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| 1 | Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats显示文摘AIM: Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis. The aim of the study was to evaluate changes in rnicroperfusion of the pancreas, liver, kidney, stomach,colon, skeletal muscle, and to investigate the influence of heparin on the organ rnicrocirculation in caerulein-induced experimental acute pancreatitis.METHODS: Acute pancreatitis was induced by 4 intraperitoneal injections of caerulein (Cn) (15 μg/kg). The organ microcirculation was measured by laser Doppler flowrnetry. Serum interleukin 6 and hernatocrit levels were analysed.RESULTS: Acute pancreatitis resulted in a significant drop of microperfusion in all examined organs. Heparin administration (2×2.5 mg/kg) improved the rnicrocirculation in pancreas (36.9±4% vs75.9±10%), liver (56.6±6% vs 75.2±16%), kidney (45.1±6% vs79.3±5%), stomach (65.2±8% vs78.1±19%), colon (69.8±6% vs 102.5±19%),and skeletal muscle (59.2±6% vs 77.9±13%). Heparin treatment lowered IL-6 (359.0±66 U/mL vs 288.5±58 U/mL) and hematocrit level (53±4% vs 46±3%).CONCLUSION: Hepadn administration has a positive influence on organ microcirculatory disturbances accompanying experimental Cn-induced acute pancreatitis. | Marek Dobosz Lucjanna Mionskowska Stanislaw Ha■ Sebastian Dobrowolski Dariusz Dymecki Zdzislaw Wajda | 2004 | World Journal of Gastroenterology2004，10，17： | 34 |
| 2 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 3 | The Influence of Silver Additives on Titania Photoactivity in the Photooxidation of Phenol显示文摘 | Dobosz A Sobczynski A | 2003 | Water Res2003，37，： | 1 |
| 4 | CMM tough trigger probes testing using a reference axis显示文摘 | DOBOSZ M WOZNIAK A | 2005 | Precision Engineering2005，29，3： | 1 |
| 5 | Increased forensic efficiency of a STR-based Y specific haplotype by addition of the highly polymorphic DYS385 locus显示文摘 | Caglia A Dobosz M Boschi I | 1998 | Int J Legal Med1998，111，3： | 1 |
| 6 | Organ microcirculatory disturbances in experimental acute pancreatitis: A role of nitric oxide 显示文摘 | Dobosz M Hac S Mionskowska L | 2005 | Physiol Res2005，54，4： | 1 |
| 7 | Water detoxifieation: photocatalytic decomposition of phenol on Au/TiO2 显示文摘 | DOBOSZ A SOBCZYNSKI A | 2001 | Monatsh Chem2001，132，： | 1 |
| 8 | Prophylactic sllbmu cosal saline-adrenaline injection in colonoscopic polypectomy: pro- spective randomized study显示文摘 | Dobrowolski S Dobosz M Babicki A | 2004 | Surg gndosc2004，18，6： | 1 |
| 9 | Absolute keV photon yields from ultrashort laser field induced hot nanoplasmas显示文摘 | Dobosz S Lezius M Schmidt M | 1997 | Phys Rev1997，56，4： | 1 |
| 10 | A repository of 14 PCR-loci Italian gene frequencies in the world wide web显示文摘 | MAVIGLIA R DOBOSZ M BOSCHI I | 2001 | Forensic Sci Int2001，115，： | 1 |
| 11 | High-resolution laser linear encoder with numerical error compensation显示文摘 | Marek DOBOSZ | 1999 | Optic Engineering1999，38，6： | 1 |
| 12 | Presence of homozygous KITexon 11 mutations is strongly associated with malignant clinical be-havior in gastrointestinal stromal tumors 显示文摘 | LasotaJ vel Dobosz Wasag B | 2007 | Lab Invest2007，87，10： | 1 |
| 13 | Investigation of nicotine transformation products by densitometric TLC and ACTA显示文摘 | Tyrpien K C Dobosz A Chr □□ciewicz | 2003 | Chromatographica2003，13，： | 1 |
| 14 | The Influence of Silver Additives on Titania Photoactivity in the Photooxidation of Phenol显示文摘 | Dobosz A Sobczynski A | 2003 | Water Research2003，，37： | 1 |
| 15 | EPR spectroscopy and imaging of TEMPO-labeled magnetite nanoparticles显示文摘 | Krzyminiewski R Kubiak T Dobosz B | 2014 | Current Applied Physics2014，14，5： | 1 |
| 16 | Fat level in body of juvenile Atlantic salmon,and sea trout,and method of estimation from morphometric data显示文摘 | Deboski P Dobosz S Robak S | 1999 | Archives of Polish Fisheries1999，7，： | 1 |
| 17 | Lichtenstein inguinal hemioplasty using butyl-2-cyanoacrylate versus sutures,preliminary experience of a prospective randomized trial显示文摘 | ObilskiW Dobosz M Wojciechowicz T | | 0，，： | 1 |
| 18 | Photocatalysis by illuminated titania:oxidation of hydroquinone and P-benzoquinone显示文摘 | SOBCZYNSKI A DUCZMAL L DOBOSZ A | 1999 | Monatshefte Chemie1999，130，3： | 1 |
| 19 | Androgenesis in rainbow trout using cryopreserved spermatozoa:the effect of processing and biological factors显示文摘 | BABIAK I DOBOSZ S GORYCZKO K | 2002 | Theriogenology2002，57，： | 1 |
| 20 | The Influence of Silver Additives on Titania Photoactivity in the Photooxidation of Phenol显示文摘 | Dobosz A Sobczynski A | 2003 | War Res2003，，37： | 1 |
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