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| 1 | Cycloastragenol upregulates SIRT1 expression,attenuates apoptosis and suppresses neuroinflammation after brain ischemia显示文摘Cycloastragenol(CAG)is the active form of astragaloside V isolated from Astragalus Radix,which displays multiple pharmacological effects.Silent information regulator 1(SIRT1),a classll histone deacetylase,has been shown to play an important role in neuroprotection against cerebral ischemia.In this study,we investigated whether CAG protected against ischemic brain injury and,if so,whether the beneficial effects were associated with the regulation of SIRT1 in the ischemic brain.Mice were subjected to 45 min of middle cerebral artery occlusion(MCAO)followed by reperfusion.CAG(5,10,20 mg/kg)was injected intraperitoneally at the onset of reperfusion,12h later and then twice daily for up to three days.CAG dose-dependently reduced brain infarct volume,significantly ameliorated functional deficits,and prevented neuronal cell oss in MCAO mice.Meanwhile,CAG signicantly reduced matrix metalloproteinase-9 activity,prevented tight junction degradation and subsequently ameliorated blood-brain barier disruption.Moreover,CAG significantly upregulated SIRT1 expression in the ischemic brain but did not directly activate its enzymatic activity.Concomitant with SIRT1 upregulation,CAG reduced p53 acetylation and the ratio of Bax to Bcl-2 in the ischemic brain.CAG also inhibited NF-κB p65 nuclear translocation.As a result,CAG suppressed the mRNA expression of pro-inflammatory cytokines,including TNF-α and IL-1β,and inhibited the activation of microglia and astrocytes in the ischemic brain.Our findings suggest that CAG is neuroprotective against ischemic brain injury in mice and that its beneficial effect may involve SIRT1 upregulation and the inhibition of apoptosis and neuroinflammation in the ischemic brain. | Man Li Shichun Li Bao-kai Dou Yving-xiang Zou Hao-zhen Han Dong-xiang Liu Zunji Ke Zhi-fei Wang | 2020 | Acta Pharmacologica Sinica2020，41，8： | 22 |
| 2 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 3 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 4 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 5 | Microstructure of β-Dicalcium Silicate after Accelerated Carbonation显示文摘The present work presents the microstructure of β-Ca_2SiO_4(β-C_2S) after accelerated carbonation. The synthesis procedure of β-C_2S was examined first, and the crystalline and amorphous structure, the distribution and the pore structure of β-C_2S carbonation products were also determined by X-ray diffraction(XRD) quantitative analysis, simultaneous thermal analyzer(TG/DTA), Fourier transform-infrared spectroscopy(FT-IR), high resolution ^(29)Si magic angle spinning nuclear magnetic resonance(^(29)Si NMR), N_2-sorption techniques, and scanning electron microscopy(SEM), respectively. Test results indicate that carbonation products are dramatically formed in the initial 2 h. The main carbonation products are crystalline calcite and amorphous three-dimensional network silica gels, which contain nanometer-sized pores. The calcite, silica gels and un-carbonated β-C_2S are distributed hierarchically. | 刘松辉 WANG Junjie 张海波 GUAN Xuemao QIU Man DOU Zhenzhen | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 6 | Computerized errorless learning-based memory rehabilitation for Chinese patients with brain injury: a preliminary quaY'i-experimental clinical design study显示文摘 | Dou Z L Man D W Ou H N | 2006 | Brain Inj2006，20，3： | 1 |
