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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Mimicking unfolding motion of a beetle hind wing显示文摘This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings. | MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung GOO Nam S | 2009 | Chinese Science Bulletin2009，54，14： | 3 |
| 3 | Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance显示文摘 | Kim Dae Hwan Shin Nari Kim Gwang Ha Song Geum Am Jeon Tae-Yong Kim Dong-Heon Lauwers Gregory Y Park Do Youn | 2013 | Archives of Pathology & Laboratory Medicine2013，，8： | 2 |
| 4 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 5 | Directional multiscale mod- eling of images using the contourlet transform显示文摘 | PO D D Y DO M N | 2006 | IEEE Transactions on Image Processing2006，15，6： | 1 |
| 6 | Isolation and characterization of a cDNA encoding chalcone synthase homolog from Phalaenopsis显示文摘 | Hsu W S Do Y Y Huang P L | 1997 | Plant Physiol1997，113，： | 1 |
| 7 | Distribution of antibody ti-ters to mycoplasma pneumoniae in korean children in2000-2003显示文摘 | Yu J Yoo Y Kim do K | 2005 | J Korean Med Sci2005，20，4： | 1 |
| 8 | Multiple primary cancers in patients with non-Uodgkin's lymphoma显示文摘 | Song H Do Y Lee W | 2006 | J Clin Oncol2006，，17： | 1 |
| 9 | The BIS and hemodynamic changes in major burn patients according to a slow infusion of propofol for induction显示文摘 | Bae JY Choi do Y Woo CH | 2011 | Korean J Anesthesiol2011，60，： | 1 |
| 10 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 11 | Comparison of the efficacy of tenofovir and entecavir for the treatment of nucleos (t)ide-naive patients with chronic hepatitis B 显示文摘 | Do an UB Kara B Gtimtirdtilti Y | 2012 | Turk J Gastroenterol2012，23，3： | 1 |
| 12 | Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats显示文摘 | Kim do Y Chung SI Ro SW | 2013 | Apoptosis2013，18，12： | 1 |
| 13 | Fuzzy system reliability analysis by the use of Tw (the weakest t-norm) on fuzzy number arithmetric operation显示文摘 | Do H Y | 1997 | Fuzzy sets and systems1997，90，： | 1 |
| 14 | The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells(hMSCs)and in-duce chondrogenesis显示文摘 | Kim J H Park J S Yang H N Woo D G Jeon S Y Do H J | 2011 | Biomaterials2011，32，： | 1 |
| 15 | Bryostatin-1 in combination with ealeium ionophore promotes the maturation of human umbilical cord-blood monocyte-derived dendritic cells capable of activating neonatal alloreactive T eells显示文摘 | Do Y Mainali E Nagarkatti PS | 2004 | Cell Immunol2004，231，12： | 1 |
| 16 | ERK1/2 activation attenuates TRAIL-induced apoptosis through the regulation of mitochondria-dependent pathway显示文摘 | Lee do y Lee MW Lee HJ | 2006 | Toxicol In Vitro2006，20，6： | 1 |
| 17 | A biomechanical comparison of modem anterior and posterior plate fixation of the cervical spine 显示文摘 | Do Koh Y Lim TH Won You J | 2001 | Spine2001，26，1： | 1 |
| 18 | Genomic organization of a diverse ACC synthase gene family in banana and expression characteristics of the gene member involved in ripening of banana fruits显示文摘 | Huang F C Do Y Y Huang P L | 2006 | Journal of Agricultural and Food Chemistry2006，54，11： | 1 |
| 19 | Angoitensin Ⅱ has multiple profibrotic effects in human cardiac fibroblasts显示文摘 | Kawano H Do YS Kawano Y | | 0，，10： | 1 |
| 20 | Induction of pluripotent stem cells from mouse embryonic fi brohlasts by (1ct4 and Klf4 with smalb molecule compounds显示文摘 | Shi Y Desponts C Do JT | 2008 | Cell Stem Ce112008，3，5： | 1 |
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