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| 1 | 氧气与角膜接触镜配戴(英文)显示文摘全球大约有八千万人 (约占总人口的 1.5 % )在配戴角膜接触镜 ,镜片的透氧性及配戴角膜接触镜后角膜的获氧状态是保证配戴安全性和有效性的关键。角膜需要多种营养物质以保证其正常的代谢功能 ,氧气是其中是重要的部分 ,只有在充分氧供的状态下 ,角膜才能保持稳定的 78%的水合状态 ,保证角膜透明性。为了进一步了解氧气与角膜接触镜配戴的关系 ,本文着重对角膜接触镜所致的角膜缺氧的主要表现及角膜接触镜的透氧性能及其表达指标作一综述。配戴角膜接触镜后 ,角膜的氧供明显减少 ,特别在闭眼状态下氧供减少尤其明显 ,角膜接触镜引起的角膜缺氧变化主要表现为 :①角膜上皮 :角膜上皮水肿 ,即因细胞间隙中水液充盈而发生的微囊样水肿 ,水肿明显时会影响视力并使角膜的敏感性下降 ;②角膜基质 :角膜基质水肿达 5 %以上即可从裂隙灯检查中发现 ,主要表现为条纹或皱褶 ,长期慢性水肿会诱发角膜新生血管的发生 ,逐步发生角膜疤痕、屈光改变等一系列问题 ;③角膜内皮 :慢性角膜缺氧最终会导致角膜内皮细胞形态的改变 ,而且无法代偿。保持角膜功能的最低需氧量称为“临界氧” ,理想的角膜接触镜应该是通过该镜片后到达角膜面的氧供超过临界氧。角膜接触镜的透氧性能表达指标主要有 :透氧性 | 王建华 Desmond Fonn Renee Du Toit | 1999 | 眼视光学杂志1999，1，3： | 6 |
| 2 | 解析南非医疗“公私合营”机制显示文摘南非在建立和发展公平、高效、高质量的医疗保障体系的过程中,为公立医疗机构和私立医疗机构之间开展建设性的合作提供了相当大的空间。当决定是否应该在医疗体系中追求新的公私互动或公私合营机制之前,有必要对现有这种机制的功过是非、全民医疗体系的目标和已经取得的成绩进行认真评估。 | Japie Du Toit 张振安(编译) | 2005 | 中国卫生产业2005，，10： | 3 |
| 3 | Visual outcomes in patients with open globe injuries compared to predicted outcomes using the Ocular Trauma Scoring system显示文摘AIM: To determine the visual outcomes in adult patients who sustained open globe injuries and to determine whether the visual prognosis following an eye injury in an African setting differs from the predicted outcomes according to the Ocular Trauma Score(OTS)study. A secondary aim was to establish the evisceration rate for these injuries and assess how this form of intervention affected outcomes in comparison to the OTS.·METHODS: A prospective case series of all patients admitted with open globe injuries over a two-year(July2009 to June 2011) period. Injuries were scored using the OTS and the surgical intervention was recorded. The best corrected visual acuity at three months was regarded as visual outcome.· RESULTS: There were 249 open globe injuries, of which 169 patients(169 eyes) completed the 3-month follow-up. All patients underwent primary surgery, 175(70.3%) repairs, 61(24.5%) eviscerations and 13(5.2%)other procedures. Globe eviscerations were mainly done on OTS Category 1 cases, but outcomes in this category were not found to be different from OTS outcomes.Outcomes were significantly worse in Category 2, but when the entire distribution was tested, the differences were not statistically significant. The overall association between OTS outcomes and the final visual outcomes in this study was found to be a strong(P <0.005).· CONCLUSION: Reliable information regarding the expected outcomes of eye injuries will influence management decisions and patient expectations. The OTS is a valuable tool, the use of which has been validated in many parts of the world-it may also be a valid predictor in an African setting. | Nagib du Toit Hamza Mustak Colin Cook | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 4 | Conditioning with purine analogs leads to good engraftment rates of immunodepleted grafts for aplastic anemia显示文摘 | Novitzky N Thomas V du Toit C | 2013 | Biol Blood Marrow Transplant2013，19，4： | 1 |
