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| 1 | Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for persistent/recurrent and metastatic differentiated thyroid cancer 2018 (English version)显示文摘Contents1. Diagnosis and dynamic assessment of persistent/recurrent and metastatic differentiated thyroid cancer (prmDTC)1.1 Basic principles of diagnosis1.2 Diagnostic methods1.3 Ongoing assessment of response to therapy2. Multidisciplinary treatment of prmDTC2.1 Basic principles of treatment2.2 Surgical management2.2.1 Preoperative clinical assessment2.2.2 Principles of surgical treatment for prmDTC. | Yansong Lin Huiqiang Huang Ye Guo Libo Chen | 2019 | Chinese Journal of Cancer Research2019，31，1： | 11 |
| 2 | Generation of pancreatic islet cells from human embryonic stem cells显示文摘Efficiently obtaining functional pancreatic islet cells derived from human embryonic stem(hES) cells not only provides great potential to solve the shortage of islets sources for type I diabetes cell therapy,but also benefits the study of the development of the human pancreas and diabetes pathology.In 2001,hES cells were reported to have the capacity to generate insulin-producing cells by spontaneous differentiation in vitro.Since then,many strategies(such as overexpression of key transcription factors,delivery of key proteins for pancreatic development,co-transplantation of differentiated hES cells along with fetal pancreas,stepwise differentiation by mimicking in vivo pancreatic development) have been employed in order to induce the differentiation of pancreatic islet cells from hES cells.Moreover,patient-specific induced pluripotent stem(iPS) cells can be generated by reprogramming somatic cells.iPS cells have characteristics similar to those of ES cells and offer a new cell source for type I diabetes cell therapy that reduces the risk of immunologic rejection.In this review,we summarize the recent progress made in the differentiation of hES and iPS cells into functional pancreatic islet cells and discuss the challenges for their future study. | ZHANG DongHui1,2,JIANG Wei1,SHI Yan2 & DENG HongKui1,2 1 Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education,College of Life Sciences,Peking University,Beijing 100871,China 2 Laboratory of Chemical Genomics,Shenzhen Graduate School of Peking University,Shenzhen 518055,China | 2009 | Science China(Life Sciences)2009，52，7： | 6 |
| 3 | Current advances in the application of proteomics in apoptosis research显示文摘Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms.Dysregulation of apoptosis has been implicated in a number of diseases,including cancer and autoimmune disease.Thus,the investigation of apoptotic regulation has evoked considerable interest.Many apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic analysis.Recently,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the field.This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future. | WANG LiShun & CHEN GuoQiang Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China E-Institutes of Shanghai Municipal Education Commission Chemical Biology Division,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 4 | Role and pitfalls of hepatic helical multi-phase CT scanning in differential diagnosis of small hemangioma and small hepatocellular carcinoma显示文摘RoleandpitfalsofhepatichelicalmultiphaseCTscanningindiferentialdiagnosisofsmalhemangiomaandsmalhepatocelularcarcinomaYANFuH... | YAN FuHua1, ZENG MengSu1 and ZHOU KangRong1Keywords liver neoplasms/radiography carcinoma, hepatocellular/radiography hemangioma/radiography diagnosis, differential tomography, Xray computed | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 5 | Short exposure to paclitaxel induces multipolar spindle formation and aneuploidy through promotion of acentrosomal pole assembly显示文摘Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity. Live cell imaging showed that some paclitaxel-treated cells accomplished multipolar cell division and a portion of the daughter cells went on to the next round of mitosis. The surviving cells grew into clones with varied genome content. The results indicated that an aneuploidy population could be induced by short exposure to paclitaxel at a low dose, implicating potential side effects of paclitaxel. | BIAN MingLei1, FU JingYan1, YAN Yan1, CHEN Qiang1, YANG Chao2, SHI QingHua2,JIANG Qing1 & ZHANG ChuanMao1 1MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio-membrane and Membrane Bio-engineering, College of Life Sciences, Peking University, Beijing 100871, China 2Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230026, China | 2010 | Science China(Life Sciences)2010，53，11： | 3 |
