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| 1 | Role of the Ilizarov non-free bone plasty in the management of long bone defects and nonunion: Problems solved and unsolved显示文摘BACKGROUND Ilizarov non-free bone plasty is a method of distraction osteogenesis using the Ilizarov apparatus for external fixation which originated in Russia and was disseminated across the world. It has been used in long bone defect and nonunion management along with free vascularized grafting and induced membrane technique. However, the shortcomings and problems of these methods still remain the issues which restrict their overall use.AIM To study the recent available literature on the role of Ilizarov non-free bone plasty in long bone defect and nonunion management, its problems and the solutions to these problems in order to achieve better treatment outcomes.METHODS Three databases(Pub Med, Scopus, and Web of Science) were searched for literature sources on distraction osteogenesis, free vascularized grafting and induced membrane technique used in long bone defect and nonunion treatment within a five-year period(2015-2019). Full-text clinical articles in the English language were selected for analysis only if they contained treatment results,complications and described large patient samples(not less than ten cases for congenital, post-tumor resection cases or rare conditions, and more than 20 cases for the rest). Case reports were excluded.RESULTS Fifty full-text articles and reviews on distraction osteogenesis were chosen.Thirty-five clinical studies containing large series of patients treated with this method and problems with its outcome were analyzed. It was found that distraction osteogenesis techniques provide treatment for segmental bone defects and nonunion of the lower extremity in many clinical situations, especially in complex problems. The Ilizarov techniques treat the triad of problems simultaneously(bone loss, soft-tissue loss and infection). Management of tibial defects mostly utilizes the Ilizarov circular fixator. Monolateral fixators are preferable in the femur. The use of a ring fixator is recommended in patients with an infected tibial bone gap of more than 6 cm. High rates of successful treatment were reported by the authors that ranged from 77% to 100% and depended on the pathology and the type of Ilizarov technique used. Hybrid fixation and autogenous grafting are the most applicable solutions to avoid after-frame regenerate fracture or deformity and docking site nonunion.CONCLUSION The role of Ilizarov non-free bone plasty has not lost its significance in the treatment of segmental bone defects despite the shortcomings and treatment problems encountered. | Dmitry Y Borzunov Sergei N Kolchin Tatiana A Malkova | 2020 | World Journal of Orthopedics2020，11，6： | 13 |
| 2 | Ilizarov bone transport combined with the Masquelet technique for bone defects of various etiologies (preliminary results)显示文摘BACKGROUND The Ilizarov bone transport(IBT)and the Masquelet induced membrane technique(IMT)have specific merits and shortcomings,but numerous studies have shown their efficacy in the management of extensive long-bone defects of various etiologies,including congenital deficiencies.Combining their strong benefits seems a promising strategy to enhance bone regeneration and reduce the risk of refractures in the management of post-traumatic and congenital defects and nonunion that failed to respond to other treatments.AIM To combine IBT and IMT for the management of severe tibial defects and pseudarthrosis,and present preliminary results of this technological solution.METHODS Seven adults with post-traumatic tibial defects(subgroup A)and nine children(subgroup B)with congenital pseudarthrosis of the tibia(CPT)were treated with the combination of IMT and IBT after the failure of previous treatments.The mean number of previous surgeries was 2.0±0.2 in subgroup A and 3.3±0.7 in subgroup B.Step 1 included Ilizarov frame placement and spacer introduction into the defect to generate the induced membrane which remained in the interfragmental gap after spacer removal.Step 2 was an osteotomy and bone transport of the fragment through the tunnel in the induced membrane,its compression and docking for consolidation without grafting.The outcomes were retrospectively studied after a mean follow-up of 20.8±2.7 mo in subgroup A and 25.3±2.3 mo in subgroup B.RESULTS The“true defect”after resection was 13.3±1.7%in subgroup A and 31.0±3.0%in subgroup B relative to the contralateral limb.Upon completion of treatment,defects were filled by 75.4±10.6%and 34.6±4.2%,respectively.Total duration of external fixation was 397±9.2 and 270.1±16.3 d,including spacer retention time of 42.4±4.5 and 55.8±6.6 d,in subgroups A and B,respectively.Bone infection was not observed.Postoperative complications were several cases of pin-tract infection and regenerate deformity in both subgroups.Ischemic regeneration was observed in two cases of subgroup B.Complications were corrected during the course of treatment.Bone union was achieved in all patients of subgroup A and in seven patients of subgroup B.One non-united CPT case was further treated with the Ilizarov compression method only and achieved union.After a follow-up period of two to three years,refractures occurred in four cases of united CPT.CONCLUSION The combination of IMT and IBT provides good outcomes in post-traumatic tibial defects after previous treatment failure but external fixation is longer due to spacer retention.Refractures may occur in severe CPT. | Dmitry Y Borzunov Sergey N Kolchin Denis S Mokhovikov Tatiana A Malkova | 2022 | World Journal of Orthopedics2022，13，3： | 6 |
