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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Liquid crystals derived from hydrogen - bonded supramolecular complexes of pyridinylated hyperbranehed polyglyeerol and cholesterol - based carboxylic Acids 显示文摘 | Theodoros F Leto T Dimitris T | 2005 | Macromolecules2005，38，5： | 1 |
| 3 | A mathematical modelling technique for gaseous and solid fuel reburning in pulverised coalcombustors显示文摘 | Dimitriou D J Kandamby N Lockwood F C | 2003 | Fuel2003，82，15： | 1 |
| 4 | MicroRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival显示文摘 | Rossi S Shimizu M Barbarotto E Nicoloso MS Dimitri F Sampath D | | 0，，： | 1 |
| 5 | The Role of Environmental Factors on Sleep Patterns and School Performance in Adolescents显示文摘 | Dimitriou D Le Comu Knight F Milton P | 2015 | Front Psychol2015，1，6： | 1 |
| 6 | The contribution of scenic beauty indicators in estimating environmental welfare measures: a case study显示文摘 | Ioanna F Dimitris S | 2004 | Social Indicators Research2004，65，： | 1 |
| 7 | Diversity, Activity, and Abundance of Sulfate-Reducing Bacteria in Saline and Hypersaline Soda Lakes显示文摘 | Mirjam F Dimitry Y S Bait L | 2007 | Appl Environ Microbiol2007，73，7： | 1 |
| 8 | A modified runge-kutta-nystr6m method by using phase lag properties for the numerical solution of orbital problems 显示文摘 | Papadopoulos Dimitris F Simos Theodore E | 2013 | Applied Mathematics & Information Seienees(S 1935-0090)2013，7，2： | 1 |
| 9 | Specificity of short interfering RNA determined through gene expression signatures显示文摘 | Dimitri S Leigh F Aparna S | 2003 | Proc Natl Acad Sci USA2003，100，11： | 1 |
| 10 | Why is fresh self- compacting concrete shear thickening? 显示文摘 | Dimitri F Ronny V Schutter G D | 2009 | Cement and Concerete Research2009，39，6： | 1 |
| 11 | Regular linking of cellulose nanocrystals via click chemistry: synthesis and formation of cellulose nanoplatelet gels显示文摘 | Ilari F and Dimitris S A | 2010 | Biomacromolecules2010，11，4： | 1 |
| 12 | Computer simulations and parametric studies of GFRP bridge deck systems显示文摘 | WAN Baolin RIZOS Dimitris C PETROU Michael F | 2005 | Composite Structures2005，69，： | 1 |
| 13 | Traceability data management for food chains 显示文摘 | Dimitris F Ioannis M Basil M | 2006 | British Food Journal2006，108，8： | 1 |
| 14 | Preliminary results显示文摘 | Solivetti FM Dimitri M Color Doppler in the cliagnosis of malignant prostatic neoplasia | 1991 | Arch Ital Urol Nefrol Androl1991，63，2： | 1 |
| 15 | Entrepreneurship, smal and medium size business markets and European economic integration显示文摘 | Samitasa Aristeidis G Kenourgios Dimitris F | | 0，，27： | 1 |
| 16 | Atomic force microscopy of dense and asymmetric cellulose-based membrane显示文摘 | Stamatialis S Dimitris F Dias C R | 1999 | Journal of Membrane Science1999，160，2： | 1 |
| 17 | Entrepreneurship, smal and medium size business markets and European economic integration显示文摘 | Samitasa Aristeidis G Kenourgios Dimitris F | | 0，，27： | 1 |
| 18 | Specificity of short interfeting RNA determined through gene expression signatures显示文摘 | J Dimitri S Leigh F Apama S | 2003 | PNAS2003，5，11： | 1 |
| 19 | Proof load testing for bridge assessment and upgrading显示文摘 | MICHAEL H F DIMITRI V V MARK G S | 2002 | Engineefing Structures2002，22，12： | 1 |
| 20 | Progressive skyline computation in database systems 显示文摘 | Dimitris P Yufei T Greg F | 2005 | ACM Transactions on Database Systems2005，30，1： | 1 |
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