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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 3 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | IGOR L KATHERINE E DMITRIY B | 2001 | The Science of the Total Environment2001，274，3： | 1 |
| 4 | Local feature extraction and matching partial objects显示文摘 | DMITRIY B REGLI W C SHOKOUFANDEH A | 2006 | Computer Aided Design2006，38，10： | 1 |
| 5 | Synthesis of fluoro- furazans显示文摘 | Sheremetev Aleksei B Aleksandrova Natal'ya S Dmitriev Dmitrii E | 2006 | Mendeleev Commun2006，16，3： | 1 |
| 6 | Microwave composite dielectrics based on magnesium titanates显示文摘 | ANATOLII B OLEG O DMITRII D | 2007 | Journal of the European Ceramic Society2007，27，8： | 1 |
| 7 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 8 | Graphene-based Composite Materials 显示文摘 | Sasha Stankovich Dmitriy A Dikin Geoffrey H B Dom- mett | 2006 | Nature2006，442，： | 1 |
| 9 | Oxidation of H2S on activated carbon KAU and influence of the surface state显示文摘 | Dmitrii V B Yuri P Z Irina V B | 2007 | Appl Catal B: Environ2007，70，14： | 1 |
| 10 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 11 | Synthesis and Characterization of Conjugated MonoandDithiol Oligomers and Characterization of TheirSelf- Assembled Monolayers 显示文摘 | Bert D B Hong M Dmitrii F | 2003 | Langmuir2003，191，： | 1 |
| 12 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments显示文摘 | IGOR L KATHERINE E DMITRIY B | 2001 | The Science of the Total Environment2001，274，： | 1 |
| 13 | Microwave composite dielectrics based on magnesium titanate, 显示文摘 | ANATOLII B OLEG O DMITRII D | 2007 | J Euro Ceram Soc2007，27，89： | 1 |
| 14 | Impact on molec- ular organization of amylopectin in starch granules upon an- nealing显示文摘 | VaratharajanV Eric B Dmitriy V S | 2013 | Carbohydrate Polymers2013，98，1： | 1 |
| 15 | Hemostasis of massive bleeding from esophageal tumor:A case report显示文摘BACKGROUND Esophageal cancer is a common type of cancer and serious bleeding from esophageal tumors can occur in routine clinical practice.The arrest of bleeding from esophageal tumor is not a trivial task,which can sometimes require non-standard solutions.We report a case of successful hemostasis of massive bleeding from esophageal tumor performed by a novel two-balloon catheter inserted endoscopically,with a local hemostatic treatment applied.CASE SUMMARY A 36-years old male patient with advanced esophageal cancer developed bleeding from the tumor following endoscopic stenting with a self-expanding metal stent.Due to the ineffectiveness of standard approaches,after a medical conference,the patient was treated with a novel method based on the use of a two-balloon catheter creating an isolated area in esophagus and locally dispersing hemostatic polysaccharide powder inside the isolated interior.Hemostasis was successful and subsequent endoscopic examination revealed the presence of organized clot and localized defect,which was coagulated in a planned manner.CONCLUSION The authors present a new catheter-based method of hemostasis of esophageal tumor bleeding. | Aleksei A Kashintsev Dmitriy S Rusanov Mariya V Antipova Sergey V Anisimov Oleg K Granstrem NikolaiYu Kokhanenko Konstantin V Medvedev Eldar B Kutumov Anastasya A Nadeeva Vitali Proutski | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 16 | Synthesis and X-ray studyof novel azofurazan-annulated macrocylic I actams显示文摘 | Aleksei B S Nataliya S A Dmitrii E D | 2005 | J Hetero-cyclic Chem2005，42，4： | 1 |
| 17 | Photoswitchable cyanfluorescent protein for protein tracking 显示文摘 | Dmitriy M C Vladislav V V Dmitry B | 2004 | Nature Biotechnology2004，11，： | 1 |
| 18 | Graphene- based composite materials显示文摘 | Sasha S Dmitriy A D Geoffrey H B D | 2006 | Nature2006，442，： | 1 |
| 19 | Graphene-Based Composite Materials显示文摘 | Stankovich Sasha Dikin Dmitriy A Dommett Geoffrey H B | 2006 | Nature2006，442，： | 1 |
| 20 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments显示文摘 | Igor L Katherine E Dmitriy B | 2001 | The Science of the Total Environment2001，274，： | 1 |
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