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| 1 | Directional hydraulic fracturing to control hard-roof rockburst in coal mines显示文摘Hard roof is the main factor that induces rock-burst.In view of the present obvious weakness of control measures for hard roof rockburst in domestic collieries,the mechanism and field application of directional hydraulic fracturing technology for rock-burst prevention have been investigated in this paper using theoretical analysis and numerical simulation.The results show that the weighting span of the main roof and the released kinetic energy as well as the total elastic energy decreased greatly after the directional fracturing of hard roof with the mining progression,thereby reducing the rockburst hazard degree to coal body.The directional hydraulic fracturing technology was carried out in 6305 working face of Jisan Coal Mine to prevent rockburst.Field practices have proved that this technology is much simpler and safer to operate with better prevention effect compared with blasting.By optimizing the operation procedures and developing a new technology of automated high-pressure delivery pipe,the maximum fracturing radius now reaches more than 9 m and the borehole depth exceeds 20 m.Additionally,drilling cutting method was applied to monitor the stress of the coal mass before and after the fracturing,and the drill cuttings dropped significantly which indicates that the burst prevention effect of directional hydraulic fracturing technology is very remarkable.The research results of this paper have laid a theoretical and practical foundation for the widespread application of the directional hydraulic fracturing technology in China. | Fan Jun Dou Linming He Hu Du Taotao Zhang Shibin Gui Bing Sun Xinglin | 2012 | International Journal of Mining Science and Technology2012，22，2： | 28 |
| 2 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 3 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 4 | Are humic substances soil microbial residues or unique synthesized compounds?A perspective on their distinctiveness显示文摘Humic substances(HS),which are defined as a series of highly acidic,relatively high-molecular-weight,and yellow to black colored substances formed during the decay and transformation of plant and microbial remains,ubiquitously occur in nature.Humic substances represent the largest stable organic carbon pool in terrestrial environments and are the central characteristic of the soil.However,the validity of the HS concept and the justification of their extraction procedure have been recently debated.Here,we argue that the traditional humic paradigm is still relevant.Humic substances are distinctive and complex because the extracted HS formed during the humification are chemically distinct from their precursors and are heterogeneous among soils.By reviewing the concept,formation pathways,and stabilization of HS,we propose that the key question facing soil scientists is whether HS are soil microbial residues or unique synthesized compounds.Without revealing the distinctiveness of HS,it is impossible to address this question,as the structure,composition,and reactivity of HS are still poorly known owing to the heterogeneity and geographical variability of HS and the limits of the currently available analytical techniques.In our view,the distinctiveness of HS is fundamental to the soil,and thus further studies should be focused on revealing the distinctiveness of HS and explaining why HS hold this distinctiveness. | Sen DOU Jun SHAN Xiangyun SONG Rui CAO Meng WU Chenglin LI Song GUAN | 2020 | Pedosphere2020，30，2： | 12 |
| 5 | The coalbed methane production potential method for optimization of wells location selection显示文摘 | Feng-Ke DOU Yong-Shang KANG Shao-Feng QIN De-Lei MAO Jun HAN | 2013 | Journal of Coal Science & Engineering(China)2013，19，2： | 11 |
| 6 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 7 | F-structure model of overlying strata for dynamic disaster prevention in coal mine显示文摘The rupture and movement scope of overlying strata upon the longwall mining face increased sharply as the exploitation scale and degree growing recently,and the spatial structure formed by fractured strata became much more complex.The overlying strata above the working face and adjacent gobs would affect each other and move cooperatively because small pillar can hardly separate the connection of overlying strata between two workfaces,which leads to mining seismicity in the gob and induces rockburst disaster that named spatial structure instability rockburst in this paper.Based on the key stratum theory,the F-structure model was established to describe the overlying strata characteristic and rockburst mechanism of workface with one side of gob and the other side un-mined solid coal seam.The results show that F-structure in the gob will re-active and loss stability under the influence of neighboring mining,and fracture and shear slipping in the process of instability is the mechanism of the seismicity in the