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| 1 | 雷公藤免疫调节的体外研究显示文摘目的证实雷公藤能否选择性地抑制LPS、PHA诱导的TNFα、IFNγ的产生,以及它抑制TNFα的免疫学机理。方法采用健康供血者外周血单个核细胞(PBMC)的体外培养及ELISA,测量雷公藤甲素抑制由LPS、PHA诱导的TNFα、IFNγ的能力;通过对PBMC和单核细胞(monocyte)的预处理试验,以及其后的流式细胞仪分析,研究雷公藤抑制TNFα的免疫学机理。结果雷公藤对TNFα、IFNγ的抑制具有剂量依赖性,对TNFα的IC50为5~10ngml,对IFNγ的IC50为0.1~1.0ngml。PBMC和monocytes试验中,雷公藤的不同预处理后的TNFα浓度,与流式细胞分析产生效应的CD14+TNFα+细胞数一致。结论两种预处理方法提示了不同的临床意义。免疫表现型的分析揭示,雷公藤可能与LPS竞争结合CD14受体。该研究为雷公藤可作为抗炎剂治疗麻风反应提供了基本依据。 | 翁小满 Atkinson S Gorak-Stolinska P Dockrell H.M | 2004 | 中华微生物学和免疫学杂志2004，24，12： | 4 |
| 2 | Mycophenolate mofetil increases cytomegalovirus invasive organ disease in renal transplant patients显示文摘 | Sarmiento JM Dockrell DH Schwab TR | | 0，，02： | 1 |
| 3 | Human herpesvirus 6 seronegativity before transplantation predicts the occurrence of fungal infection in liver transplant recipients显示文摘 | Dockrell DH Mendez JC Jones M | 1999 | Transplantation1999，67，3： | 1 |
| 4 | The effect of noiseon children at school: a review显示文摘 | Bridget M Shield Julie E Dockrell | 2003 | Building Acoustics2003，10，2： | 1 |
| 5 | Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease显示文摘 | Parker LC Dockrell DH | 2007 | Am J Respir Crit Care Med2007，175，4： | 1 |
| 6 | Dynamics of cytokine generation in patients with active pulmonary tuberculosis显示文摘 | JO E K PARK J K DOCKRELL H M | 2003 | Curr Opin Infect Dis2003，16，3： | 1 |
| 7 | Targeting t he net2works t hat underpin contiguous immunity in asthma and chro- nic obst ructive pulmonary disease 显示文摘 | Sabroe I Parker LC Dockrell DH | 2007 | Am J Respir Crit Care Med2007，175，4： | 1 |
| 8 | Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility,CD4^+ T cell count,and HIV plasma viral copy number显示文摘 | Dockrell DH Badley AD Algeciras-Schimnich A | 1999 | AIDS Res Hum Retroviruses1999，15，17： | 1 |
| 9 | B -Cell epitopes and quantification of the ESAT - 6 protein of Mycobacterium tuberculosis 显示文摘 | Harboe M Malin AS Dockrell H | 1998 | Infect Immun1998，66，2： | 1 |
| 10 | External and internal noise surveys of London primary schools显示文摘 | Bridget Shield and Julie E Dockrell | 2004 | J Acoust Soc Am2004，115，2： | 1 |
| 11 | Conective tissuegrowth factor (CTGF, CCN2) a marker, mediator and ther- apeutic target for renal fibrosis 显示文摘 | Phanish MK Winn SK Dockrell MK | 2010 | Nephron Exp Nephrol2010，114，3： | 1 |
| 12 | Beyond naming patterns in children with word finding difficulties-Definitions for nouns and verbs显示文摘 | Dockrell J Messer D George R Ralli A | | 0，，16： | 1 |
| 13 | Virulence factors in pneumococcal respiratory pathogenesis 显示文摘 | Preston JA Dockrell DH | 2008 | Future Microbiol2008，3，2： | 1 |
| 14 | A survey of acoustic conditions and noise levels in secondary school classrooms in England 显示文摘 | Bridget Shield RobertConetta Julie Dockrel | 2015 | J Acoust Soc Am2015，137，1： | 1 |
| 15 | Pneumolysin: a double- edged sword during the host-pathogen interaction 显示文摘 | Marriott HM Mitchell TJ Dockrell DH | 2008 | Curt Mol Med2008，8，6： | 1 |
| 16 | B-cell epitopes and quantification of the ESAT-6 protein of mycobacterium tuberculosis显示文摘 | Harboe M Malin AS Dockrell HS | 1998 | Infect Immun1998，66，： | 1 |
| 17 | Do alltrees carry the seeds of their own destruction? PCR reveals nu- merans wood decay fungi latently present in sapwood of a wide range of angiosperm trees显示文摘 | Parfitt D Hunt J Dockrell D Rogers H J Boddy L | 2010 | Fungal Ecology2010，3，： | 1 |
| 18 | Evolving controversies and challenges in the management of opportunistic infections in HIV-seropositive individuals显示文摘 | Dockrell DH Edwards S Fisher M | 2011 | Journal of Infection2011，63，3： | 1 |
| 19 | B-cell epitopes and quantification of the ESAT 6 protein of Mycobacterium tuberculosis 显示文摘 | Harboe M Malin AS Dockrell HS | 1998 | Infect Immun1998，66，2： | 1 |
| 20 | An investigation of the reliability of Rapid Upper Limb Assessment ( RULA ) as a method of assessment of children's computing posture 显示文摘 | Dockrell S O'Grady E Bennett K | 2012 | Appl Ergon2012，43，3： | 1 |
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