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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | IGOR L KATHERINE E DMITRIY B | 2001 | The Science of the Total Environment2001，274，3： | 1 |
| 3 | Single-dielectric barrier discharge plasma enhanced aerodynamics:concepts,optimization,and applications显示文摘 | Thomas C C Martiqua L P Dmitriy M O | | 0，，5： | 1 |
| 4 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 5 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 6 | Ruptured aneurysm of the right sinus of valsaiva associated with a ventrieular septal defect and ananomalous coronary artery显示文摘 | Dmitriy N Feldman Christopher L | 2005 | Tex Heart Inst J2005，32，4： | 1 |
| 7 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments显示文摘 | IGOR L KATHERINE E DMITRIY B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 8 | Experimental and theoretical investigation of oxygen glow discharge structure at low pressures显示文摘 | Vlasimir V I Konstantin S K Dmitriy V L | 1999 | IEEE Transaction on Plasma Science1999，27，5： | 1 |
| 9 | Ruptured aneurysm of the right sinus of valsaiva associated with a ventricular septal defect and an anomalous coronary artery显示文摘 | DMITRIY N FELDMAN CHRISTOPHER L | 2005 | Tex Heart Inst J2005，32，4： | 1 |
| 10 | Experimental and theoretical investigation of oxygen glow discharge structure at low pressures 显示文摘 | Vlasimie V I Konstantin S K Dmitriy V L | 1999 | IEEE Transaction on Plasma Science1999，27，5： | 1 |
| 11 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 12 | Single-Dielectric Barrier Discharge Plasma Enhanced Aerodynamics:Con-cepts,Optimization,and Applications显示文摘 | Thomas C Corke Martiqua L Post Dmitriy M Orlov | 2008 | Journal of Propulsion and Power2008，24，5： | 1 |
| 13 | Discrete hedging of American-type options using local risk mini-mization显示文摘 | Coleman T F Dmitriy L Li Y | 2007 | Journal of Banking & Finance2007，31，11： | 1 |
| 14 | Diazene ( HN = NH) is a substrate for nitrogenase: insights into the path- way of N2 reduction 显示文摘 | Brett M B Jammi M C Dmitriy L | 2007 | Biochemistry2007，46，23： | 1 |
| 15 | Characterization of Pasteurella multocida strains isolated from geese显示文摘 | Zsuzsanna Varga Dmitriy V. Volokhov László Stipkovits ákos Thuma Boglárka Sellyei Tibor Magyar | 2013 | Veterinary Microbiology (-)2013，，1： | 1 |
| 16 | Riskbased management of contaminated sediments:Consideration of spatial and temporal patterns in exposure modeling显示文摘 | Igor L Dmitriy B Jerome C | 2002 | Environment Science and Technology2002，36，2： | 1 |
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