| 6 | Pancreatic secretory trypsin inhibitor:More than a trypsin inhibitor显示文摘Kazal-type serine protease inhibitor is one of the most important and widely distributed protease inhibitor families.Pancreatic secretory trypsin inhibitor(PSTI),also known as serine protease inhibitor Kazal typeⅠ(SPINK1),binds rapidly to trypsin,inhibits its activity and is likely to protect the pancreas from prematurely activated trypsinogen.Therefore,it is an important factor in the onset of pancreatitis.Recent studies found that PSTI/SPINK1 is also involved in self-regulation of acinar cell phagocytosis,proliferation and growth of a variety of cell lines.In addition,it takes part in the response to inflammatory factor or injury and is highly related to adult type Ⅱ citrullinemia. | Gai-Ping Wang,Cun-Shuan Xu,College of Life Science,Henan Normal University,Xinxiang 453007,Henan Province,China Co-construction Key Laboratory for Cell Differentiation and Regulation,Henan Normal University,Xinxiang 453007,Henan Province,China | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 2 |
| 7 | monns aeruginosa species recovered from cystic fibrosis palienls PCR -based assay for from other Pseudomonas显示文摘 | SPILKER T COENYE T VANDAMME P differentiation of Psertd | 2004 | American Society forMicrobiology2004，42，5： | 1 |
| 8 | Serum lipoprotein (a) level and its clinical significance in patients with systemic lupus erythematosus 显示文摘 | Differential apolipoprotein ( a ) is an independent contributor to Clin Chim Acta Sat4 RA Polat MF Taysi S | 2002 | Clin Rheumatol2002，21，6： | 1 |
| 9 | A clinicopathologie entity for a highrisk group of papillary and follicular carcinomas 显示文摘 | Sakamoto A Kasai N Sugano H Poorly differentiated carcinoma of the thyroid | 1983 | Cancer1983，52，10： | 1 |
| 10 | Revised American Thyroid Associationmanagement guidelines for patients with thyroid nodules and diffe-rentiated thyroid cancer 显示文摘 | American Thyroid Association ( ATA ) Guidelines Taskforce onThyroid Nodules and Differentiated Thyroid Cancer COOPER DS DOHERTY G M | 2009 | Thyroid2009，19，11： | 1 |
| 11 | Revised american thyroid association management guide-lines for patients with thyroid nodules and differentiated thyroid cancer显示文摘 | American Thyroid Association ( ATA) Guidelines Taskforce on Thy-roid Nodules and Differentiated Thyroid Cancer Cooper DS DohertyGM | 2009 | Thyroid2009，19，11： | 1 |
| 12 | Activation-induced cell death vs passive macrophage-dependent deletion 显示文摘 | Gonzalo JA Baixeras E Gonzalez-Garcia A Differential in vivo effects of a superantigen and an antibody targeted to the same T cell receptor | 1994 | J Immunol1994，152，： | 1 |
| 13 | Revised American Thyroid Association managementguidelines for patients with thyroid nodules and differentiated thy-roid cancer显示文摘 | American Thyroid Association Guidelines Taskforce on Thy-roid Nodules and Differentiated Thyroid Cancer Cooper DS Dohe-ity GM | 2009 | Thyroid2009，19，11： | 1 |
| 14 | Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer显示文摘 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer Cooper DS Doherty GM | | 0，，： | 1 |
| 15 | Revised American Thyroid Association management guidelines for patients with thyroid nodules and dif- ferentiated thyroid cancer显示文摘 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer Cooper DS Doherty GM eta1 | 2009 | Thyroid2009，19，11： | 1 |
| 16 | Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer显示文摘 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer Cooper DS Doherty GM | 2009 | Thyroid2009，19，11： | 1 |
| 17 | human adipose tissue stem cells using extracts of rat cardiomyocytes 显示文摘 | Gaustad KG Boquest AC Anderson BE et ah Differentiation of | 2004 | Biochem Biophys Res Commun2004，314，2： | 1 |
| 18 | Human a cardiomyocyt e phenotype in the adult murine heart 显示文摘 | Toma C Pittenger MF Cahill KS mesenchymal stem cells differentiate to | 2002 | Circulation2002，105，1： | 1 |
| 19 | Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer 显示文摘 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer Cooper DS Doherty GM | 2009 | Thyroid2009，19，11： | 1 |
| 20 | Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid Cancer显示文摘 | American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer Cooper D S Doherty G M | 2009 | Thyroid2009，19，11： | 1 |
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