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| 1 | Quantitative Evaluation of Pain with Pain Index Extractecl from Electroencephalogram显示文摘 | Jian-Xiong An Yong Wang Doris K Cope John P Williams | 2017 | Chinese Medical Journal2017，，16： | 13 |
| 2 | Thunderclap Headache Caused by an Inadvertent Epidural Puncture During Oxygen-ozone Therapy for Patient with Cervical Disc Herniation显示文摘To the Editor: A 54-year-old woman with no significant history of a headache or hypertension underwent epidural oxygen-ozone injection at a concentration of 30 μg/ml (3 ml) for cervical disc herniation at cervical vertebra (C6-C7) level.Throughout the procedure, the routine monitorings of blood pressure, heart rate, and blood oxygen saturation were performed.One minute following the end of the injection, the patient developed a high-intensity headache mimicking symptoms of a ruptured cerebral aneurysm. | Hui Liu Yong Wang Jian-Xiong An John P Williams Doris K Cope | 2016 | Chinese Medical Journal2016，，4： | 7 |
| 3 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 4 | Three Cases of Idiopathic Superior Laryngeal Neuralgia Treated by Superior Laryngeal Nerve Block under Ultrasound Guidance显示文摘In treating superior laryngeal neuralgia (SLN),superior laryngeal nerve blocks (SLNBs) can provide immediate relief of persistent pain.Although SLNB was effective,the procedure can increase the risks due to the proximity to the carotid artery,external vein,and other vessels.To avoid complications such as advertent intravascular injection,local anesthetic toxicity from intravascular absorption,and intratracheal injection,we successfully blocked the superior laryngeal nerve under ultrasound guidance in three patients suffering from SLN.The written informed consent before treatment was obtained for each patient participating in this study. | Jian-Ping Wu Flui Liu Jian-Xiong An Doris K Cope John P Williams | 2016 | Chinese Medical Journal2016，，16： | 3 |
| 5 | Tucker,performance of wdm ring and bus networks in the present of homodyne crosstalk显示文摘 | Jonathan P R Lacey Rodney S | 1999 | Journal of Lightwave Technology1999，17，3： | 1 |
| 6 | Depressive illness显示文摘 | Doris A Ebmeier K Shajahan P | 1999 | Lancet1999，354，9187： | 1 |
| 7 | Role of HIF-1 alpha in hypoxiamediated apoptosis,cell proliferation andtumour angiogenes 显示文摘 | Carmeliet P DorY Herbert JM | 1998 | Nature1998，394，6692： | 1 |
| 8 | Immunohistochemical evaluation of estrogen and progesterone receptors in adenoid cystic carcinoma of salivary gland origin显示文摘 | Dori S Trougouboff P David R | 2000 | Oral Oncol2000，36，5： | 1 |
| 9 | Unprecedented detail,speed and image quality显示文摘 | Alexander Z Doris P | 2004 | Siemens Somatom Session2004，4，14： | 1 |
| 10 | In vitro experimental Zl1 At-anti-CD33 antibody therapy of leukaemia ceils overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin显示文摘 | Thorsten P Zekiye K Doris K | 2010 | Eu- ropean Journal of Nuclear Medicine and Molecu- lar Imaging2010，37，5： | 1 |
| 11 | Maffornation of cortial develop6 J ment in adult patients显示文摘 | Tinuper P Doris G Bisulli F | 2003 | Epileptic Disord2003，2，： | 1 |
| 12 | High-throughput multiplex SNP genotyping with MALDI-TOF mass spectrometry,practice,problem and promise显示文摘 | Bray M S Boerwinkle E Doris P A | 2001 | Hum Mutant2001，17，： | 1 |
| 13 | Genetic diversity and bark physiology of the European beech(Fagus sylvatica ):a co-evolutionary re- lationship with the beech scale 显示文摘 | Doris K Ralf P | 2000 | Tree Physiology2000，20，： | 1 |
| 14 | Cellular apoptosis is associated with increased caveolin-1 expression in macrophages显示文摘 | Gargalovic P Dory L | 2003 | J Lipid Res2003，44，9： | 1 |
| 15 | Cellular apoptosis is associated with increased caveolin-1 expression in macrophages显示文摘 | Gargalovic P Dory L | 2003 | J Lipid Res2003，44，9： | 1 |
| 16 | Ligand accessibility as means to control cell response to bioactive bilayer membranes显示文摘 | Dori Y Havazelet B P Satija S K Fields G B | 2000 | J Biorned Mater Res2000，50，1： | 1 |
| 17 | Applicability of the bioluminescence inhibition test in the 96-well microplate format for PAH-solutions and elutriates of PAH-contaminated soils显示文摘 | Doris Hirmann Andreas P Loibner Rudolf Braun | | Chemosphere0，67，6： | 1 |
| 18 | Vitrifying star-shaped liquid crystals: synthesis and application in cholesteric polymer networks显示文摘 | Doris H Peter S | 2002 | Liq Cryst2002，29，12： | 1 |
| 19 | Hypertension genetics,single nucleotide polymorphisms,and the common disease:common variant hypothesis显示文摘 | Doris P A | 2002 | Hypertension2002，39，22： | 1 |
| 20 | Adjustment of vat milk treatment to optimize whey protein transfer into semi-hard cheese:a case study显示文摘 | CORA C CLAUDIA P DORIS J | | 0，，03： | 1 |
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