gob.The F-structure was divided into two categories that short-arm F and long-arm F structure based on the state of strata above the gob.We studied the underground pressure rules of different F-structure and instability mechanism,thus provide the guide for prevention and control of the F-structure spatial instability rockburst.The micro-seismic system is used for on-site monitoring and researching the distribution rules of seismic events,the results confrmed the existence and correct of F-spatial structure.At last specialized methods for prevention seismicity and rockburst induced by F-structure instability are proposed and applied in Huating Coal Mine. | Mu Zonglong Dou Linming He Hu Fan Jun | 2013 | International Journal of Mining Science and Technology2013，23，4： | 8 |
| 8 | Two-year clinical outcome after successful implantation of drug-eluting and bare metal stents in diabetic patients: results from a real-world single center registry显示文摘背景 Drug-eluting stents (DES ) 由戏剧性地改善革命化了 interventional 心病学的地临床并且 angiographic 结果。有糖尿病 mellitus (DM ) 的病人在经皮的冠的干预(一种总线标准) 以后与不利临床的结果的增加的风险被联系。在糖尿病的病人的 DES 和赤裸的金属 stent (BMS ) 的功效和安全的可得到的信息从 2004 年 4 月仍然是 scarce.Methods 到 2006 年 10 月,有糖尿病的 1565 个病人,成功地在中国北京在 Fu Wai 医院经历了选任的 stenting,在这研究被注册。所有注册病人被分到一个药 eluting stent 组和一个赤裸的金属 stent 组。我们获得了后续数据:死亡,心肌的梗塞(MI ) ,血栓,目标损害 revascularization (TLR ) ,和在 30 天和 12 和 24 个月的目标容器 revascularization (TVR ) 由学术研究协会定义弧) 。我们计算了并且比较所有 unadjusted 在二个组的各种各样的不利事件的累积频率。考克斯与倾向分数调整的比例危险的模型被用来在 24 个月在 24 months.Results 估计所有结果措施的相对风险,在二的定义 stent 血栓组织的所有弧是类似的;在 30 天,更明确的血栓在 BES 组被发现(0.08% 对 0.81% , P=0.016 ) 。与 DES 对待的病人显示出 TLR 的重要更低的风险(3.88% 对 10.89% ;危险比率(HR ) 0.159 (95% CI:0.151-0.444 ) , P < 0.001 ) , TVR (5.48% 对 11.69% ;HR 0.383 (95% CI:0.232-0.633 ) , P < 0.001 ) ,并且任何 revascularization (12.47% 对 18.55% ;HR 0.555 (95% CI:0.370-0.831 ) , P=0.0004 ) 在 24 个月。没有重要差别以在当代的社会的大、糖尿病的人口的所有原因死亡, MI,和所有原因 mortality/MI.Conclusions 是明显的, DES 的使用在 TLR, TVR,和任何 revascularization 的风险与长期的重要减小被联系。在在在有在 24 月的后续的糖尿病的病人的 DES 和 BMS 之间的所有原因死亡, MI,和血栓没有重要差别。 | DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun GAO Run-lin | 2009 | Chinese Medical Journal2009，，6： | 7 |
| 9 | Phase equilibria for the pseudo-ternary system(NaCl+Na2SO4+H2O)of coal gasification wastewater at T=(268.15 to 373.15)K显示文摘The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal solution saturation method. The equilibrium solids were also investigated by the Schreinemaker's method of wet residues and X-ray powder diffraction(XRD). According to the experimental data, the phase diagrams were determined. It was found that there was no significant solubility difference on the Na Cl-rich side between the ternary system(Na Cl + Na_2SO_4+ H_2O) in coal gasification wastewater and in pure water. However, the solubility on the Na_2SO_4-rich side of coal gasification wastewater was apparently higher than that of pure water. The increase in the solubility of Na_2SO_4 was most likely caused by the effects of other impurities apart from Na Cl and Na_2SO_4 in coal gasification wastewater. The measured data and phase equilibrium diagrams can provide fundamental basis for salt recovery in coal gasification wastewater. | Haijiao Lu Jingkang Wang Jun Yu Yuefeng Wu Ting Wang Ying Bao Dou Ma Hongxun Hao | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 7 |
| 10 | An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital显示文摘 | Jun Li Ming-Xiang Zou Hai-Chen Wang Qing-Ya Dou Yong-Mei Hu Qun Yan Wen-En Liu | 2016 | Chinese Medical Journal2016，，17： | 6 |
| 11 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor显示文摘Embryo implantation is a crucial step in mammalian reproduction.However,little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation.Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation.Both transient and prolonged transgenic expression of miR-181 led to impaired implantation,which can be rescued by exogenous administration of leukemia inhibitory factor(LIF).Mechanistically,miR-181 is able to directly target LIF and downregulate LIF expression,thereby inhibiting embryo implantation.We also show that miR-181 expression is regu-lated by the transcriptional factor Emx2,and the Emx2–miR-181 axis plays an importantrole in regulating embryo implantation.Taken together,these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF,and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. | Bo Chu Liangwen Zhong Shuang Dou Jun Wang Jianmin Li Mingwei Wang Qinghua Shi Yide Mei Mian Wu | 2015 | Journal of Molecular Cell Biology2015，7，1： | 5 |
