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| 1 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?显示文摘There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neuroprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphorylation of Akt via its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone(8 mg/kg) at 1(intraperitonally), 6, 24, and 48 hours(subcutaneously) post closed-skull traumatic brain injury. The hippocampus was harvested at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a significant decrease in Akt phosphorylation compared to sham operation. However, mice treated with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our findings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury. | Richard Justin Garling Lora Talley Watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu | 2014 | Neural Regeneration Research2014，9，21： | 6 |
| 2 | Erythropoietin protects cere- brocortical neurons from HIV-1 /gpl20-induced damage显示文摘 | Digicaylioglu M Kaul M Fletcher L | 2004 | Neurore- port2004，15，5： | 1 |
| 3 | Erythropoietin - mediated neuroprotection involves cross-talk between Jak2 and NF - kappaB signaling cascades 显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 4 | Erythropoietin-mediated neu- roprotection involves cross-talk between Jak2 and NF-kappaB sig- nalling cascades显示文摘 | DIGICAYLIOGLU M LIPTON SA | 2001 | Nature2001，412，6847： | 1 |
| 5 | Erythropoietin-media ted neuroprotection involves cross-talk between Jak2 and NFkappa B signaling cascades 显示文摘 | DIGICAYLIOGLU M LIPTON S A | 2001 | Nature2001，412，： | 1 |
| 6 | Localization of specific erythropoietin binding sites in defined areas of the mouse brain显示文摘 | Bichet S Marti HH | 1995 | Proc Natl Acad Sci USA1995，92，9： | 1 |
| 7 | Erythropoietin- mediated neuroprotection involves cross- talk between JAK2 and NF - κB signaling cascades显示文摘 | Digicaylioglu M Lipton S | 2001 | Nature2001，412，6847： | 1 |
| 8 | Erythropoietin-mediated neuroprotection involvescross-talk between Jak2 and NF-kappaB signalling cascades显示文摘 | Digicaylioglu M Lipton S A | 2001 | Nature2001，412，6847： | 1 |
| 9 | Erythropoietin-mediated neuroprotection invotves cross-talk between Jak2 and NF-kappaB signalling cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 10 | Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades显示文摘 | Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 11 | Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I显示文摘 | Digicaylioglu M Garden G Timberlake S | | 0，，： | 1 |
| 12 | Erythropoietin-mediated neuroprotection involves cross-talk between Jak-2 and NF-κB signalling cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，9： | 1 |
| 13 | Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 14 | Erythropoietin-mediated neuroproteetion involves cross-talk between Jak2 and NF-KB signaling caseades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，： | 1 |
| 15 | Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-_B signaling cascades显示文摘 | Digicaylioglu M Lipton SA | | 0，，6847： | 1 |
| 16 | Erythopoietin-mediated neuro-protection involves cross-talk between Jak2 and NF-κB signal-ing cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 17 | Localization of specific erythropoietin binding sites in defined areas of the mouse brain显示文摘 | Digicaylioglu M Bichet S Marti HH | 1995 | Proc Natl Acad Sci USA1995，92，9： | 1 |
| 18 | Erythropoietin-mediated neuroprotection involves cross -talk between Jak2 and NFkappaB signaling cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，： | 1 |
| 19 | Erythropoietin mediated neuroprotection involves cross-talk between Jak2 and NFkappaB singling cascades 显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
| 20 | Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades显示文摘 | Digicaylioglu M Lipton SA | 2001 | Nature2001，412，6847： | 1 |
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