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61篇 您的检索式：作者名="Dombkowski"

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	题名	作者	年代	出处	被引量
1	The involvement of XPC protein in the cisplatin DNA damaging treatment-mediated cellular response显示文摘Recognition of DNA damage is a critical step for DNA damage-mediated cellular response. XPC is an important DNA damage recognition protein involved in nucleotide excision repair (NER). We have studied the XPC protein in cisplatin DNA damaging treatment-mediated cellular response. Comparison of the microarray data from both normal and XPCdefective human fibroblasts identified 861 XPC-responsive genes in the cisplatin treatment (with minimum fold change≥1.5).The cell cycle and cell proliferation-related genes are the most affected genes by the XPC defect in the treatment. Many other cellular function genes, especially the DNA repair and signal transduction-related genes, were also affected by the XPC defect in the treatment. To validate the microarray data, the transcription levels of some microarray-identified genes were also determined by an RT-PCR based real time PCR assay. The real time PCR results are consistent with the microarray data for most of the tested genes, indicating the reliability of the microarray data. To further validate the microarray data, the cisplatin treatment-mediated caspase-3 activation was also determined. The Western blot hybridization results indicate that the XPC defect greatly attenuates the cisplatin treatment-mediated Caspase-3 activation. We elucidated the role of p53 protein in the XPC protein DNA damage recognition-mediated signaling process. The XPC defect reduces the cisplatin treatment-mediated p53 response. These results suggest that the XPC protein plays an important role in the cisplatin treatment-mediated cellular response. It may also suggest a possible mechanism of cancer cell drug resistance.	Alan DOMBKOWSKI Lynn CHUANG	2004	Cell Research2004，14，4：	7
2	Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout显示文摘	Dombkowski RA Russell MJ Olson KR		0，，04：	1
3	Guidelines for incorporating non-perfectly matched oligonucleotides into target-specific hybridization probes for a DNA microarray显示文摘	Lee Inhan Dombkowski Alan A Athey Brian D	2004	Nucleic Acids Res2004，32，2：	1
4	Hydrogen sulfide( H2 S) and hypoxia inhib- it salmonid gastrointestinal motility: evidence for H2S as an oxygen sensor显示文摘	DOMBKOWSKI R A NAYLOR M G SHOEMAK- ER E	2011	J Exp Biol2011，214，：	1
5	Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout显示文摘	Dombkowski RA Russell MJ Olson KR	2004	American Journal of physiology2004，286，4：	1
6	Ex vivo targeting of p21 Cipl/Wafl permits relative expansion of human hematopoietic stem cells 显示文摘	Dombkowski DM Zhang JL Scadden DT	2003	Blood2003，102，4：	1
7	Humanovarian cancer stem/progenitor cells are stimulated bydoxorubicin but inhibited by Mullerian inhibiting substance显示文摘	Meirelles K Benedict LA Dombkowski D	2012	Proc Natl Acad Sci USA2012，109，7：	1
8	Off-Label Utilization of Antihypertensive Medications in Children显示文摘	Esther Y. Yoon Kevin J. Dombkowski Albert Rocchini Jen-Jar Lin Matthew M. Davis	2007	Ambulatory Pediatrics2007，，4：	1
9	Stem cell repopulation efficiency but not pool size is governed by p27kip1显示文摘	Cheng T Rodrigues N Dombkowski D	2000	Nat Med2000，6，11：	1
10	Global expression analysis of gene regulatory pathways during endocrine pancreatic development显示文摘	Gu G Wells JM Dombkowski D	2004	Development2004，131，1：	1
11	Effects of phenyle- thyl isothioeyanate on early molecular events in N-nitrosomethyl- benzylamine-induced eytotoxieity in rat esophagus显示文摘	Reen RK Dombkowski AA Kresty LA	2007	Cancer Res2007，67，13：	1
12	Notch 1 activation incre- ases hematopoietic stem cell self-renewal in vivo and favors ly- mphoid over myeloid lineage outcome显示文摘	Stier S Cheng T Dombkowski D et ol	2002	Blood2002，99，7：	1
13	The role of the proto-oneogene Ets2 in acute megakaryocytic leukemia biolo- gy and therapy显示文摘	Ge Y LaFiura KM Dombkowski AA et a!	2008	Leukemia2008，22，52：	1
14	Global expression analysis of gene regulatory pathways during endocrine pancreatic development显示文摘	Gu GQ Wells JM Dombkowski D	2004	Development2004，131，：	1
15	Notchl activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome显示文摘	Stier S Cheng T Dombkowski D	2002	Blood2002，99，7：	1
16	Lineage-negative side population cells with restricted hematopoietic capacity circulate in normal human adult blood:Immunophenotypic and functional characterization显示文摘	Preffer FI Dombkowski D Sykes M	2002	Stem Cells2002，20，5：	1
17	Lineage - negative side -population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization显示文摘	Preffer FI Dombkowski D Sykes M	2002	Stem Cells2002，20，5：	1
18	The need for surveillance of delay in age-appropriate immunization显示文摘	Dombkowski KJ Lantz PM Freed GL	2002	America Journal of Preventive Medicine2002，23，：	1
19	Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytie leukemia显示文摘	Caldwell JT Edwards H Dombkowski AA	2013	PLoS One2013，8，68：	1
20	Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics 显示文摘	Wei X Dombkowski D Meirelles K	2010	Proc Natl Aead Sci U S A2010，107，18：	1

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