| 5 | Establishing a Knowledge Management Programme for Competitive Advantage in an Enterprise显示文摘 | Ndlela L T Du Toit A S A | 2001 | International Journal of In-formation Management2001，，21： | 1 |
| 6 | Attitudes of ranchers to- wards African wild dogs Lycaon pictus: Conservation implications on private land 显示文摘 | Lindsey P A du Toit J T Mills M G L | 2005 | Biological Conservation2005，125，1： | 1 |
| 7 | No evidence for point mutation in codons 12, 13 and 61 of the ras gene in a high incidence area for esophageal and gastric cancer显示文摘 | Victor T Du Toit R Jordaan AM el at | 1990 | Cancer Res1990，50，16： | 1 |
| 8 | Robot motion planning in dynamic uncertain environments显示文摘 | Du Toit Burdick J W | 2012 | IEEE Transactions on Robot- ics2012，，： | 1 |
| 9 | Association of rheumatoid arthritis with HLA in three South African populations--whites, blacks and a population of mixed ancestry显示文摘 | Martell RW du Toit ED Kalla AA | 1989 | Afr Med J1989，76，5： | 1 |
| 10 | A knowledge management framework to grow innovation capability maturity显示文摘 | Esterhuizen D Schutte C Du Toit A | 2012 | SA Journal of Information Management2012，14，1： | 1 |
| 11 | Duodenal injuries: surgical management adapted to circumstances 显示文摘 | Jansen M Du Toit D F Warren B L | 2002 | Inju- ry2002，33，7： | 1 |
| 12 | Plantaricin D,a bacteriocin produced by Lactobacillus plantarum BFE 905 from ready-to-eat salad显示文摘 | FRANZC M Du TOIT M OLASUPO N A SCHILLILANGER U | 1988 | Lett Appl Microbiol1988，26，： | 1 |
| 13 | Design and performance of BNR activated sludge systems with flat sheet membranes for solid-liquid separation 显示文摘 | du Toit G J G Ramphao M C Parco V | 2007 | Water Sci Technol2007，56，6： | 1 |
| 14 | Anatomical and pathological considerations in percutaneous vertebroplasty and kyphoplasty:a reappraisal of the vertebral venous system显示文摘 | Groen RJ du Toit DF Phillips FM | 2004 | Spine (Phila Pa 1976)2004，29，13： | 1 |
| 15 | An in vitro evaluation of the cell toxicity of honey and silver dressings显示文摘 | Du Toit DF Page BJ | | 0，，09： | 1 |
| 16 | A macro-framework for successful development banks显示文摘 | Janine Thorne Charlotte du Toit | 2009 | Development Southern Africa2009，，5： | 1 |
| 17 | Endovascular aortic aneurysm repair by a multidisciplinary team:lessons learned and six-year clinical update显示文摘 | Du Toit DF Saaiman JA Carpenter JP | 2005 | Cardiovasc J S Afr2005，16，1： | 1 |
| 18 | Surgical treatment of comminuted, displaced fractures of the greater tuberosity of the proxi- mal humerus:a new technique of double-row suture-anchor fixation and long-term results显示文摘 | Bhatia DN van Rooyen Ks du Toit DF | 2006 | Injury2006，37，10： | 1 |
| 19 | Autoantibodies to the high-affinity IgE receptor in children with chronic urticaia 显示文摘 | Du Toit G Prescott R Lawrence P el al | 2006 | Ann Allergy Asthma Immunol2006，96，2： | 1 |
| 20 | Duodenal injuries:surgical management adapted to circumstances显示文摘 | Jansen M Du Toit DF Warren BL | 2002 | Injury2002，33，7： | 1 |
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