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| 1 | Mechanism of Action of Natural Products Used in the Treatment of Diabetes Mellitus显示文摘糖尿病 mellitus (DM ) 是不够或低效的胰岛素秘书反应引起的新陈代谢的混乱,它被增加的血葡萄糖层次(多糖症) 描绘。DM 是症候群的一个 heterogonous 组。葡萄糖是为身体的主要精力来源,并且在 DM 的情况中,葡萄糖的管理变得不规则。在在 DM,也就是增加的肝的葡萄糖生产,减少的胰岛素分泌物,和损害胰岛素行动的多糖症的发作有三个关键缺点。常规药由改进胰岛素敏感治疗糖尿病,增加胰岛素生产或减少在血的葡萄糖的数量。这篇文章提供很流行的血糖过低的植物的行动的模式的全面评论,例如人参,痛苦的甜瓜,胡芒巴, banaba, Gymnema sylvestre 和黄连属 chinensis。植物由增加胰岛素分泌物行动,提高由脂肪质、骨胳的肌肉纸巾的葡萄糖举起,禁止肠的葡萄糖吸收并且禁止肝的葡萄糖生产。尽管从动物和人的证据一致地支持这些 phytomedicines 的治疗学的效果, multicenter 当同时管理了时,大规模临床的审判没被进行评估有常规药的这些草药的药和他们的相互作用的安全和功效。 | Pranav Kumar Prabhakar Mukesh Doble | 2011 | Chinese Journal of Integrative Medicine2011，17，8： | 16 |
| 2 | Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures显示文摘我们试图在有一般麻药 transperineal (TP ) 的男人决定短期的报导病人的结果前列腺活体检视。未来的队研究在有诊断 TP 活体检视的男人被执行。这用立即活体检视以后的一张验证并且适应的问询表并且在后续被做在越过三个第三级的工作分派的 7 和 14 天之间,有回答的医院 51.6% 评价。立即,在活体检视以后,人的 43/201 (21.4%) 感觉到头昏眼花, syncopal,或承受中略。百分之 53 个人在活体检视以后感到了不快(与 95% 得分 < 5 在 0-10 规模) 。12 在过程以后立即从 196 个人(6.1%) 感到了疼痛。尽管有症状的高发生(例如直到 75% 有的一些血尿症, 47% 得了一些疼痛) ,它不是为大多数的一个中等或严重的问题,除了 31 个人承受了的 hemoejaculate。十一个人需要 catheterization (5.5%) 。由于复杂并发症没有住院病人录取(血尿症,败血) 。在重复在一个以后的时间点询问以后,仅仅人的 25/199 (12.6%) 说尽管有重要、显著的减小,重复活体检视将是一个重要问题。从这研究,我们断定那 TP 活体检视很好与类似的副作用侧面和人的态度被容忍重复活体检视到有 TRUS 活体检视的人。这些数据给予与局部麻醉 TP 活体检视为 tolerability 在 TP 活体检视和一个基准以前人建议通知为临床的使用正在被开发。 | Karan Wadhwa Lina Carmona-Echeveria Timur Kuru Gabriele Gaziev Eva Serrao Deepak Parasha Julia Frey Ivailo Dimov Jonas Seidenader Pete Acher Gordon Muir Andrew Doble Vincent Gnanapragasam Boris Hadaschik Christof Kastner | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 3 | Synergism between natural products and antibiotics against infectious diseases显示文摘 | Shanmugam Hemaiswarya Anil Kumar Kruthiventi Mukesh Doble | 2008 | Phytomedicine2008，，8： | 3 |
| 4 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 5 | Optimisation of HPLC gradient separations using artificial neural networks (ANNs): Application to benzodiazepines in post-mortem samples显示文摘 | Rebecca Webb Philip Doble Michael Dawson | 2009 | Journal of Chromatography B2009，，7： | 1 |
| 6 | The applications of MEMS technology for adaptive optics in vision science 显示文摘 | Doble N Williams D | 2004 | IEEE Quantum Electronics2004，10，3： | 1 |
| 7 | 显示文摘 | Doble BW | 1995 | Mol Cell Biochem1995，143，1： | 1 |
| 8 | Transcatheter aortic valve implantation(TAVI)for treatment of aortic valve stenosis:an evidence-based Analysis(part B)显示文摘 | Sehatzadeh S Doble B Xie F | | 0，，： | 1 |
| 9 | GSK-3: tricks of the trade for a multi-tasking kinase显示文摘 | Doble BW Woodgett JR | 2003 | J Cell Sci2003，116，7： | 1 |
| 10 | Glycogen synthase ki- nase 3alpha-specific regulation of murine hepatic glycogen metabolism 显示文摘 | MacAulay K Doble BW Patel S | 2007 | Cell Metab2007，106，9： | 1 |
| 11 | Synthesis,antimyeobaeterial activity evaluation, and QSAR studies of chalcone derivatives 显示文摘 | P M Sivakumar S Prabu Seenivasan Vanaja Kumar Mukesh Doble | 2007 | Bioorganic & Medicinal Chemistry Letters2007，17，6： | 1 |
| 12 | Synergism between natural products and antibiotics against infectious diseases显示文摘 | Hemaiswarya S Kruthiventi A K Doble M | 2008 | Phytomedicine2008，15，： | 1 |
| 13 | GSK-3: tricks of the trade for a multi-tasking kinase显示文摘 | DOBLE B W WOODGETT J R | 2003 | J Cel Sei2003，116，7： | 1 |
| 14 | Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrone(CPPS)显示文摘 | Batstone GR Doble A Gaston JS | 2002 | Clinical and Experimental Immunology2002，128，2： | 1 |
| 15 | Auto immune T cell responses to semin&l pl&sm& in chronic pelvic p&in syndrome (CPPS)显示文摘 | Batst one GE Doble A Gaston JS | 2002 | Olin Exp Immunol2002，128，2： | 1 |
| 16 | GSK3: tricks of the trade for a multi-tasking kinase显示文摘 | Doble B W Woodgett J R | 2003 | J Cell Sci2003，116，7： | 1 |
| 17 | Physicochemical characterisation and biological evaluation of polyvinylpyrrolidone-iodine engineered polyurethane显示文摘 | Khandwekar AP Doble M | 2011 | J Mater Sci2011，22，5： | 1 |
| 18 | A pattern for reuse: let architectural reuse guide component reuse显示文摘 | JOHN D McGregor JIM Doble ASHA Keddy | 1996 | Object Magazine1996，6，2： | 1 |
| 19 | The role of excitotoxicity in neurodegenerative dis ease: implications for therapy 显示文摘 | Doble A | 1999 | Pharmacol Ther1999，81，： | 1 |
| 20 | al,Use of a micro-electro mechanical mirror for adaptive optics in the human eye 显示文摘 | Doble N Yoon G Y Chen L et | 2002 | Opt Lett2002，27，17： | 1 |
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