| 7 | Computerized errorless learning-based memory rehabilitation for Chinese patients with brain injury:a prelimi- nary quasi-experimental clinical design study 显示文摘 | Dou ZL Man DW Ou HN at al | 2006 | Brain Inj2006，20，3： | 1 |
| 8 | Computerized errorless learningbased memory rehabilitation for Chinese patients with brain injury:a preliminary guasi-experimental clinical design study 显示文摘 | Dou ZL Man DW Ou HN | 2006 | Brain Inj2006，20，： | 1 |
| 9 | Computerized errorless learning-based memory rehabilitation for Chinese patients with brain injury: a preliminary quasi-experimental elinieal design study显示文摘 | Dou ZL Man DW Ou HN | 2006 | Brain Inj2006，20，3： | 1 |
| 10 | Community - based cognitive rehabilition service for population with traumatic brain injury in China显示文摘 | Dou ZL Man DWK Tam SF | 2004 | Int J Rehabil Res2004，27，： | 1 |
| 11 | Minor Compounds from Fungus Ganoderma cochlear显示文摘Objective To study the chemical constituents of the fungus Ganoderma cochlear. Methods The compounds were isolated by using MCI gel CHP 20 P, Sephadex LH-20, RP-18 column chromatography, and preparative TLC. The structures were identified by means of spectroscopic methods. Results Two phenolic normeroterpenoid and meroterpenoid, cochlearols C and D(1 and 2), together with six benzene derivatives, 3-methoxy-4-hydroxy-phenylethanol(3), 4-hydroxyacetophenone(4), p-hydroxycinnamic methyl ester(5), 2-methoxy-4-hydroxybenzaldehyde(6), 4-hydroxy-3-methoxy benzoic acid(7), and 2-hydroxy-5-ethoxybenzoic acid(8), were isolated from the fruiting bodies of Ganoderma cochlear. Conclusion Compounds 1 and 2 are new phenolic normeroterpenoid and meroterpenoid, respectively. | Man Dou Rong-tao Li Yong-xian Cheng | 2016 | Chinese Herbal Medicines2016，8，1： | 1 |
| 12 | SYNTHESIS AND STRUCTURE OF Cu(Ⅱ)COMPLEXES BY OXIDATIVE ADDITION OF DIBENZOYL PEROXIDE ON METALLIC COPPER显示文摘Dibenzoyl peroxide undergoes oxidative addition on metallic copperpowder with 2,2′-bipyridine(or imidazole)in a mixed solvent(methanol andtetrahydrofuran),and affords the Cu(Ⅱ)complexes-[Cu(Ce(C6H5COO)2(2,2’-bipy)]H2O(1)and[Cu(C6H5COO)2(C3H4N2)2](2).The structure was solved by direct methodsand Fourier synthesis.C24H20N2O5Cu (1),Mr=479.78,space group P2(1)/c,a=6.986(7),b=18.833(I),c=17.021(3),α=γ=90°,Z=4,V=2218.13,Dc=1.443g/cm\+3,R=0.055Rw=0.062.Complex(2),C20H18N4O4Cu(2),Mr=441.74,space group P2(1)/n,a=8.699(4),b=9.840(6),c=12.399(5),α=γ=90°,β=100.8°,Z=4,V=1010.93,Dc=1.654g/cm\+3,R=0.055,Rw=0.062. | Rui Na YANG Dong Mei WANG Dou Man JIN Henan Institute of Chemistry,Zhengzhou 450003Hua Qin WANG Yao YANG Nanjing University,Nanjing 210008 | 1993 | Chinese Chemical Letters1993，4，2： | 0 |