| 12 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 13 | Conjugated polymers containing B←N unit as electron acceptors for all-polymer solar cells显示文摘Polymer electron acceptors are the key materials in all-polymer solar cells(all-PSCs).In this review,we focused on introducing the principle of boron-nitrogen coordination bond(B←N),and summarizing our recent research on polymer electron acceptors containing B←N unit for efficient all-PSC devices.Two approaches have been reported to design polymer electron acceptors using B←N unit.One is to replace a C-C unit by a B←N unit in conjugated polymers to transform a polymer electron donor to a polymer electron acceptor.The other approach is to construct novel electron-deficient building block based on B←N unit for polymer electron acceptors.The polymer electron acceptors containing B←N unit showed tunable lowest unoccupied molecular orbital(LUMO) energy levels and exhibited excellent all-PSC device performance with power conversion efficiency of exceeding6%.These results indicate that organic boron chemistry is a new toolbox to develop functional polymer materials for optoelectronic device applications. | Chuandong Dou Jun Liu Lixiang Wang | 2017 | Science China Chemistry2017，60，4： | 5 |
| 14 | Strategies for improving the lithium-storage performance of 2D nanomaterials显示文摘2D nanomaterials, including graphene, transition metal oxide(TMO) nanosheets, transition metal dichalcogenide(TMD) nanosheets, etc., have offered an appealing and unprecedented opportunity for the development of high-performance electrode materials for lithium-ion batteries(LIBs). Although significant progress has been made on 2D nanomaterials for LIB applications in the recent years, some major challenges still exist for the direct use of these sheet-like nanomaterials, such as their serious self-agglomerating tendency during electrode fabrication and low conductivity as well as the large volume changes over repeated charging–discharging cycles for most TMOs/TMDs, which have resulted in large irreversible capacity, low initial Coulombic efficiency and fast capacity fading. To address these issues,considerable progress has been made in the exploitation of 2D nanosheets for enhanced lithium storage. In this review, we intend to summarize the recent progress on the strategies for enhancing the lithium-storage performance of 2D nanomaterials, including hybridization with conductive materials, surface/edge functionalization and structural optimization. These strategies for manipulating the structures and properties of 2D nanomaterials are expected to meet the grand challenges for advanced nanomaterials in clean energy applications and thus provide access to exciting materials for achieving high-performance next-generation energy-storage devices. | Jun Mei Yuanwen Zhang Ting Liao Ziqi Sun Shi Xue Dou | 2018 | National Science Review2018，5，3： | 5 |
| 15 | Inhibitory effects of EGFR antisense oligodeoxynucleotide in human colorectal cancer cell line显示文摘INTRODUCTIONEpidermal-growth-factor receptor(EGFR) is apolypeptide with 1186 amino acids,which binds toEGF family growth factors.Two major naturalligands in the family interact with EGFR:one isEGF,the other is transforming growth factor-α(TGF-α).When EGF or TGF-α,binds to EGFR,tyrosine kinase activity is induced which in turntriggers a series of events regulating the cellgrowth.The importance of EGFR in growthregulating pathways was confirmed by the fact | Yong He Jun Zhou Jin Sheng Wu Ke Feng Dou | 2000 | World Journal of Gastroenterology2000，6，5： | 5 |
| 16 | Clinical and angiographic characteristics of premenopausal women with coronary artery disease显示文摘当中年的 men.It 的疾病广泛地被接受,背景冠的动脉疾病( CAD )通常被考虑因为荷尔蒙 protection.Based ,为绝经前的女人的 CAD 的风险是低的,没有足够的 concern.Even nowthere ,更绝经前的女人受不了咽峡炎和心肌的梗塞,这仍然是有限的详细数据为了描述绝经前的 CAD patients.This 的 characteristicsmechanism 和预后,文章瞄准了到分析临床所有 P < 0.05 )我们在绝经前的 CAD 发现了单个容器的更多的经常的参与的 .Although (43.2%对 26.9%P=0 ),并且三倍的容器在绝经后( 56-60 岁) CAD 病人(33.8%对 20.4%P=0 )更严重的损害(90%)在留给主要(2.9%对1.1%, P=0.048 )并且近似左前面的下降动脉(男孩)(28.2%对 16.6%P=0 )在绝经前的 CAD ,组是有胸不快的绝经前的女人总是被发现把明显的 atherosclerosismore 使倾向了被定位的 found. | DOU Ke-fei XU Bo YANG Yue-jin Lü Rong QIU Hong YANG Wei-xian MU Zhao-wei GAO Run-lin GAO Zhan CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen LIU Hai-bo WU Yong-jian CHEN Jue YAO Min YOU Shi-jie YUAN Jin-qing DAI Jun | 2008 | Chinese Medical Journal2008，，23： | 5 |
| 17 | Computer Controlled Polishing of the Off-axis Aspheric Mirrors显示文摘In this paper, the manufacturing and testing procedures to make large off-axis aspherical mirrors are presented. The difficulties in polishing and testing for both circular aperture and rectangular aperture mirrors are previewed, and a possible solution is given. The two mirrors have been polished by means of CCOS, and the final accuracy is 25nm rms for 770mm×210mm rectangular mirror and 20nm rms for φ600mm circular mirror. These results just meet the optical tolerances specified by the designer, and the manufacturing and testing procedures presented here show good ability to make the large off-axis aspherical mirrors. | ZHANG Xue jun,WENG Zhi cheng,ZHANG Zhong yu, WANG Quan dou,ZHANG Feng (Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130022, China) | 2001 | 光学精密工程2001，9，5： | 4 |
| 18 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 19 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 20 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
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