| 3 | Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression显示文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the'ideal biomarker.'A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. | Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza | 2021 | Journal of Geriatric Cardiology2021，18，1： | 4 |
| 4 | Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants显示文摘 | Svetlana V Garkina Tatiana V Vavilova Dmitry S Lebedev Evgeny N Mikhaylov | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 5 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 6 | Discrimination of ventricular tachycardia and localization of its exit site using surface electrocardiography显示文摘Differential diagnosis of supraventricular tachycardia (SVT) and ventricular tachycardia (VT) is of paramount importance for appropriate patient management. Several diagnostic algorithms for discrimination of VT and SVT based on surface electrocardiogram (ECG) analysis have been proposed. Following established diagnosis of VT,a specific origination tachycardia site can be supposed according to QRS complex characteristics. This review aims to cover comprehensive and comparative description of the main VT diagnostic algorithms and to present ECG characteristics which permit to suggest the most common VT origination sites. | Heber Ivan Condori Leandro Dmitry S Lebedev Evgeny N Mikhaylov | 2019 | Journal of Geriatric Cardiology2019，16，4： | 2 |
| 7 | Percutaneous interventions in elderly patients with atrial fibrillation: leftatrial ablation and left atrial appendage occlusion显示文摘Heart rhythm disturbances become of special importancewhen patients reach a senior age. Atrial fibrillation (AF) isthe most prevalent arrhythmia among the old age groups,and its impact on morbidity and mortality becomes of para-mount significance. In this population, AF is responsible forsignificant amount of thromboembolic cerebrovascularevents, especially for disabling and fatal strokes, Follow-ing announcement of the special issue of the Journal of Geri-atric Cardiology devoted to heart rhythm disorders in theelderly, a number of submissions have been received withAF as the major topic of authors' researches. | Evgeny N Mikhaylov Tamas Szili-Torok Dmitry S Lebedev | 2017 | Journal of Geriatric Cardiology2017，14，9： | 2 |
| 8 | Renal artery denervation suppresses intractable ventricular arrhythmia in patients with left heart thrombosis显示文摘Transcutaneous renal artery denervation (RND) has beeninitially developed for destruction of efferent nerve fireswith luminal delivery of radiofrequency or ultrasonic energyaiming blood pressure reduction in patients with refractoryhypertension. However, other positive results of RNDwere described afterwards, and they include suppression ofatrial fibrillation and ventricular tachycardia (VT) storm. | Marianna A Vander Petr A Fedotov Tamara A Lyubimtseva Maria A Bortsova Maria Yu Simikova Dmitry S Lebedev Evgeny N Mikhaylov | 2017 | Journal of Geriatric Cardiology2017，14，9： | 2 |
| 9 | Application of Magic-Angle Spinning NMR to Examine the Nature of Protons in Titanate Nanotubes显示文摘 | Bavykin Dmitry V Carravetta Marina Kulak Alexander N | 2010 | Chemistry of Materials2010，22，8： | 1 |
| 10 | Critical theory and the pragmatist challenge显示文摘 | Dmitri N Shalin | 1992 | American Journal of Sociology1992，98，9： | 1 |
| 11 | Effect of hemagglutinin glycoprotein on influenza virus susceptibility to neuraminidase inhibitors 显示文摘 | Vasiliy P M Dmitri N Frederick G | 2005 | J Virol2005，79，12： | 1 |
| 12 | Effect of Two-and Three-locus linkage disequilibrium on the power to detect marker/phenotype associations显示文摘 | Dahila M N Margaret G E Dmitri V Z | 2004 | Genetics2004，168，： | 1 |
| 13 | Microsurgical third ventriculostomy with Stenting in intrinsic brain tumors involving anterior third ventricle显示文摘 | David I Alexander N Dmitry N | | 0，，5： | 1 |
| 14 | Chron- ic intermittent hypoxia induces lung growth in adult mice 显示文摘 | Christian Reinke Shannon Bevans-Fonti Dmitry N | 2011 | Am J Physiol Lung Cell Mol Physiol2011，300，2： | 1 |
| 15 | Model validation for the August 10,1996 WSCC system outage显示文摘 | Dmitry N K Carson W T William A M | 1999 | IEEE Transactions on Power Systems1999，14，3： | 1 |
| 16 | The effect of rapid thermal processing (RTP) on TiN coatings deposited by PVD and the steel-turning performance of coated cemen- ted carbide 显示文摘 | Anthoy J Perry J N Steve J Bull Dmitri I P Peter C R Trevor F P Daniel E G James T John J V Robert E D Vladinmir R Alexey B M | 1999 | Surface and Coatings Technology1999，120，121： | 1 |
| 17 | Podocyte-associated molecules in puromycin aminonucleoside nephrosis of the rat 显示文摘 | Pauliina L Niclas S Dmitry N | 2002 | Lab Invest2002，82，： | 1 |
| 18 | SPIE显示文摘 | Napartovich Anatoly P Elkin Nikolay N Vysotsky Dmitry V | 2012 | 8277:1 - 112012，8277，： | 1 |
| 19 | Model validation for August 10, 1996 WSCC system outage显示文摘 | Dmitry N K Carson W T William A M | 1999 | IEEE Trans on Power Systems1999，14，3： | 1 |
| 20 | An interim dynamic induction motor model for stability studies in the WSCC显示文摘 | Pereira L Dmitry N K Mackin P | 2002 | IEEE Trans on Power Systems2002，17，4： | 1 |
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