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| 1 | Functionally graded additive manufacturing to achieve functionality specifications of osteochondral scaffolds显示文摘 | Mario Monzon Chaozong Liu Sara Ajami Miguel Oliveira Ricardo Donate Viviana Ribeiro Rui L. Reis | 2018 | Bio-Design and Manufacturing2018，1，1： | 6 |
| 2 | The role of sphingosine-1-phosphate in bone remodeling and osteoporosis显示文摘Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation. Sphingosine-1-phosphate(S1 P) is a natural,bioactive sphingolipid that has been shown to play a major role in cardiovascular and immunological pathologies by regulating biological and cellular processes, including migration, differentiation, proliferation and survival. Recent studies also suggest a central role for S1 P in bone diseases, including osteoporosis;however, the effects of S1 P, particularly in bone metabolism, remain to be further elucidated. In this review, we summarize the available literature on the role of S1 P in bone metabolism with a focus on osteoporosis. On the cellular level, S1 P acts as an osteoclast-osteoblast coupling factor to promote osteoblast proliferation and bone formation. Moreover, the recruitment of osteoclast precursors to resorption sites is regulated by the interplay of S1 P gradients and S1 P receptor expression. From a clinical perspective, increasing evidence suggests that systemically elevated S1 P blood levels may serve as an independent risk factor for osteoporosis-related fractures. Taken together, S1 P signaling is a potential therapeutic target and may serve as a novel biomarker in patients with systemic bone disease. | Justus M.Grewe Paul-Richard Knapstein Antonia Donat Shan Jiang Daniel JSmit Weixin Xie Johannes Keller | 2022 | Bone Research2022，10，2： | 5 |
| 3 | Effects of Allogeneic Red Blood Cell Transfusions on Clinical Outcomes in Patients Undergoing Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis显示文摘 | Austin G. Acheson Matthew J. Brookes Donat R. Spahn | 2012 | Annals of Surgery2012，，2： | 3 |
| 4 | Telomeres in cancer and ageing显示文摘 | Luis E. Donate Maria A. Blasco | 2011 | 2011 (1561)2011，，1561： | 2 |
| 5 | A Randomized Controlled Trial on Pharmacological Preconditioning in Liver Surgery Using a Volatile Anesthetic显示文摘 | Beatrice Beck-Schimmer Stefan Breitenstein Severin Urech Elisena De Conno Moritz Wittlinger Milo Puhan Wolfram Jochum Donat R. Spahn Rolf Graf Pierre-Alain Clavien | 2008 | Annals of Surgery2008，，6： | 2 |
| 6 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 7 | Pharmacokinetics of clopidogrel 显示文摘 | Caplain H Donat F Gaud C | 1999 | Semin Thromb Hemost1999，25，2： | 1 |
| 8 | Quality control in transurethral resection ofbladder tumors显示文摘 | Herr HW Donat SM | 2008 | BJU Int2008，102，2： | 1 |
| 9 | Data visualization, data reduction and classifier fusion for intelligent fault diagnosis in gas turbine engines显示文摘 | Donat W Choi K An W | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，4： | 1 |
| 10 | Evaluation of ventricutar synchrony using novel Doppler echocardiographic indices in patients with heart failure receiving cardiac resynchronization therapy 显示文摘 | Sun JP Chinchoy E Donat E | 2004 | J Am Soc Echocardiogr2004，17，8： | 1 |
| 11 | Sepsis and serum cytokine concentrations显示文摘 | Pierre Damas Jean-Luc Canivet Donat De Groote Yvonne Vrindts Adelin Albert Paul Franchimont Maurice Lamy | 1997 | Critical Care Medicine1997，，3： | 1 |
| 12 | Reduced bladder tumour recurrence rate associated with narrow-band imagingsurveillance cystoscopy显示文摘 | Herr HW Donat SM | 2011 | BJU Int2011，107，3： | 1 |
| 13 | Factors associated with bronchiectasis in patients with COPD显示文摘 | Martinez-Garcia MA Soler-Cataluna JJ Donat Sanz Y | 2011 | Chest2011，140，： | 1 |
| 14 | Thermodynamics of Pb2+ and Ni2+ adsorption onto natural bentonite from aqueous solutions 显示文摘 | DONAT R AKDOGAN A ERDEM E | 2005 | Journal of Colloid & Interface Science2005，286，1： | 1 |
| 15 | Optimizing neural net based predictive control显示文摘 | Bhat N McAvoy T J | 1990 | Proc American Control Cont1990，3，： | 1 |
| 16 | Prospective study of contrastsensitivity and visual effects after LASIK显示文摘 | Donate D Denis P Burillon C | 2005 | J Fr Ophthalmol2005，28，10： | 1 |
| 17 | A re-staging transurethrall resec- tion predicts early progression of superficial bladder canc- er显示文摘 | Herr H W Donat S M | 2006 | BJU International2006，97，6： | 1 |
| 18 | Identification and characterization of immune cells in the ejaculate of infertile and fertile men显示文摘 | Donat H Kastner T Weise W | 2002 | Zentralbl Gynakol2002，124，89： | 1 |
| 19 | Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin显示文摘 | KJ Pienta H Naik A Akhtar K Yamazaki TS Replogle J Lehr TL Donat L Tait V Hogan and A Raz | 1995 | J Natl Cancer Inst1995，，87： | 1 |
| 20 | Influence of high-temperature steam on the reactivity of CaO sorbent for CO2 capture显示文摘 | Donat F Florin N H Anthony E J | 2012 | Environmental Science & Technology2012，46，2： | 1 |
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