| 13 | A NOVEL SYNTHETIC METHOD AND STRUCTURE OF TETRAKIS(BENZOATE)BIS(TRIPHENYLPHOSPHINE OXIDE)DICOPPER(II).OXIDATIVE ADDITION OF DIBENZOYL ON METALLIC COPPER显示文摘Dibenzoyl peroxide undergoes oxidative addition on metalliccopper with triphenylphosphine in a mixed solvent(acetone,dichloromethaneand trichloromethane),and affords the binuclear copper complex(Cu(C6H5COO)2(OPPh3))2.Crystals are monoclinic,space group A2/a,withcell parameters,a=24.337(3),b=10.566(1),c=21.579(2),β= 93.18(1)°,V=5540(1)3,Z=4,R=0.042,and Rw=0.044 for 5872 observed reflections.Each copper ion is coordinated by four bridging benzoato ligands and onetriphenylphosphine oxide group to form binuclear complexes. | Rui Na YANG Bao Yu XUE and Dou Man JIN Henan Institute of Chemistry,Zhengzhou 450003 KOZO KOZAWA and TOKIKO UCHIDA Science University of Tokyo,Noda,Chiba 278,Japan | 1992 | Chinese Chemical Letters1992，3，9： | 0 |
| 14 | PRELIMINARY STUDIES ON THE SYNTHESIS AND CHARACTERIZATION OF OXY-AND THIO-DIACETIC ACID HYDRAZITION AND THEIR FIRST-ROW TRANSITION METAL COMPLEXES显示文摘It has been made certain that thio-and oxy-diacetic acid hydrazidesare potential anticancer compounds.However,their ability to formcomplexes with transition metals and the properties of the complexes thusformed have not been studied.Employing a new potential anticancer ligand1,2-bis(thioacetic acid hydrazide)ethane prepared in our lab,along withligands oxydiacetic hydrazide and 1,2-bis(oxyacetic acid hydrazide)ethane,a series of 11 new first-row transition metal(M=Zn2+,Cu2+,Co2+,Ni2+)complexes with each of the above three ligands have been synthesizedand characterized by means of elemental analyses,IR,TG and X-raypowder diffraction. | Bao Yu XUE Zhen Feng Xi Si Guo YUAN Dou Man JIN Henan Institute of Chemistry,Zhengzhou 450003 | 1991 | Chinese Chemical Letters1991，2，9： | 0 |
| 15 | SYNTHESIS AND CHARACTERIZATION OF A NOVEL BONDING TRINUCLEAR(Mo/Fe/Mo) COMPLEX (MoCl_4)_2·dppf显示文摘By the reaction of bidentate ligand 1,1’-bis(diphenylphosphino)-ferrocene (dppf) with MoCl4(CH3CN)2, a novel bonding type complex (MoCl4)2· (dppf) was synthesized and characterized by elemental analyses, 31p-NMR, IR and electronic spectra, TG and ICP-AES. Structure of the title complex was proposed. | Zhen Feng XI Rui Na YANG Dou Man JIN~* Henan Institute of Chemistry, Zhengzhou 450003 Jin Chun WU Depart. of Chem. Engin., Zhengzhou Inst. of Tech., Zhengzhou 450002 | 1992 | Chinese Chemical Letters1992，3，10： | 0 |
| 16 | Sex differences in outcomes of total hip arthroplasty for the treatment of ankylosing spondylitis显示文摘To the Editor:Ankylosing spondylitis(AS)has always been viewed as a male-dominated disease with previous studies showing a male-female ratio of approximately 3:1.However,more recent surveys have shown increasing[1]homogeneity in gender prevalence.1 Female patients with AS tend to have a longer diagnosis delay compared with male patients.AS patients with delayed diagnosis displayed worse outcomes in disease activity,function,spinal mobility,and radiographic damage. | Liang Zhang Hong-Chao Li Si-Liang Man Tao Bian Yong Dou Wei Liu Yi-Xin Zhou | 2021 | Chinese Medical Journal2021，，21： | 0 |
