reduction algorithm in popular EMTP-type simulation programs.Simulations are performed using PSCAD and a self-developed program to show the feasibility and validity of the proposed methods. | Chengshan Wang Hao Yu Peng Li Jianzhong Wu Chengdi Ding Guanyu Song Dun Lin Feng Xing | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 8 |
| 4 | Development of highly glyphosate-tolerant tobacco by coexpression of glyphosate acetyltransferase gat and EPSPS G2-aroA genes显示文摘The widely used herbicide glyphosate targets 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS).Glyphosate acetyltransferase(GAT)effectively detoxifies glyphosate by N-acetylation.With the aim of identifying a new strategy for development of glyphosate-tolerant crops,the plant expression vector pG2-GAT harboring gat and G2-aroA(encoding EPSPS)has been transformed into tobacco(Nicotiana tabacum)to develop novel plants with higher tolerance to glyphosate.Results from Southern and Western blotting analyses indicated that the target genes were integrated into tobacco chromosomes and expressed effectively at the protein level.Glyphosate tolerance was compared among transgenic tobacco plants containing gat,G2-aroA,or both genes.Plants containing both gat and G2-aroA genes were the most glyphosate-tolerant.This study has shown that a combination of different strategies may result in higher tolerance in transgenic crops,providing a new approach for development of glyphosate-tolerant crops. | Baoqing Dun Xujing Wang Wei Lu Ming Chen Wei Zhang Shuzhen Ping Zhixing Wang Baoming Zhang Min Lin | 2014 | The Crop Journal2014，2，Z1： | 4 |
| 5 | Unusual peroxidase activity of a myoglobin mutant with two distal histidines显示文摘由在精子鲸鱼肌球素(Mb ) 保留本国的远侧的 His64,第二远侧的 histidine 被变异的 Leu29 在 Mb 设计到 His29。L29H Mb 的结果的异种与野类型 Mb 的相比与积极 cooperativity 展出一项不平常的提高的 peroxidase 活动。有二合作远侧的 histidines 的新酶没在本国的 peroxidase 被发现,它强调合理蛋白质设计的创造。 | Wei Wei Guo Dun Wan Li Fu Liao Ying Wu Lin | 2012 | Chinese Chemical Letters2012，23，6： | 3 |
| 6 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 7 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 8 | Three Super Active Regions in the Descending Phase of Solar Cycle 23显示文摘We analyze the magnetic configurations of three super active regions,NOAA 10484, 10486 and 10488, observed by the Huairou Multi-Channel Solar Telescope (MCST) from 2003 October 18 to November 4. Many energetic phenomena,such as flares (including a X-28 flare) and coronal mass ejections (CMEs), occurred during this period. We think that strong shear and fast emergence of magnetic flux are the main causes of these events. The question is also of great interest why these dramatic eruptions occurred so close together in the descending phase of the solar cycle. | Hong-Qi Zhang, Xing-Ming Bao, Yin Zhang, Ji-Hong Liu, Shu-Dong Bao, Yuan-Yong Deng, Wei Li, Jie Chen, Jin-Ping Dun, Jiang-Tao Su, Juan Guo, Xiao-Fan Wang, Ke-Liang Hu, Gang-Hua Lin and Dong-Guang WangNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 | 2003 | Chinese Journal of Astronomy and Astrophysics2003，3，6： | 2 |
| 9 | Incorporating Trade into the Investment Development Path: A Case Study of Korea and Taiwan显示文摘 | John H. Dunning Chang-Su Kim Jyh-Der Lin | 2001 | Oxford Development Studies2001，，2： | 1 |
| 10 | Mortality risk in symptomatic patients with non-obstructive coronary artery disease:a prospective 2-center studv of 2583 patients undergoing 64-detector row coronary computed tomographic angiography显示文摘 | Lin FY Shaw LJ Dunning AM | 2011 | J Am Coll Cardiol2011，58，： | 1 |
| 11 | Mortality risk in symptomatic patients with nonobstructive coronary artery disease: a prospective 2-center study of 2, 583 patients undergoing 64-detector row coronary computed tomographic angiography显示文摘 | Lin FY Shaw LJ Dunning AM | 2011 | J Am Coil Cardiol2011，58，5： | 1 |
| 12 | Incremental prognostic significance of left ventricular dysfunction to coronary artery disease detection by 64-detector row coronary computed tomographic angiography for the prediction of all-cause mortality:Results from a two-centre study of 5330 patients显示文摘 | Min JK Lin FY Dunning AM | 2010 | European Heart Journal2010，31，10： | 1 |
| 13 | Age and sex related differ- ences in all-cause mortality risk based on coronary computed to- mography angiography findings results from the international multi-center confirm (coronary CT angiography evaluation for clinical outcomes: an international multicenter registry) of 23, 854 patients without known coronary artery disease 显示文摘 | Min JK Dunning A Lin FY | 2011 | J Am Coll Cardiol2011，58，： | 1 |
| 14 | Extent and severity ofcoronary artery disease by coronary CT angiography is associatedwith elevated left ventricular diastolic pressures and worsening dias-tolic function显示文摘 | Lin FY Zemedkun M Dunning A | 2013 | J Cardiovasc Comput Tomogr2013，7，5： | 1 |
| 15 | Incorporating Trade into the Investment Development Path: A Case Study of Korea and Taiwan显示文摘 | Dunning John H Chang-Su Kim and Jyh-Der Lin | 2001 | Oxford Development Studies2001，29，： | 1 |
| 16 | Age- and sex-related differences inall-cause mortality risk based on coronary computed tomographyangiography findings results from the International MulticenterCONfIRM ( Coronary CT Angiography Evaluationfor ClinicalOutcomes : An International Multicenter Registry) of 23 ,854patientswithout known coronary artery disease 显示文摘 | Min JK Dunning A lin fY | 2011 | J Am Coll Cardiol2011，58，8： | 1 |
| 17 | Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons显示文摘 | Goldie BJ Dun MD Lin M | 2014 | Nucleic Acids Res2014，42，14： | 1 |
| 18 | Activity-associated miRNA are packaged in Maplb-enriched exosomes released from depolarized neurons显示文摘 | Goldie B J Dun MD Lin M | 2014 | Nucleic Acids Res2014，42，14： | 1 |
| 19 | Mortality risk in symp- tomatic patients with nonobstructive coronary artery disease: a prospective 2-center study of 2,583 patients undergoing 64-de- tector row coronary computed tomographic angiography显示文摘 | Lin F Y Shaw L J Dunning A M | 2011 | J Am Coll Cardiol2011，58，5： | 1 |
| 20 | Incorporating Trade into the Investment Develop ment Path:a Case Study of Korea and Taiwan显示文摘 | Dunning Kim Lin | 2001 | Oxford Development Studies2001，29，2： | 1 |
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