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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 4 | Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity显示文摘 | Ma Z Wei X Fontanilla C Noelker C Dodel R Hampel H Du Y | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | Very delayed infarction after mild focal cerebral ischemia:a role for apoptosis显示文摘 | Du C Hu R Csernansky CA | | 0，，： | 2 |
| 6 | Safety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience显示文摘 | Audrey Coilly Bruno Roche Jér?me Dumortier Vincent Leroy Danielle Botta-Fridlund Sylvie Radenne Georges-Philippe Pageaux Si-Nafaa Si-Ahmed Olivier Guillaud Teresa Maria Antonini Stéphanie Ha?m-Boukobza Anne-Marie Roque-Afonso Didier Samuel Jean-Charles Du | 2014 | Journal of Hepatology2014，，1： | 2 |
| 7 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 8 | Preparation and charac- terization of EVOH/PVP membranes via thermally induced phase separation显示文摘 | Lv R Zhou J Du Q G | 2006 | J Membr Sci2006，281，： | 1 |
| 9 | miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells 显示文摘 | Xia L Zhang D Du R | 2008 | Int J Cancer2008，123，2： | 1 |
| 10 | Tanshinone Ⅱ A protects cardiac myoeytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Du J Pi R Chen J Liu P | 2007 | Eur J Pharmacol2007，568，13： | 1 |
| 11 | Human trophobasts recuited T lympho-cytes and monocytes into deciduas by secretion of chemokine CXCL 16 and interaction with CXCR 6 in the first-trimester pregnancy 显示文摘 | Huang Y Zhu X Y Du M R | 2008 | J Immunol2008，180，4： | 1 |
| 12 | Transplantation of retinal cells显示文摘 | Gouras P Lopez R Du J | 1990 | Neuro Ophthalmol1990，10，： | 1 |
| 13 | The natural history of in- tracranial cavernous malformations显示文摘 | Gross BA Lin N Du R | 2011 | Neurosurg Focus2011，30，6： | 1 |
| 14 | Structural investigations of Fe-Ga alloys: Phase relations and magnetostrictive behavior 显示文摘 | XING Q DU Y MCQUEENEY R J LOGRASSO T A | 2008 | Acta Materialia2008，56，16： | 1 |
| 15 | Nanotube Networks in Polymer Nanocomposites: Rheology and Electrical Conductivity显示文摘 | Du Fangming Scogna R C Zhou W | 2004 | Macromolecules2004，37，24： | 1 |
| 16 | Pirfenidone: significant treatment effects in idiopathic pulmonary fibrosis 显示文摘 | Hilberg O Simonsen U du Bois R | 2012 | Clin RespirJ2012，6，3： | 1 |
| 17 | A study on the precision of mechanical watch movement with Tourbillon 显示文摘 | Gu Xu P H Ko R Du | 2011 | Journal of Sound and Vibra- tion2011，330，16： | 1 |
| 18 | Coordination of two-echelon supply chain usi:ng wholesale price discount and credit option显示文摘 | Du R | 2011 | Int J Production Economies2011，143，2： | 1 |
| 19 | Antiviral flavonoids from the root bark of Morus alba L 显示文摘 | Du J He Z D Jiang R W | 2003 | Phytochemistry2003，62，8： | 1 |
| 20 | Role of autophagy in angiogenesis in aortic endothelial cells显示文摘 | Du J Teng R J Guan T | 2012 | Am J Physiol Cell Physiol2012，302，2： | 1 |
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