| 17 | SYNTHESIS AND CHARACTERIZATION OF ZEROVALENT PALLADIUM COMPLEXES显示文摘A series of nine Pd(0)complexes(L)Pd(L’)[L=bis(diphenylphosphino)methane(dppm),1,2-bis(diphenylphosphino)ethane(dppe),and 1,1’-bis(diphenyl-phosphino)ferrocene(dppf),respectively;L=dibenzylideneacetone(dba),2,3,5,6-tetrachloro-1.4-benzoquinone(q)and 2,3-dichloro-1,4-naphthoquinone(nq)]were synthesized and characterized by means of elemental analyses,IR,UV,1H-NMR and31P-NMR spectra.The redox wave peak potentials of the ferrocenylgroup of complexes with dppf were measured by using CV method.Results showedthat all the diphosphorus ligands behaved as chelating bidentate ligand anddba,q,nq were coordinated to the Pd(0)atom through their C=C moieties,nottheir carbonyl ones.Analytical data also showed that there were interactionsbetween the two different ligands in each complex. | Zhen Feng XI Rui Na YANG Dou Man JIN | 1991 | Chinese Chemical Letters1991，2，4： | 0 |
| 18 | AN EASY ROUTE TO SYNTHESIZE COPPER(I) COMPLEXES Cu_2(Ph_2PCH_2PPh_2)_2(NO_a)_2 AND Cu(Ph_2PCH_2CH_2PPh_2)(NO_a). THEIR CHARACTERIZATION AND ELECTROCHEMISTRY显示文摘Binuclear Cu(Ⅰ) complex [Cu(dppm)(NO3)]2 (dppm=Ph2PCH2PPh2) and mononuclear Cu(Ⅰ) complex [Cu(dppe)(NO3)] (dppe=Ph2PCH2CH2PPh2) have been synthesized by the ligand-reduction reaction of cupric nitrate with dppm and dppe in methanol and characterized by means of ICP, elemental analyses, molecular weight determination, TG, 31P-NMR, IR and Raman spectra; their electronic conductivities and CV waves have also been measured. Results show that dppm coordinates to the Cu(Ⅰ) atoms as a bridging bidentate ligand and dppe as a chelating bidentate ligand, (NO3)-1 behaves as a chelating bidentate ligand in both of the newly prepared complexes. | Zhen Feng XI and Dou Man JIN Henan Institute of Chemistry, Zhengzhou 450003 | 1993 | Chinese Chemical Letters1993，4，1： | 0 |
| 19 | PREPARATION, CHARACTERIZATION AND ELECTROCHEMISTRY OF BINUCLEAR COPPER(I) COMPLEXES Cu_2(dppm)Cl_2 AND Cu_2(dppe)Cl_2显示文摘Two binuclear copper(I) complexes with novel structures and novel bonding,Cu2(Ph2PCH2PPh2)Cl2 (Ph2PCH2PPh2=dppm) and Cu2(Ph2P-CH2CH2PPh2)Cl2 (Ph2PCH2CH2PPh2=dppe), were prepared and characterized through elemental analyses, ICP, IR(4000-200 cm-1, CsI disc.), 31P-NMR spectra. Their electronic conductivities, oxidation and reduction potentials were measured. Preliminary studies show that both of the two complexes have chlorobridging and phosphorus-bridging structures. | Zhen Feng XI and Dou Man JIN Henan Institute of Chemistry, zhengzhou 450003 Jin Chun WU Zhengzhou Institute of Technology, Zhengzhou 450002 | 1993 | Chinese Chemical Letters1993，4，1： | 0 |
| 20 | STUDY ON BINUCLEAR COPPER(I)COMPLEXES III.SYNTHESIS,CHARACTERIZATION AND ELECTROCHEMISTRY OF DICHLORO-TRIS(4-VINYLPYRIDINE)-DICOPPER(I)COMPLEX显示文摘Recent years,many novel complexes have been prepared by usinghetero-bidentate ligands.However,complexes with such ligands as 4-vinylpyridinewhich has two different coordinating sites have not been reported,and only a fewcomplexes of Cu(I)have been published1-3.The title complex Cu2(C5H4N·CH=CH2)3Clwas prepared and characterized by elemental analyses,ICP,IR,and electronicspectra.Its conductivity,oxidation potential and reduction potential weremeasured. | Zhen Feng XI Rui Na YANG Dou Man JIN Henan Institute of Chemistry,Zhengzhou 450003 | 1990 | Chinese Chemical Letters1990，1，2： | 0 |
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